{"id":12864,"date":"2025-08-14T10:18:06","date_gmt":"2025-08-14T14:18:06","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/coaptite\/"},"modified":"2025-08-14T10:18:06","modified_gmt":"2025-08-14T14:18:06","slug":"coaptite","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/coaptite\/","title":{"rendered":"Coaptite"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[123],"glossary-product":[],"class_list":["post-12864","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urinary-incontinence-treatments"],"acf":{"gt-definition":"

Coaptite\u00ae<\/sup> \u00e9 um implante injet\u00e1vel, est\u00e9ril e apirog\u00eanico composto por part\u00edculas esf\u00e9ricas de hidroxilapatita de c\u00e1lcio (CaHA) (75-125 m\u00edcrons de di\u00e2metro), suspensas em um gel transportador de base aquosa.1<\/sup> O gel transportador \u00e9 composto de carboximetilcelulose s\u00f3dica, \u00e1gua est\u00e9ril para inje\u00e7\u00e3o e glicerina.1<\/sup> Este material biocompat\u00edvel \u00e9 injetado por via submucosa no colo da bexiga e\/ou no meio da uretra, criando maior volume de tecido e aumento de tecidos moles.2<\/sup><\/p>\n \n

O objetivo principal do Coaptite \u00e9 tratar a incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) devido \u00e0 defici\u00eancia esfincteriana intr\u00ednseca (ISD) em mulheres adultas.1,2<\/sup> Quando injetado, o transportador de gel suspende as part\u00edculas de CaHA e permite a administra\u00e7\u00e3o atrav\u00e9s de agulhas de inje\u00e7\u00e3o, ap\u00f3s o que se dissipa in vivo.3<\/sup> As part\u00edculas de CaHA permanecem nos locais de inje\u00e7\u00e3o e fornecem volume ao tecido para causar coapta\u00e7\u00e3o do uretra, aumentando a resist\u00eancia uretral ao vazamento de urina.3<\/sup> Este mecanismo cria uma estrutura para poss\u00edvel crescimento interno do tecido, facilitando o desenvolvimento de novo tecido na \u00e1rea injetada.4<\/sup><\/p>\n \n

Coaptite oferece uma op\u00e7\u00e3o de tratamento de longa dura\u00e7\u00e3o, por\u00e9m n\u00e3o permanente, com estudos cl\u00ednicos demonstrando efic\u00e1cia mantida ao longo de 3 anos.4<\/sup> Como agente de volume uretral, oferece uma alternativa menos invasiva \u00e0s interven\u00e7\u00f5es cir\u00fargicas para candidatos apropriados com incontin\u00eancia urin\u00e1ria de esfor\u00e7o.2<\/sup><\/p>\n

O Coaptite \u00e9 um agente de preenchimento uretral composto por microesferas de hidroxiapatita de c\u00e1lcio suspensas em gel de carboximetilcelulose. \u00c9 utilizado para inje\u00e7\u00e3o periuretral no tratamento da incontin\u00eancia urin\u00e1ria de esfor\u00e7o por defici\u00eancia esfincteriana intr\u00ednseca. As microesferas s\u00e3o biocompat\u00edveis e promovem crescimento de tecido aut\u00f3logo ao redor do material, proporcionando efeito duradouro.<\/p>","gt-synonyms":"Agente de volume uretral de hidroxilapatita de c\u00e1lcio, agente de volume uretral CaHA, implante injet\u00e1vel Coaptite\u00ae, material de aumento de tecidos moles de hidroxilapatita de c\u00e1lcio","gt-citation":"[1] U.S. Food and Drug Administration. Summary of Safety and Effectiveness Data: Coaptite. P040047. November 10, 2005. DOI: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf4\/p040047b.pdf\n\n[2] Mayer RD, Dmochowski RR, Appell RA, Sand PK, Klimberg IW, Jacoby K, Graham CW, Snyder JA, Nitti VW, Winters JC. Multicenter prospective randomized 52-week trial of calcium hydroxylapatite versus bovine dermal collagen for treatment of stress urinary incontinence. Urology. 2007 May;69(5):876-80. DOI: 10.1016\/j.urology.2007.01.050\n\n[3] Coaptite Injectable Implant Instructions for Use. Merz Pharmaceuticals, LLC. DOI: https:\/\/www.coaptite.com\/pdfs\/coaptite_IFU.pdf\n\n[4] Merz Pharmaceuticals. Coaptite Urethral Bulking Injection. 2025. https:\/\/www.coaptite.com\/","gt-clinical-context":"

Coaptite \u00e9 usado clinicamente para o tratamento da incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) devido \u00e0 defici\u00eancia esfincteriana intr\u00ednseca (DPI) em mulheres adultas.1<\/sup> Esta condi\u00e7\u00e3o \u00e9 caracterizada por perda involunt\u00e1ria de urina durante atividades f\u00edsicas que aumentam a press\u00e3o abdominal, como tossir, espirrar ou fazer exerc\u00edcios, devido ao enfraquecimento da fun\u00e7\u00e3o do esf\u00edncter uretral.<\/p>\n \n

Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes geralmente incluem mulheres adultas com incontin\u00eancia urin\u00e1ria de esfor\u00e7o documentada devido a DPI sem hipermobilidade uretral associada.2<\/sup> Os candidatos devem ter falhado nos tratamentos conservadores e demonstrado disposi\u00e7\u00e3o para se submeter a procedimentos minimamente invasivos. O procedimento \u00e9 contraindicado em pacientes com hist\u00f3ria significativa de infec\u00e7\u00f5es do trato urin\u00e1rio sem resolu\u00e7\u00e3o, quadros atuais ou agudos de cistite ou uretrite e naqueles com revestimento da mucosa uretral fr\u00e1gil.1<\/sup><\/p>\n \n

O procedimento cir\u00fargico envolve a inje\u00e7\u00e3o de Coaptite por via submucosa no colo da bexiga e\/ou no meio da uretra usando uma agulha pequena de calibre 21 projetada para conforto do paciente.3<\/sup> As marca\u00e7\u00f5es circunferenciais da agulha ajudam a orientar a coloca\u00e7\u00e3o, e o procedimento pode ser realizado sob anestesia local em ambiente ambulatorial. V\u00e1rios locais de inje\u00e7\u00e3o podem ser usados para obter a coapta\u00e7\u00e3o ideal da uretra.<\/p>\n \n

Estudos cl\u00ednicos demonstraram que Coaptite mant\u00e9m altas taxas de sucesso ao longo de 3 anos4<\/sup> com efic\u00e1cia compar\u00e1vel ao col\u00e1geno bovino tradicional.2<\/sup> Em um estudo multic\u00eantrico, prospectivo e randomizado de 52 semanas comparando Coaptite ao col\u00e1geno d\u00e9rmico bovino, 63,4% dos pacientes com Coaptite apresentaram melhora de um grau de Stamey ou mais aos 12 anos. meses.2<\/sup> Al\u00e9m disso, mais pacientes com Coaptite necessitaram de apenas uma inje\u00e7\u00e3o (38,0%) em compara\u00e7\u00e3o com pacientes com col\u00e1geno (26,1%), e o volume total m\u00e9dio de material injetado foi menor para Coaptite do que para col\u00e1geno (4,0 mL versus 6,6 mL).2<\/sup><\/p>\n \n

Os resultados esperados incluem redu\u00e7\u00e3o de perdas urin\u00e1rias, melhoria da qualidade de vida e potencial durabilidade dos resultados em compara\u00e7\u00e3o com outros agentes de volume.2<\/sup> O procedimento oferece uma op\u00e7\u00e3o menos invasiva em compara\u00e7\u00e3o com interven\u00e7\u00f5es cir\u00fargicas, com tempo de recupera\u00e7\u00e3o m\u00ednimo e menos complica\u00e7\u00f5es.4<\/sup><\/p>\n

O procedimento \u00e9 realizado ambulatorialmente sob anestesia local, com inje\u00e7\u00e3o transuretral guiada por cistoscopia. Estudos demonstram melhora em 60-70% dos pacientes. Comparado a outros agentes, o Coaptite tem a vantagem de n\u00e3o migrar significativamente e de n\u00e3o interferir com exames de imagem subsequentes. A EAU classifica os agentes de preenchimento como tratamento de segunda linha para incontin\u00eancia de esfor\u00e7o.<\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":42},"yoast_head":"\nCoaptite: Agente de Preenchimento Uretral | Rigicon<\/title>\n<meta name=\"description\" content=\"Conhe\u00e7a o Coaptite, agente de preenchimento \u00e0 base de hidroxiapatita de c\u00e1lcio para tratamento da incontin\u00eancia urin\u00e1ria de esfor\u00e7o. 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