{"id":32241,"date":"2026-09-02T18:42:00","date_gmt":"2026-09-02T22:42:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32241"},"modified":"2026-09-03T06:12:00","modified_gmt":"2026-09-03T10:12:00","slug":"alprostadil","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/alprostadil\/","title":{"rendered":"Alprostadil"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32241","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"

O alprostadil \u00e9 um an\u00e1logo sint\u00e9tico da prostaglandina E1 (PGE1) utilizado principalmente como tratamento de segunda linha para a disfun\u00e7\u00e3o er\u00e9til em homens quando a terapia oral falhou.1<\/span> Ele atua ligando-se como agonista aos receptores de prostaglandina (por exemplo, EP2), ativando assim a adenilato ciclase. Isso resulta em um ac\u00famulo de monofosfato de adenosina 3’5′-c\u00edclico (cAMP), que \u00e9 respons\u00e1vel pelos efeitos farmacol\u00f3gicos do medicamento, incluindo o relaxamento do m\u00fasculo liso que leva \u00e0 vasodilata\u00e7\u00e3o (aumentando o fluxo sangu\u00edneo perif\u00e9rico e intracavernoso), broncodilata\u00e7\u00e3o e inibi\u00e7\u00e3o da agrega\u00e7\u00e3o plaquet\u00e1ria.1<\/span><\/p>\n","gt-synonyms":"Prostaglandina E1, PGE1, PGE-1, l-Prostaglandina E1, Alprostadilum, Befar, Caverject, Caverject Impulse, Edex, Muse, Vitaros, Femprox, Topiglan, Alprox-TD, Liprostin, Prostandin, Prostin VR Pediatric, Prostavasin, Lipoprost, Promostan, Prostivas, l-PGE1, PGE1alpha, \u00e1cido (11alfa,13E,15S)-11,15-di-hidroxi-9-oxoprost-13-en-1-oico, (-)-Prostaglandina E1","gt-citation":"[1] Jain A, Leslie SW, Iqbal O. Alprostadil. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542217\/\n\n[2] Anaissie J, Hellstrom WJ. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review. Res Rep Urol. 2016;8:123-131. Published 2016 Aug 3. doi:10.2147\/RRU.S68560\n\n[3] Linet OI, Ogrinc FG. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The Alprostadil Study Group. N Engl J Med. 1996;334(14):873-877. doi:10.1056\/NEJM199604043341401\n\n[4] Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med. 1997;336(1):1-7. doi:10.1056\/NEJM199701023360101\n\n[5] Cai T, Palumbo F, Liguori G, et al. The intra-meatal application of alprostadil cream (Vitaros\u00ae) improves drug efficacy and patient's satisfaction: results from a randomized, two-administration route, cross-over clinical trial. Int J Impot Res. 2019;31(2):119-125. doi:10.1038\/s41443-018-0087-6","gt-clinical-context":"

O alprostadil \u00e9 aprovado pelo FDA como tratamento de segunda linha para a disfun\u00e7\u00e3o er\u00e9til quando as terapias orais de primeira linha, como os inibidores da fosfodiesterase tipo 5 (PDE5) (por exemplo, sildenafila), mostram-se ineficazes.1<\/span> Pode ser administrado por meio de inje\u00e7\u00e3o intracavernosa, suposit\u00f3rio intrauretral ou creme t\u00f3pico.2<\/span> O medicamento atua relaxando o tecido muscular liso dos corpos cavernosos, dilatando as art\u00e9rias cavernosas, aumentando o fluxo sangu\u00edneo e levando \u00e0 ere\u00e7\u00e3o.1<\/span><\/p>\n

Para a disfun\u00e7\u00e3o er\u00e9til, o alprostadil est\u00e1 dispon\u00edvel em diversas formula\u00e7\u00f5es:<\/p>\n