{"id":12782,"date":"2025-07-25T10:00:22","date_gmt":"2025-07-25T14:00:22","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/hyperoxaluria\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"hiperoxaluria-pt-br","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/hiperoxaluria-pt-br\/","title":{"rendered":"Hiperoxal\u00faria"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[126],"glossary-product":[],"class_list":["post-12782","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-conditions"],"acf":{"gt-definition":"<p>\n        A hiperoxal\u00faria \u00e9 um dist\u00farbio metab\u00f3lico caracterizado pela excre\u00e7\u00e3o excessiva de oxalato na urina, normalmente definida como excre\u00e7\u00e3o urin\u00e1ria de oxalato superior a 40 mg (440 \u03bcmol) em 24 horas.<sup class=\"citation\">1<\/sup> O oxalato \u00e9 uma subst\u00e2ncia qu\u00edmica natural produzida pelo organismo e encontrada em certos alimentos que, quando presente em altas concentra\u00e7\u00f5es, forma cristais com o c\u00e1lcio nos rins.<sup class=\"citation\">2<\/sup> Esses cristais de oxalato de c\u00e1lcio podem levar \u00e0 forma\u00e7\u00e3o de c\u00e1lculos renais, \u00e0 nefrocalcinose (dep\u00f3sitos de c\u00e1lcio no tecido renal) e, nos casos graves, a dano e insufici\u00eancia renais.<sup class=\"citation\">3<\/sup> A hiperoxal\u00faria pode ser classificada em formas prim\u00e1rias (dist\u00farbios gen\u00e9ticos heredit\u00e1rios do metabolismo do glioxilato) e formas secund\u00e1rias (decorrentes do aumento da ingest\u00e3o alimentar ou da absor\u00e7\u00e3o intestinal de oxalato).<sup class=\"citation\">4<\/sup>\n    <\/p>","gt-synonyms":"Oxal\u00faria, Hiperoxalose (quando se refere \u00e0 deposi\u00e7\u00e3o sist\u00eamica de oxalato), Hiperoxal\u00faria prim\u00e1ria (PH1, PH2, PH3 para formas gen\u00e9ticas), Hiperoxal\u00faria ent\u00e9rica, Hiperoxal\u00faria diet\u00e9tica, Hiperoxal\u00faria idiop\u00e1tica","gt-citation":"[1] Shah A, Leslie SW, Ramakrishnan S. Hyperoxaluria. StatPearls. 2024 Mar 4. PMID: 32644413. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK558987\/\n\n[2] Groothoff JW, Metry E, Deesker L, et al. Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope. Nat Rev Nephrol. 2023;19:194-211. DOI: 10.1038\/s41581-022-00661-1\n\n[3] Bhasin B, \u00dcrekli HM, Atta MG. Primary and secondary hyperoxaluria: Understanding the enigma. World J Nephrol. 2015;4(2):235-244. DOI: 10.5527\/wjn.v4.i2.235\n\n[4] Demoulin N, Aydin S, Gillion V, et al. Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review. Am J Kidney Dis. 2022;79(5):717-727. DOI: 10.1053\/j.ajkd.2021.07.018. PMID: 34508834","gt-clinical-context":"<p>\n        A hiperoxal\u00faria contribui de forma significativa para a nefrolit\u00edase (c\u00e1lculos renais), sendo o oxalato urin\u00e1rio o promotor qu\u00edmico mais potente da forma\u00e7\u00e3o de c\u00e1lculos renais.<sup class=\"citation\">1<\/sup> A apresenta\u00e7\u00e3o cl\u00ednica varia de acordo com o tipo e a gravidade da hiperoxal\u00faria, mas as manifesta\u00e7\u00f5es comuns incluem c\u00e1lculos renais recorrentes, hemat\u00faria (sangue na urina), infec\u00e7\u00f5es do trato urin\u00e1rio e dor no flanco.<sup class=\"citation\">2<\/sup>\n    <\/p>\n    \n    <p>\n        A hiperoxal\u00faria prim\u00e1ria (HP) \u00e9 um dist\u00farbio heredit\u00e1rio raro com tr\u00eas tipos principais (HP1, HP2, HP3), cada um causado por diferentes muta\u00e7\u00f5es gen\u00e9ticas que afetam enzimas hep\u00e1ticas envolvidas no metabolismo do glioxilato.<sup class=\"citation\">3<\/sup> A HP1, a forma mais grave, \u00e9 causada por muta\u00e7\u00f5es no gene AGXT, que resultam em defici\u00eancia da atividade da alanina-glioxilato aminotransferase.<sup class=\"citation\">4<\/sup> Sem tratamento, a HP1 frequentemente progride para doen\u00e7a renal em est\u00e1gio terminal (DRET) na inf\u00e2ncia ou no in\u00edcio da vida adulta.<sup class=\"citation\">5<\/sup>\n    <\/p>\n    \n    <p>\n        A hiperoxal\u00faria secund\u00e1ria inclui a hiperoxal\u00faria ent\u00e9rica (decorrente de doen\u00e7as intestinais, como a doen\u00e7a de Crohn, ou ap\u00f3s cirurgia bari\u00e1trica), a hiperoxal\u00faria diet\u00e9tica (pelo consumo excessivo de alimentos ricos em oxalato) e a hiperoxal\u00faria idiop\u00e1tica.<sup class=\"citation\">6<\/sup>\n    <\/p>\n    \n    <p>\n        As estrat\u00e9gias de manejo dependem da causa subjacente e da gravidade, mas geralmente incluem aumento da ingest\u00e3o de l\u00edquidos (visando um d\u00e9bito urin\u00e1rio &gt;3L por dia), restri\u00e7\u00e3o de oxalato na dieta, suplementa\u00e7\u00e3o de c\u00e1lcio \u00e0s refei\u00e7\u00f5es, alcaliniza\u00e7\u00e3o urin\u00e1ria com citrato de pot\u00e1ssio e, nos casos graves, tratamentos especializados, como a piridoxina (vitamina B6) para pacientes com HP1 responsivos.<sup class=\"citation\">7<\/sup> Para a hiperoxal\u00faria prim\u00e1ria, terapias mais recentes de interfer\u00eancia por RNA, como o lumasirana, mostraram-se promissoras na redu\u00e7\u00e3o da produ\u00e7\u00e3o de oxalato.<sup class=\"citation\">8<\/sup> Em casos avan\u00e7ados com insufici\u00eancia renal, podem ser necess\u00e1rios di\u00e1lise intensiva e transplante combinado de f\u00edgado e rim, particularmente na HP1.<sup class=\"citation\">9<\/sup>\n    <\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":128},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hiperoxal\u00faria: Excesso de Oxalato e C\u00e1lculos Renais | Rigicon<\/title>\n<meta name=\"description\" content=\"Conhe\u00e7a a hiperoxal\u00faria, excre\u00e7\u00e3o excessiva de oxalato urin\u00e1rio associada a c\u00e1lculos renais de oxalato de c\u00e1lcio. 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