{"id":12864,"date":"2025-08-14T10:18:06","date_gmt":"2025-08-14T14:18:06","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/coaptite\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"coaptite","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/coaptite\/","title":{"rendered":"Coaptite"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[123],"glossary-product":[],"class_list":["post-12864","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urinary-incontinence-treatments"],"acf":{"gt-definition":"<p>Coaptite<sup>\u00ae<\/sup> \u00e9 um implante injet\u00e1vel, est\u00e9ril e apirog\u00eanico, composto por part\u00edculas esf\u00e9ricas de hidroxiapatita de c\u00e1lcio (CaHA) (75-125 m\u00edcrons de di\u00e2metro), suspensas em um gel carreador de base aquosa.<sup>1<\/sup> O gel carreador \u00e9 composto por carboximetilcelulose s\u00f3dica, \u00e1gua est\u00e9ril para inje\u00e7\u00e3o e glicerina.<sup>1<\/sup> Esse material biocompat\u00edvel \u00e9 injetado na submucosa do colo vesical e\/ou da uretra m\u00e9dia, criando aumento do volume tecidual e aumento de tecidos moles.<sup>2<\/sup><\/p>\n    \n    <p>O principal objetivo do Coaptite \u00e9 tratar a incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) decorrente de defici\u00eancia esfincteriana intr\u00ednseca (DEI) em mulheres adultas.<sup>1,2<\/sup> Quando injetado, o gel carreador mant\u00e9m as part\u00edculas de CaHA em suspens\u00e3o e permite sua administra\u00e7\u00e3o por meio de agulhas de inje\u00e7\u00e3o, ap\u00f3s o que se dissipa in vivo.<sup>3<\/sup> As part\u00edculas de CaHA permanecem nos locais de inje\u00e7\u00e3o e proporcionam aumento de volume tecidual, promovendo a coapta\u00e7\u00e3o da uretra e aumentando a resist\u00eancia uretral ao vazamento de urina.<sup>3<\/sup> Esse mecanismo cria um arcabou\u00e7o para um poss\u00edvel crescimento tecidual, facilitando o desenvolvimento de novo tecido na \u00e1rea injetada.<sup>4<\/sup><\/p>\n    \n    <p>O Coaptite oferece uma op\u00e7\u00e3o de tratamento duradoura, por\u00e9m n\u00e3o permanente, com estudos cl\u00ednicos demonstrando efic\u00e1cia mantida por at\u00e9 3 anos.<sup>4<\/sup> Como agente de preenchimento uretral, oferece uma alternativa menos invasiva \u00e0s interven\u00e7\u00f5es cir\u00fargicas para candidatas adequadas com incontin\u00eancia urin\u00e1ria de esfor\u00e7o.<sup>2<\/sup><\/p>","gt-synonyms":"Agente de volume uretral de hidroxilapatita de c\u00e1lcio, agente de volume uretral CaHA, implante injet\u00e1vel Coaptite\u00ae, material de aumento de tecidos moles de hidroxilapatita de c\u00e1lcio","gt-citation":"[1] U.S. Food and Drug Administration. Summary of Safety and Effectiveness Data: Coaptite. P040047. November 10, 2005. DOI: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf4\/p040047b.pdf\n\n[2] Mayer RD, Dmochowski RR, Appell RA, Sand PK, Klimberg IW, Jacoby K, Graham CW, Snyder JA, Nitti VW, Winters JC. Multicenter prospective randomized 52-week trial of calcium hydroxylapatite versus bovine dermal collagen for treatment of stress urinary incontinence. Urology. 2007 May;69(5):876-80. DOI: 10.1016\/j.urology.2007.01.050\n\n[3] Coaptite Injectable Implant Instructions for Use. Merz Pharmaceuticals, LLC. DOI: https:\/\/www.coaptite.com\/pdfs\/coaptite_IFU.pdf\n\n[4] Merz Pharmaceuticals. Coaptite Urethral Bulking Injection. 2025. https:\/\/www.coaptite.com\/","gt-clinical-context":"<p>O Coaptite \u00e9 utilizado clinicamente no tratamento da incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) decorrente de defici\u00eancia esfincteriana intr\u00ednseca (DEI) em mulheres adultas.<sup>1<\/sup> Essa condi\u00e7\u00e3o caracteriza-se pela perda involunt\u00e1ria de urina durante atividades f\u00edsicas que aumentam a press\u00e3o abdominal, como tossir, espirrar ou praticar exerc\u00edcios, devido ao enfraquecimento da fun\u00e7\u00e3o do esf\u00edncter uretral.<\/p>\n    \n    <p>Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes normalmente incluem mulheres adultas com incontin\u00eancia urin\u00e1ria de esfor\u00e7o documentada decorrente de DEI, sem hipermobilidade uretral associada.<sup>2<\/sup> As candidatas devem ter apresentado falha com tratamentos conservadores e demonstrado disposi\u00e7\u00e3o para se submeter a procedimentos minimamente invasivos. O procedimento \u00e9 contraindicado em pacientes com hist\u00f3rico significativo de infec\u00e7\u00f5es do trato urin\u00e1rio n\u00e3o resolvidas, com quadros atuais ou agudos de cistite ou uretrite e naquelas com revestimento mucoso uretral fr\u00e1gil.<sup>1<\/sup><\/p>\n    \n    <p>O procedimento cir\u00fargico envolve a inje\u00e7\u00e3o do Coaptite na submucosa do colo vesical e\/ou da uretra m\u00e9dia, utilizando uma agulha fina de calibre 21 projetada para o conforto da paciente.<sup>3<\/sup> As marca\u00e7\u00f5es circunferenciais da agulha ajudam a orientar o posicionamento, e o procedimento pode ser realizado sob anestesia local em regime ambulatorial. V\u00e1rios locais de inje\u00e7\u00e3o podem ser utilizados para obter a coapta\u00e7\u00e3o ideal da uretra.<\/p>\n    \n    <p>Estudos cl\u00ednicos demonstraram que o Coaptite mant\u00e9m altas taxas de sucesso ao longo de 3 anos<sup>4<\/sup> com efic\u00e1cia compar\u00e1vel \u00e0 do col\u00e1geno bovino tradicional.<sup>2<\/sup> Em um ensaio multic\u00eantrico, prospectivo e randomizado de 52 semanas comparando o Coaptite ao col\u00e1geno d\u00e9rmico bovino, 63,4% das pacientes tratadas com Coaptite apresentaram melhora de um ou mais graus na escala de Stamey aos 12 meses.<sup>2<\/sup> Al\u00e9m disso, mais pacientes tratadas com Coaptite necessitaram de apenas uma inje\u00e7\u00e3o (38,0%) em compara\u00e7\u00e3o com as pacientes tratadas com col\u00e1geno (26,1%), e o volume total m\u00e9dio de material injetado foi menor com o Coaptite do que com o col\u00e1geno (4,0 mL versus 6,6 mL).<sup>2<\/sup><\/p>\n    \n    <p>Os resultados esperados incluem redu\u00e7\u00e3o da perda urin\u00e1ria, melhora da qualidade de vida e uma melhora potencialmente duradoura.<sup>2<\/sup> O procedimento oferece uma op\u00e7\u00e3o menos invasiva em compara\u00e7\u00e3o com as interven\u00e7\u00f5es cir\u00fargicas, com tempo de recupera\u00e7\u00e3o m\u00ednimo e menos complica\u00e7\u00f5es.<sup>4<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":74},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Coaptite: Agente de Preenchimento Uretral | Rigicon<\/title>\n<meta name=\"description\" content=\"Conhe\u00e7a o Coaptite, agente de preenchimento \u00e0 base de hidroxiapatita de c\u00e1lcio para tratamento da incontin\u00eancia urin\u00e1ria de esfor\u00e7o. 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