{"id":12792,"date":"2025-07-31T10:48:49","date_gmt":"2025-07-31T14:48:49","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/leukocytospermia\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"leucocitospermia-pt-br","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/leucocitospermia-pt-br\/","title":{"rendered":"Leucocitospermia"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[126],"glossary-product":[],"class_list":["post-12792","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-conditions"],"acf":{"gt-definition":"<p>A leucocitospermia \u00e9 definida como a presen\u00e7a de uma concentra\u00e7\u00e3o anormalmente elevada de gl\u00f3bulos brancos (leuc\u00f3citos) no s\u00eamen, especificamente acima de 1 \u00d7 10<sup>6<\/sup> leuc\u00f3citos por mililitro de ejaculado, segundo os crit\u00e9rios da Organiza\u00e7\u00e3o Mundial da Sa\u00fade.<sup>1<\/sup> Essa condi\u00e7\u00e3o representa um estado inflamat\u00f3rio no trato reprodutivo masculino que pode indicar infec\u00e7\u00e3o, inflama\u00e7\u00e3o ou outros processos patol\u00f3gicos subjacentes.<sup>2<\/sup> A presen\u00e7a excessiva de leuc\u00f3citos pode gerar esp\u00e9cies reativas de oxig\u00eanio (EROs), que podem danificar as membranas dos espermatozoides, prejudicar a fun\u00e7\u00e3o esperm\u00e1tica e potencialmente comprometer os resultados de fertilidade.<sup>3<\/sup> A leucocitospermia \u00e9 encontrada tanto em homens f\u00e9rteis quanto inf\u00e9rteis, embora pare\u00e7a ser mais frequente neste \u00faltimo grupo, afetando aproximadamente 30% dos homens inf\u00e9rteis.<sup>4<\/sup><\/p>","gt-synonyms":"Leucospermia, Piospermia","gt-citation":"[1] World Health Organization. (2010). WHO laboratory manual for the examination and processing of human semen, 5th ed. Geneva: World Health Organization. https:\/\/iris.who.int\/handle\/10665\/44261\n\n[2] Khodamoradi K, Kuchakulla M, Narasimman M, et al. (2020). Laboratory and clinical management of leukocytospermia and hematospermia: a review. Therapeutic Advances in Reproductive Health, 14:2633494120922511. DOI: 10.1177\/2633494120922511\n\n[3] Sandoval JS, Raburn D, Muasher S. (2013). Leukocytospermia: Overview of diagnosis, implications, and management of a controversial finding. Middle East Fertility Society Journal, 18(3):129-134. DOI: 10.1016\/j.mefs.2013.02.004\n\n[4] Jung JH, Kim MH, Kim J, et al. (2016). Treatment of Leukocytospermia in Male Infertility: A Systematic Review. World Journal of Men's Health, 34(3):165-172. DOI: 10.5534\/wjmh.2016.34.3.165\n\n[5] Ricci G, Perticarari S, Fragonas E, et al. (2009). Leukocytospermia and sperm preparation - a flow cytometric study. Reproductive Biology and Endocrinology, 7:128. DOI: 10.1186\/1477-7827-7-128","gt-clinical-context":"<p>A leucocitospermia \u00e9 clinicamente relevante na avalia\u00e7\u00e3o e no manejo da infertilidade masculina.<sup>1<\/sup> A condi\u00e7\u00e3o \u00e9 diagnosticada por diversos m\u00e9todos, sendo a colora\u00e7\u00e3o imuno-histoqu\u00edmica com anticorpos monoclonais considerada o padr\u00e3o-ouro, embora a colora\u00e7\u00e3o por peroxidase seja mais utilizada na pr\u00e1tica cl\u00ednica por sua praticidade.<sup>2<\/sup> Outras abordagens diagn\u00f3sticas incluem o teste de Endtz, a citometria de fluxo e a dosagem de elastase granulocit\u00e1ria seminal.<sup>3<\/sup><\/p>\n    \n    <p>A etiologia da leucocitospermia \u00e9 multifatorial e inclui infec\u00e7\u00f5es do trato genital (bacterianas ou virais), inflama\u00e7\u00e3o sem infec\u00e7\u00e3o, varicocele, tabagismo e traumas, como les\u00e3o da medula espinhal.<sup>4<\/sup> Curiosamente, em aproximadamente 80% dos homens inf\u00e9rteis com leucocitospermia, nenhuma infec\u00e7\u00e3o microbiana pode ser detectada, apesar da resposta inflamat\u00f3ria.<sup>2<\/sup><\/p>\n    \n    <p>Clinicamente, a leucocitospermia tem sido associada a comprometimento da espermatog\u00eanese, redu\u00e7\u00e3o da motilidade esperm\u00e1tica, defeitos na fun\u00e7\u00e3o da cauda do espermatozoide e taxas mais elevadas de teratoastenozoospermia e necrozoospermia.<sup>2<\/sup> A condi\u00e7\u00e3o pode prejudicar o potencial de fertiliza\u00e7\u00e3o dos espermatozoides ao interferir na rea\u00e7\u00e3o across\u00f4mica e nos processos de fus\u00e3o entre espermatozoide e \u00f3vulo.<sup>3<\/sup> O principal mecanismo de dano parece ser mediado por esp\u00e9cies reativas de oxig\u00eanio geradas pelos leuc\u00f3citos, que podem causar peroxida\u00e7\u00e3o lip\u00eddica das membranas dos espermatozoides, ricas em \u00e1cidos graxos poli-insaturados.<sup>3<\/sup><\/p>\n    \n    <p>As abordagens terap\u00eauticas variam conforme a etiologia suspeita e incluem antibi\u00f3ticos (tetraciclinas, quinolonas, macrol\u00eddeos) nos casos de suspeita de infec\u00e7\u00e3o, agentes anti-inflamat\u00f3rios, antioxidantes e mudan\u00e7as no estilo de vida, como a cessa\u00e7\u00e3o do tabagismo.<sup>5<\/sup> Nos casos em que a leucocitospermia afeta os resultados de fertilidade, t\u00e9cnicas de reprodu\u00e7\u00e3o assistida podem ser consideradas, com aten\u00e7\u00e3o especial \u00e0s t\u00e9cnicas de preparo seminal capazes de separar os espermatozoides dos gl\u00f3bulos brancos.<sup>4<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":274},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Leucocitospermia: Leuc\u00f3citos no S\u00eamen | Rigicon<\/title>\n<meta name=\"description\" content=\"Conhe\u00e7a a leucocitospermia, presen\u00e7a elevada de leuc\u00f3citos no s\u00eamen. 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