{"id":32815,"date":"2026-09-04T18:00:00","date_gmt":"2026-09-04T22:00:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32815"},"modified":"2026-09-05T06:00:00","modified_gmt":"2026-09-05T10:00:00","slug":"oxido-nitrico","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/","title":{"rendered":"\u00d3xido N\u00edtrico"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32815","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>\n        O \u00f3xido n\u00edtrico (NO) \u00e9 uma mol\u00e9cula de sinaliza\u00e7\u00e3o gasosa e incolor que funciona como um mediador-chave em in\u00fameros processos fisiol\u00f3gicos, particularmente na ere\u00e7\u00e3o peniana e na vasodilata\u00e7\u00e3o.<sup>1<\/sup> \u00c9 sintetizado endogenamente a partir do amino\u00e1cido L-arginina por v\u00e1rias enzimas \u00f3xido n\u00edtrico sintase (NOS), principalmente a NOS neuronal (nNOS) e a NOS endotelial (eNOS) no tecido peniano.<sup>2<\/sup> O NO atua como o principal neurotransmissor vasoativo n\u00e3o adren\u00e9rgico e n\u00e3o colin\u00e9rgico no p\u00eanis, onde desempenha um papel crucial no in\u00edcio e na manuten\u00e7\u00e3o da ere\u00e7\u00e3o.<sup>3<\/sup>\n    <\/p>\n<p>\n        Ap\u00f3s a estimula\u00e7\u00e3o sexual, o NO \u00e9 liberado tanto pelas termina\u00e7\u00f5es nervosas do nervo cavernoso (via nNOS) quanto pelas c\u00e9lulas endoteliais que revestem os vasos sangu\u00edneos e os sinusoides dos corpos cavernosos (via eNOS).<sup>4<\/sup> Uma vez liberado, o NO se difunde atrav\u00e9s da membrana da c\u00e9lula muscular lisa e ativa a guanilato ciclase sol\u00favel (sGC), que catalisa a convers\u00e3o de trifosfato de guanosina (GTP) em monofosfato de guanosina c\u00edclico (cGMP).<sup>5<\/sup> Esse segundo mensageiro ativa ent\u00e3o a prote\u00edna quinase dependente de cGMP (PKG), que inicia uma cascata de eventos que leva \u00e0 diminui\u00e7\u00e3o dos n\u00edveis de c\u00e1lcio citos\u00f3lico, relaxamento do m\u00fasculo liso cavernoso, aumento do fluxo sangu\u00edneo para o p\u00eanis, compress\u00e3o da drenagem venosa e, finalmente, ere\u00e7\u00e3o peniana.<sup>6<\/sup>\n    <\/p>","gt-synonyms":"Mon\u00f3xido de nitrog\u00eanio, \u00d3xido de nitrog\u00eanio, Mon\u00f3xido de mononitrog\u00eanio, NO, EDRF (Fator de Relaxamento Derivado do Endot\u00e9lio), Radical nitrosila, \u00d3xido N\u00edtrico Derivado do Endot\u00e9lio, Vasodilatador de Nitrato End\u00f3geno, oxoazanil","gt-citation":"[1] Burnett AL. The role of nitric oxide in erectile dysfunction: implications for medical therapy. J Clin Hypertens (Greenwich). 2006;8(12 Suppl 4):53-62. doi: 10.1111\/j.1524-6175.2006.06026.x\n\n[2] Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Pharmacol Ther. 2005;106(2):233-66. doi: 10.1016\/j.pharmthera.2004.11.011\n\n[3] Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev. 2011;63(4):811-59. doi: 10.1124\/pr.111.004515\n\n[4] MacDonald EA, Burnett AL. The role of nitric oxide in erectile function and sexual behavior. J Sex Med. 2021;18(5):872-887. doi: 10.1016\/j.jsxm.2021.02.006\n\n[5] Sullivan ME, Thompson CS, Dashwood MR, et al. Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res. 1999;43(3):658-65. doi: 10.1016\/s0008-6363(99)00135-2\n\n[6] Pereira DA, Silveira TH, Calmasini FB, Silva FH. Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease. Front Pharmacol. 2024;15:1357176. doi: 10.3389\/fphar.2024.1357176","gt-clinical-context":"<p>\n        O \u00f3xido n\u00edtrico desempenha um papel fundamental em v\u00e1rios contextos cl\u00ednicos relacionados \u00e0 fun\u00e7\u00e3o e disfun\u00e7\u00e3o er\u00e9til:\n    <\/p>\n<p>\n        <strong>Disfun\u00e7\u00e3o Er\u00e9til (ED):<\/strong> O comprometimento da bioatividade do NO \u00e9 um importante mecanismo patog\u00eanico subjacente \u00e0 disfun\u00e7\u00e3o er\u00e9til.<sup>1<\/sup> V\u00e1rias condi\u00e7\u00f5es que comprometem a produ\u00e7\u00e3o ou sinaliza\u00e7\u00e3o de NO \u2014 incluindo disfun\u00e7\u00e3o endotelial, diabetes mellitus, hipertens\u00e3o, hipercolesterolemia, envelhecimento e tabagismo \u2014 podem levar \u00e0 ED.<sup>2<\/sup> O reconhecimento do papel central do NO na fun\u00e7\u00e3o er\u00e9til revolucionou o tratamento da ED, levando ao desenvolvimento de inibidores da fosfodiesterase tipo 5 (PDE5), que potencializam os efeitos mediados pelo NO ao impedir a degrada\u00e7\u00e3o do cGMP.<sup>3<\/sup>\n    <\/p>\n<p>\n        <strong>Sa\u00fade Cardiovascular:<\/strong> Al\u00e9m de seu papel na fun\u00e7\u00e3o er\u00e9til, o NO \u00e9 essencial para a sa\u00fade cardiovascular, atuando como um potente vasodilatador que regula a press\u00e3o arterial e o t\u00f4nus vascular.<sup>4<\/sup> A mesma disfun\u00e7\u00e3o endotelial que prejudica a produ\u00e7\u00e3o de NO no tecido peniano frequentemente afeta todo o sistema vascular, o que explica por que a ED \u00e9 frequentemente um marcador precoce de doen\u00e7a vascular sist\u00eamica.<sup>5<\/sup>\n    <\/p>\n<p>\n        <strong>Aplica\u00e7\u00f5es Terap\u00eauticas:<\/strong> A via NO-cGMP \u00e9 o alvo de diversas interven\u00e7\u00f5es terap\u00eauticas para a ED:\n    <\/p>\n<ul>\n<li>Os inibidores da PDE5 (ex.: sildenafila, tadalafila, vardenafila) potencializam os efeitos mediados pelo NO ao inibir a enzima que degrada o cGMP<\/li>\n<li>Estimuladores e ativadores da guanilato ciclase sol\u00favel (sGC) representam terapias emergentes que estimulam diretamente a produ\u00e7\u00e3o de cGMP, potencialmente eficazes quando a biodisponibilidade de NO est\u00e1 reduzida<sup>6<\/sup><\/li>\n<li>A suplementa\u00e7\u00e3o de L-arginina visa aumentar o substrato para a s\u00edntese de NO<\/li>\n<\/ul>\n<p>\n        <strong>Sele\u00e7\u00e3o de Pacientes:<\/strong> A efic\u00e1cia das terapias direcionadas ao NO depende da causa subjacente da ED. Os inibidores da PDE5 s\u00e3o mais eficazes em pacientes com ED leve a moderada e vias neurais intactas. Eles podem ser menos eficazes em casos graves de ED resultantes de dano vascular significativo ou ap\u00f3s prostatectomia radical com les\u00e3o nervosa.<sup>4<\/sup> Tratamentos alternativos, como inje\u00e7\u00f5es intracavernosas, dispositivos de v\u00e1cuo ou pr\u00f3teses penianas, podem ser necess\u00e1rios para pacientes que n\u00e3o respondem aos inibidores da PDE5.<sup>5<\/sup>\n    <\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":true,"gt-view-count":2},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o<\/title>\n<meta name=\"description\" content=\"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o\" \/>\n<meta property=\"og:description\" content=\"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/\" \/>\n<meta property=\"og:site_name\" content=\"Rigicon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/rigiconurology\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-05T10:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rigicon.com\/wp-content\/uploads\/2025\/05\/header-d.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1440\" \/>\n\t<meta property=\"og:image:height\" content=\"718\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o\" \/>\n<meta name=\"twitter:description\" content=\"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.\" \/>\n<meta name=\"twitter:site\" content=\"@rigiconurology\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/oxido-nitrico\\\/\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/oxido-nitrico\\\/\",\"name\":\"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#website\"},\"datePublished\":\"2026-09-04T22:00:00+00:00\",\"dateModified\":\"2026-09-05T10:00:00+00:00\",\"description\":\"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/oxido-nitrico\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/oxido-nitrico\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/oxido-nitrico\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Glossary Terms\",\"item\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/urology-glossary\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"\u00d3xido N\u00edtrico\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#website\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\",\"name\":\"Rigicon\",\"description\":\"Innovative Urological Solutions\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#organization\"},\"alternateName\":\"Innovative Urological Solutions\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#organization\",\"name\":\"Rigicon, Inc.\",\"alternateName\":\"Innovative Urological Solutions\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/cropped-Logo-Square-Kopya.jpg\",\"contentUrl\":\"https:\\\/\\\/www.rigicon.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/cropped-Logo-Square-Kopya.jpg\",\"width\":512,\"height\":512,\"caption\":\"Rigicon, Inc.\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/rigiconurology\\\/\",\"https:\\\/\\\/x.com\\\/rigiconurology\",\"https:\\\/\\\/www.instagram.com\\\/rigiconurology\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@Rigicon\\\/podcasts\",\"https:\\\/\\\/www.youtube.com\\\/Rigicon\",\"https:\\\/\\\/www.threads.net\\\/@rigiconurology\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/rigicon\\\/\"],\"description\":\"Rigicon is a global provider of innovative, diverse, and complete portfolio of prosthetic urology options.\",\"email\":\"operations@rigicon.com\",\"telephone\":\"+1 (888) 202-9790\",\"legalName\":\"Rigicon, Inc.\",\"vatID\":\"81-3545645\",\"taxID\":\"81-3545645\",\"duns\":\"045247683\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o","description":"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/","og_locale":"pt_BR","og_type":"article","og_title":"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o","og_description":"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.","og_url":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/","og_site_name":"Rigicon","article_publisher":"https:\/\/www.facebook.com\/rigiconurology\/","article_modified_time":"2026-09-05T10:00:00+00:00","og_image":[{"width":1440,"height":718,"url":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2025\/05\/header-d.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_title":"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o","twitter_description":"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.","twitter_site":"@rigiconurology","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/","url":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/","name":"\u00d3xido N\u00edtrico: Papel na Ere\u00e7\u00e3o Peniana e Vasodilata\u00e7\u00e3o","isPartOf":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#website"},"datePublished":"2026-09-04T22:00:00+00:00","dateModified":"2026-09-05T10:00:00+00:00","description":"O \u00f3xido n\u00edtrico \u00e9 uma mol\u00e9cula essencial que medeia a ere\u00e7\u00e3o peniana ao relaxar a musculatura lisa e elevar o fluxo sangu\u00edneo cavernoso.","breadcrumb":{"@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/oxido-nitrico\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/www.rigicon.com\/pt-br\/"},{"@type":"ListItem","position":2,"name":"Glossary Terms","item":"https:\/\/www.rigicon.com\/pt-br\/urology-glossary\/"},{"@type":"ListItem","position":3,"name":"\u00d3xido N\u00edtrico"}]},{"@type":"WebSite","@id":"https:\/\/www.rigicon.com\/pt-br\/#website","url":"https:\/\/www.rigicon.com\/pt-br\/","name":"Rigicon","description":"Innovative Urological Solutions","publisher":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#organization"},"alternateName":"Innovative Urological Solutions","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.rigicon.com\/pt-br\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/www.rigicon.com\/pt-br\/#organization","name":"Rigicon, Inc.","alternateName":"Innovative Urological Solutions","url":"https:\/\/www.rigicon.com\/pt-br\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.rigicon.com\/pt-br\/#\/schema\/logo\/image\/","url":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2024\/07\/cropped-Logo-Square-Kopya.jpg","contentUrl":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2024\/07\/cropped-Logo-Square-Kopya.jpg","width":512,"height":512,"caption":"Rigicon, Inc."},"image":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/rigiconurology\/","https:\/\/x.com\/rigiconurology","https:\/\/www.instagram.com\/rigiconurology\/","https:\/\/www.youtube.com\/@Rigicon\/podcasts","https:\/\/www.youtube.com\/Rigicon","https:\/\/www.threads.net\/@rigiconurology","https:\/\/www.linkedin.com\/company\/rigicon\/"],"description":"Rigicon is a global provider of innovative, diverse, and complete portfolio of prosthetic urology options.","email":"operations@rigicon.com","telephone":"+1 (888) 202-9790","legalName":"Rigicon, Inc.","vatID":"81-3545645","taxID":"81-3545645","duns":"045247683"}]}},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-term\/32815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-term"}],"about":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/types\/glossary-term"}],"wp:attachment":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/media?parent=32815"}],"wp:term":[{"taxonomy":"glossary-category","embeddable":true,"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-category?post=32815"},{"taxonomy":"glossary-product","embeddable":true,"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-product?post=32815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}