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Also known as
Red Scrotum Syndrome (RSS), Burning Scrotum Syndrome, Male Genital Dysesthesia, Scrotodynia
Definition
Red scrotum syndrome (RSS) is a rare and chronic disease affecting males in their second half of life. It is characterized by erythema with sharp borders, no scaling but burning and pain sensations.1 Despite looking like eczema at first glance, its morphology and course are quite different. The predominant subjective symptoms are burning and hyperalgesia rather than itch. This argues for a possible neurogenic inflammation. RSS resembles erythromelalgia.1
Clinical Context
Red scrotum syndrome (RSS) is a rare disease characterized by persistent redness of the scrotum, often involving the base of the penis, and accompanied by itching, burning, and pain sensations.1 It can develop after prolonged use of topical corticosteroids. The major symptoms are neurological, and RSS resembles erythromelalgia. Treatment options have included oral doxycycline and oral gabapentin. Doxycycline, a tetracycline, has antibiotic and anti-inflammatory effects. Gabapentin is effective in controlling neuropathic pain and itch.1