{"id":32180,"date":"2026-09-04T18:28:00","date_gmt":"2026-09-04T22:28:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32180"},"modified":"2026-09-05T06:08:00","modified_gmt":"2026-09-05T10:08:00","slug":"inibidores-da-pde5","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/inibidores-da-pde5\/","title":{"rendered":"Inibidores da PDE5"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104],"class_list":["post-32180","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series"],"acf":{"gt-definition":"<p>Os inibidores da fosfodiesterase tipo 5 (PDE5) s\u00e3o uma classe de medicamentos que bloqueiam seletivamente a enzima fosfodiesterase tipo 5, encontrada predominantemente no corpo cavernoso do p\u00eanis e na vasculatura pulmonar. Esses f\u00e1rmacos atuam prevenindo a degrada\u00e7\u00e3o do monofosfato de guanosina c\u00edclico (GMPc), prolongando assim a a\u00e7\u00e3o do \u00f3xido n\u00edtrico (NO) e potencializando a vasodilata\u00e7\u00e3o em tecidos espec\u00edficos.<span class=\"citation\">1<\/span><\/p>\n<p>O mecanismo de a\u00e7\u00e3o envolve a inibi\u00e7\u00e3o do s\u00edtio catal\u00edtico da PDE5, que normalmente degrada o GMPc. Ap\u00f3s o est\u00edmulo sexual, impulsos nervosos liberam neurotransmissores nos corpos cavernosos, provocando a produ\u00e7\u00e3o de \u00f3xido n\u00edtrico pelas c\u00e9lulas endoteliais. Esse \u00f3xido n\u00edtrico se difunde para as c\u00e9lulas musculares lisas adjacentes e estimula a forma\u00e7\u00e3o de GMPc, levando \u00e0 vasodilata\u00e7\u00e3o e ao aumento do fluxo sangu\u00edneo peniano.<span class=\"citation\">2<\/span> Os inibidores da PDE5 potencializam esses aumentos end\u00f3genos de GMPc ao inibir sua degrada\u00e7\u00e3o, resultando em ere\u00e7\u00e3o prolongada.<span class=\"citation\">3<\/span><\/p>\n<p>Al\u00e9m de tratar a disfun\u00e7\u00e3o er\u00e9til, esses medicamentos demonstraram efic\u00e1cia no manejo da hipertens\u00e3o arterial pulmonar por causarem vasodilata\u00e7\u00e3o na vasculatura pulmonar, diminuindo assim a resist\u00eancia vascular pulmonar e melhorando a capacidade de exerc\u00edcio.<span class=\"citation\">4<\/span> Eles tamb\u00e9m mostraram benef\u00edcios potenciais em outras condi\u00e7\u00f5es, como sintomas do trato urin\u00e1rio inferior associados \u00e0 hiperplasia prost\u00e1tica benigna, fen\u00f4meno de Raynaud e edema pulmonar de grande altitude.<span class=\"citation\">5<\/span><\/p>\n","gt-synonyms":"Inibidores da PDE-5, Inibidores da fosfodiesterase tipo 5, Inibidores espec\u00edficos de PDE5 para cGMP, Medicamentos para disfun\u00e7\u00e3o er\u00e9til, Agentes anti-impot\u00eancia, Inibidores seletivos da PDE5","gt-citation":"[1] Corbin, J.D. (2004). Mechanisms of action of PDE5 inhibition in erectile dysfunction. International Journal of Impotence Research, 16, S4-S7. DOI: https:\/\/doi.org\/10.1038\/sj.ijir.3901205\n\n[2] Ahmed, W.S., Geethakumari, A.M., & Biswas, K.H. (2021). Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors. Biomedicine & Pharmacotherapy, 134, 111128. DOI: https:\/\/doi.org\/10.1016\/j.biopha.2020.111128\n\n[3] Dhaliwal, A., & Gupta, M. (2023). PDE5 Inhibitors. In StatPearls. StatPearls Publishing. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK549843\/\n\n[4] Andersson, K.E. (2018). PDE5 inhibitors \u2013 pharmacology and clinical applications 20 years after sildenafil discovery. British Journal of Pharmacology, 175(13), 2554-2565. DOI: https:\/\/doi.org\/10.1111\/bph.14205\n\n[5] Phosphodiesterase Type 5 (PDE5) Inhibitors. (2017). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548192\/","gt-clinical-context":"<p>Os inibidores da PDE5 s\u00e3o primariamente recomendados como tratamento de primeira linha para disfun\u00e7\u00e3o er\u00e9til (ED) decorrente de causas psicog\u00eanicas, vasculares e neurop\u00e1ticas quando combinados com terapia espec\u00edfica para a etiologia.<span class=\"citation\">1<\/span> A descoberta desses medicamentos revolucionou o tratamento da ED, oferecendo uma op\u00e7\u00e3o n\u00e3o invasiva e eficaz para milh\u00f5es de homens no mundo todo. Estimativas atuais sugerem que aproximadamente 320 milh\u00f5es de homens apresentar\u00e3o disfun\u00e7\u00e3o er\u00e9til at\u00e9 2025.<span class=\"citation\">2<\/span><\/p>\n<p>Esses medicamentos tamb\u00e9m s\u00e3o indicados para hipertens\u00e3o pulmonar idiop\u00e1tica, particularmente em pacientes nas classes funcionais 2 ou 3 da NYHA com teste de vasorreatividade pulmonar aguda negativo. Eles n\u00e3o s\u00e3o recomendados para pacientes na classe 4 da NYHA, nos quais agonistas da prostaciclina, como epoprostenol e iloprosta, s\u00e3o mais apropriados.<span class=\"citation\">3<\/span><\/p>\n<p>Os inibidores da PDE5 tratam eficazmente a ejacula\u00e7\u00e3o precoce associada \u00e0 disfun\u00e7\u00e3o er\u00e9til, aumentando a lat\u00eancia ejaculat\u00f3ria por meio da inibi\u00e7\u00e3o dos receptores de PDE5 no tecido contr\u00e1til do trato reprodutor masculino.<span class=\"citation\">4<\/span> Al\u00e9m disso, demonstraram efic\u00e1cia no tratamento do mal da montanha ao reduzir a hipertens\u00e3o pulmonar em indiv\u00edduos com press\u00e3o arterial sist\u00f3lica pulmonar elevada induzida pela altitude.<span class=\"citation\">5<\/span><\/p>\n<p>O uso precoce de sildenafila ap\u00f3s prostatectomia radical demonstrou benef\u00edcios no tratamento da ED p\u00f3s-cir\u00fargica devido a efeitos neurorregenerativos no nervo cavernoso, que \u00e9 frequentemente lesionado durante o procedimento.<span class=\"citation\">6<\/span> Para pacientes com sintomas do trato urin\u00e1rio inferior (LUTS) decorrentes de hiperplasia prost\u00e1tica benigna com ED concomitante, esses f\u00e1rmacos reduzem sintomas de hesita\u00e7\u00e3o, urg\u00eancia e polaci\u00faria.<span class=\"citation\">7<\/span><\/p>\n<p>Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes incluem uma avalia\u00e7\u00e3o criteriosa do estado cardiovascular, uma vez que esses medicamentos s\u00e3o contraindicados em pacientes em uso de nitratos devido ao risco de hipotens\u00e3o grave. Devem ser usados com cautela em pacientes com infarto do mioc\u00e1rdio recente, acidente vascular cerebral, arritmias com risco de vida ou angina inst\u00e1vel.<span class=\"citation\">8<\/span> Ajustes de dosagem s\u00e3o necess\u00e1rios para pacientes com insufici\u00eancia hep\u00e1tica ou renal.<span class=\"citation\">9<\/span><\/p>\n<p>Os desfechos esperados da terapia com inibidores da PDE5 incluem melhora da fun\u00e7\u00e3o er\u00e9til, aumento da qualidade de vida e maior satisfa\u00e7\u00e3o com a atividade sexual. As taxas de sucesso variam de 65% a 80% na popula\u00e7\u00e3o geral com ED, com varia\u00e7\u00f5es baseadas na etiologia e comorbidades.<span class=\"citation\">10<\/span> A falha do tratamento pode exigir a considera\u00e7\u00e3o de abordagens alternativas, como inje\u00e7\u00f5es intracavernosas, dispositivos de v\u00e1cuo ou pr\u00f3teses penianas.<\/p>\n","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":true,"gt-view-count":0},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Inibidores da PDE5: Mecanismo de A\u00e7\u00e3o e Uso na Urologia<\/title>\n<meta name=\"description\" content=\"Os inibidores da PDE5 bloqueiam a fosfodiesterase tipo 5 para promover vasodilata\u00e7\u00e3o, tratando a disfun\u00e7\u00e3o er\u00e9til e a hipertens\u00e3o arterial pulmonar.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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