{"id":12862,"date":"2025-08-14T10:17:29","date_gmt":"2025-08-14T14:17:29","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/macroplastique\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"macroplastique","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/macroplastique\/","title":{"rendered":"Macroplastique"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[123],"glossary-product":[],"class_list":["post-12862","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urinary-incontinence-treatments"],"acf":{"gt-definition":"<p>O Macroplastique \u00e9 um agente de preenchimento uretral injet\u00e1vel, apirog\u00eanico e implantado de forma permanente, composto de part\u00edculas de polidimetilsiloxano (elast\u00f4mero de silicone) suspensas em um gel carreador de polivinilpirrolidona (PVP)<sup>1<\/sup>. Esse tratamento minimamente invasivo \u00e9 utilizado principalmente para a incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) decorrente de defici\u00eancia esfincteriana intr\u00ednseca (DEI)<sup>2<\/sup>. O carreador de PVP \u00e9 hidrossol\u00favel e \u00e9 absorvido e eliminado do organismo pela urina, enquanto as part\u00edculas reticuladas de polidimetilsiloxano permanecem permanentemente no local<sup>3<\/sup>. Quando injetado na submucosa uretral, o Macroplastique cria aumento do volume tecidual ao redor da uretra, resultando em maior press\u00e3o de fechamento uretral e redu\u00e7\u00e3o da perda urin\u00e1ria durante atividades f\u00edsicas<sup>4<\/sup>. Os implantes de elast\u00f4mero grandes e com textura acentuada promovem o crescimento tecidual para o seu interior, criando um bolo envolvido e infiltrado pelo col\u00e1geno do hospedeiro, que o ancora no espa\u00e7o entre a l\u00e2mina pr\u00f3pria e a camada muscular da uretra<sup>5<\/sup>.<\/p>","gt-synonyms":"Inje\u00e7\u00e3o de polidimetilsiloxano, agente de volume uretral PDMS, microimplantes de silicone, MPQ","gt-citation":"[1] Ghoniem GM, Miller CJ. A systematic review and meta-analysis of Macroplastique for treating female stress urinary incontinence. Int Urogynecol J. 2012 Jun;24(1):27-36. DOI: 10.1007\/s00192-012-1825-9\n\n[2] Herforth C, Zimmern PE. Macroplastique\u00ae for stress urinary incontinence lights up as a PET-avid urethral lesion: A case report. Case Rep Womens Health. 2024 Sep;43:e00649. DOI: 10.1016\/j.crwh.2024.e00649\n\n[3] Ghoniem G, Farhan B, Chowdhury ML, Chen Y. Safety and efficacy of polydimethylsiloxane (Macroplastique\u00ae) in women with stress urinary incontinence: analysis of data from patients who completed three years follow-up. Int Urogynecol J. 2021 Oct;32(10):2835-2840. DOI: 10.1007\/s00192-021-04827-6. PMID: 34100973\n\n[4] U.S. Food and Drug Administration. Summary of Safety and Effectiveness Data: Macroplastique\u00ae Implants. PMA Number: P040050. October 30, 2006. https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf4\/p040050b.pdf\n\n[5] Serati M, Braga A, Caccia G, et al. Does the Polydimethylsiloxane Urethral Injection (Macroplastique\u00ae) Improve Sexual Function in Women with Stress Urinary Incontinence? A Prospective Study. Medicina. 2023;59(3):580. DOI: 10.3390\/medicina59030580","gt-clinical-context":"<p>O Macroplastique \u00e9 clinicamente indicado para inje\u00e7\u00e3o transuretral no tratamento de mulheres adultas diagnosticadas com incontin\u00eancia urin\u00e1ria de esfor\u00e7o (IUE) decorrente principalmente de defici\u00eancia esfincteriana intr\u00ednseca (DEI)<sup>1<\/sup>. Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes normalmente incluem mulheres com IUE que n\u00e3o obtiveram sucesso com tratamentos conservadores ou que preferem uma op\u00e7\u00e3o minimamente invasiva em vez de procedimentos cir\u00fargicos mais extensos<sup>2<\/sup>. \u00c9 particularmente adequado para pacientes idosas e para aquelas com maior risco de complica\u00e7\u00f5es anest\u00e9sicas<sup>3<\/sup>.<\/p>\n    \n    <p>O procedimento \u00e9 realizado sob anestesia local em regime ambulatorial<sup>4<\/sup>. Antes do procedimento, as pacientes recebem antibi\u00f3ticos para reduzir o risco de infec\u00e7\u00e3o. A inje\u00e7\u00e3o \u00e9 realizada sob visualiza\u00e7\u00e3o cistosc\u00f3pica, com o Macroplastique sendo injetado na submucosa uretral at\u00e9 que se obtenha a coapta\u00e7\u00e3o uretral<sup>5<\/sup>. O procedimento normalmente leva menos de 30 minutos, e a maioria das pacientes pode voltar para casa no mesmo dia.<\/p>\n    \n    <p>Estudos cl\u00ednicos demonstraram taxas de melhora de 75% a curto prazo (&lt;6 meses), 73% a m\u00e9dio prazo (6-18 meses) e 64% a longo prazo (&gt;18 meses)<sup>1<\/sup>. As taxas de cura completa ou de contin\u00eancia total (aus\u00eancia de perdas) foram relatadas como 43%, 37% e 36% nos mesmos respectivos per\u00edodos de acompanhamento<sup>1<\/sup>. Algumas pacientes necessitam de nova inje\u00e7\u00e3o para obter resultados ideais, sendo as taxas mais altas de reinje\u00e7\u00e3o associadas a melhores resultados a longo prazo<sup>1<\/sup>. De acordo com o fabricante, o Macroplastique foi utilizado em mais de 70.000 pacientes desde 1991, e estudos publicados relatam uma baixa taxa de efeitos colaterais<sup>4<\/sup>.<\/p>\n    \n    <p>As contraindica\u00e7\u00f5es incluem inflama\u00e7\u00e3o ou infec\u00e7\u00e3o aguda do trato urogenital e revestimento mucoso uretral fr\u00e1gil (por exemplo, ap\u00f3s radioterapia ou ap\u00f3s cirurgia do colo vesical)<sup>5<\/sup>.<\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":206},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Macroplastique: Tratamento da Incontin\u00eancia Urin\u00e1ria | Rigicon<\/title>\n<meta name=\"description\" content=\"Saiba sobre Macroplastique, agente de preenchimento de silicone para inje\u00e7\u00e3o periuretral no tratamento da incontin\u00eancia de esfor\u00e7o. 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