{"id":32241,"date":"2026-09-02T18:42:00","date_gmt":"2026-09-02T22:42:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32241"},"modified":"2026-10-06T10:18:12","modified_gmt":"2026-10-06T14:18:12","slug":"alprostadil","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/alprostadil\/","title":{"rendered":"Alprostadil"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32241","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>O alprostadil \u00e9 um an\u00e1logo sint\u00e9tico da prostaglandina E1 (PGE1) utilizado principalmente como tratamento de segunda linha para a disfun\u00e7\u00e3o er\u00e9til em homens quando a terapia oral falhou.<span class=\"citation\">1<\/span> Ele atua ligando-se como agonista aos receptores de prostaglandina (por exemplo, EP2), ativando assim a adenilato ciclase. Isso resulta em um ac\u00famulo de monofosfato de adenosina 3&#8217;5&#8242;-c\u00edclico (cAMP), que \u00e9 respons\u00e1vel pelos efeitos farmacol\u00f3gicos do medicamento, incluindo o relaxamento do m\u00fasculo liso que leva \u00e0 vasodilata\u00e7\u00e3o (aumentando o fluxo sangu\u00edneo perif\u00e9rico e intracavernoso), broncodilata\u00e7\u00e3o e inibi\u00e7\u00e3o da agrega\u00e7\u00e3o plaquet\u00e1ria.<span class=\"citation\">1<\/span><\/p>\n","gt-synonyms":"Prostaglandina E1, PGE1, PGE-1, l-Prostaglandina E1, Alprostadilum, Befar, Caverject, Caverject Impulse, Edex, Muse, Vitaros, Femprox, Topiglan, Alprox-TD, Liprostin, Prostandin, Prostin VR Pediatric, Prostavasin, Lipoprost, Promostan, Prostivas, l-PGE1, PGE1alpha, \u00e1cido (11alfa,13E,15S)-11,15-di-hidroxi-9-oxoprost-13-en-1-oico, (-)-Prostaglandina E1","gt-citation":"[1] Jain A, Leslie SW, Iqbal O. Alprostadil. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542217\/\n\n[2] Anaissie J, Hellstrom WJ. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review. Res Rep Urol. 2016;8:123-131. Published 2016 Aug 3. doi:10.2147\/RRU.S68560\n\n[3] Linet OI, Ogrinc FG. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The Alprostadil Study Group. N Engl J Med. 1996;334(14):873-877. doi:10.1056\/NEJM199604043341401\n\n[4] Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med. 1997;336(1):1-7. doi:10.1056\/NEJM199701023360101\n\n[5] Cai T, Palumbo F, Liguori G, et al. The intra-meatal application of alprostadil cream (Vitaros\u00ae) improves drug efficacy and patient's satisfaction: results from a randomized, two-administration route, cross-over clinical trial. Int J Impot Res. 2019;31(2):119-125. doi:10.1038\/s41443-018-0087-6","gt-clinical-context":"<p>O alprostadil \u00e9 aprovado pelo FDA para a disfun\u00e7\u00e3o er\u00e9til e \u00e9 tipicamente utilizado como tratamento de segunda linha (ou como op\u00e7\u00e3o alternativa de primeira linha em pacientes bem informados) quando as terapias orais de primeira linha, como os inibidores da fosfodiesterase tipo 5 (PDE5) (por exemplo, sildenafila), mostram-se ineficazes.<span class=\"citation\">1<\/span> Pode ser administrado por meio de inje\u00e7\u00e3o intracavernosa, suposit\u00f3rio intrauretral ou creme t\u00f3pico.<span class=\"citation\">2<\/span> O medicamento atua relaxando o tecido muscular liso dos corpos cavernosos, dilatando as art\u00e9rias cavernosas, aumentando o fluxo sangu\u00edneo e levando \u00e0 ere\u00e7\u00e3o.<span class=\"citation\">1<\/span><\/p>\n<p>Para a disfun\u00e7\u00e3o er\u00e9til, o alprostadil est\u00e1 dispon\u00edvel em diversas formula\u00e7\u00f5es:<\/p>\n<ul>\n<li><strong>Inje\u00e7\u00e3o intracavernosa<\/strong>: O alprostadil \u00e9 o \u00fanico agente aprovado pelo FDA para inje\u00e7\u00f5es intracavernosas no tratamento da disfun\u00e7\u00e3o er\u00e9til.<span class=\"citation\">1<\/span> Estudos cl\u00ednicos relatam taxas de efic\u00e1cia superiores a 70% para o alprostadil intracavernoso em homens com disfun\u00e7\u00e3o er\u00e9til.<span class=\"citation\">3<\/span><\/li>\n<li><strong>Suposit\u00f3rio intrauretral<\/strong> (MUSE &#8211; Medicated Urethral System for Erection): Esta alternativa menos invasiva produz ere\u00e7\u00f5es suficientes para a rela\u00e7\u00e3o sexual em aproximadamente 30-66% dos pacientes.<span class=\"citation\">4<\/span><\/li>\n<li><strong>Creme t\u00f3pico<\/strong> (por exemplo, Vitaros): O creme t\u00f3pico de alprostadil provou ser eficaz e bem tolerado, aumentando o escore de fun\u00e7\u00e3o er\u00e9til do \u00cdndice Internacional de Fun\u00e7\u00e3o Er\u00e9til em at\u00e9 13 pontos em rela\u00e7\u00e3o ao valor basal.<span class=\"citation\">2<\/span> Oferece uma op\u00e7\u00e3o menos invasiva com menos efeitos colaterais sist\u00eamicos.<\/li>\n<\/ul>\n<p>O alprostadil tamb\u00e9m pode ser combinado com outros medicamentos, como na formula\u00e7\u00e3o conhecida como &#8220;Trimix&#8221;, que inclui papaverina, fentolamina e alprostadil.<span class=\"citation\">1<\/span> Esta combina\u00e7\u00e3o \u00e9 particularmente eficaz quando administrada por inje\u00e7\u00e3o intracavernosa.<\/p>\n<p>Al\u00e9m da disfun\u00e7\u00e3o er\u00e9til, o alprostadil tamb\u00e9m \u00e9 aprovado pelo FDA para manter temporariamente a permeabilidade do canal arterial em neonatos com cardiopatia cong\u00eanita canal-dependente at\u00e9 a interven\u00e7\u00e3o cir\u00fargica.<span class=\"citation\">1<\/span> Outras aplica\u00e7\u00f5es cl\u00ednicas incluem o manejo de altera\u00e7\u00f5es isqu\u00eamicas em pacientes com fen\u00f4meno de Raynaud, tratamento da neuropatia perif\u00e9rica diab\u00e9tica, preven\u00e7\u00e3o de nefropatia induzida por contraste e p\u00f3s-transplante hep\u00e1tico para melhorar o fluxo vascular hep\u00e1tico e reduzir a les\u00e3o de isquemia-reperfus\u00e3o.<span class=\"citation\">1<\/span><\/p>\n<p>Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes para a terapia com alprostadil geralmente incluem indiv\u00edduos que:<\/p>\n<ul>\n<li>Apresentaram falha ou n\u00e3o toleram inibidores da PDE5 orais<span class=\"citation\">2<\/span><\/li>\n<li>Possuem contraindica\u00e7\u00f5es aos inibidores da PDE5 (por exemplo, uso de nitratos)<span class=\"citation\">1<\/span><\/li>\n<li>Apresentam disfun\u00e7\u00e3o er\u00e9til de diversas etiologias (vasculog\u00eanica, psicog\u00eanica ou causas mistas)<span class=\"citation\">2<\/span><\/li>\n<li>Necessitam de um teste diagn\u00f3stico para disfun\u00e7\u00e3o er\u00e9til<span class=\"citation\">3<\/span><\/li>\n<\/ul>\n","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":true,"gt-view-count":30},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Alprostadil na Disfun\u00e7\u00e3o Er\u00e9til: O que \u00c9 e Como Funciona<\/title>\n<meta name=\"description\" content=\"O alprostadil \u00e9 um an\u00e1logo da PGE1 usado para tratar a disfun\u00e7\u00e3o er\u00e9til quando as terapias orais falham, via inje\u00e7\u00e3o, suposit\u00f3rio ou creme.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/alprostadil\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alprostadil na 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