{"id":12778,"date":"2025-07-25T09:58:14","date_gmt":"2025-07-25T13:58:14","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/hormone-therapy\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"terapia-hormonal-pt-br","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/terapia-hormonal-pt-br\/","title":{"rendered":"Terapia Hormonal"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[137],"glossary-product":[],"class_list":["post-12778","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-hormone-therapy"],"acf":{"gt-definition":"<p>\n        A terapia hormonal, tamb\u00e9m chamada de terapia de priva\u00e7\u00e3o androg\u00eanica (ADT), \u00e9 uma abordagem terap\u00eautica que visa reduzir os n\u00edveis de horm\u00f4nios masculinos (andr\u00f3genos) no organismo ou impedir que eles estimulem o crescimento das c\u00e9lulas do c\u00e2ncer de pr\u00f3stata.<span class=\"citation\">1<\/span> Essa estrat\u00e9gia terap\u00eautica atua impedindo o organismo de produzir testosterona, bloqueando a a\u00e7\u00e3o dos andr\u00f3genos em todo o corpo ou inibindo a produ\u00e7\u00e3o de andr\u00f3genos em diversos tecidos, incluindo as pr\u00f3prias c\u00e9lulas do c\u00e2ncer de pr\u00f3stata.<span class=\"citation\">2<\/span> A terapia hormonal consolidou-se como tratamento fundamental do c\u00e2ncer de pr\u00f3stata depois que Huggins e Hodges demonstraram o efeito terap\u00eautico da priva\u00e7\u00e3o de testosterona gonadal na d\u00e9cada de 1940, estabelecendo firmemente o c\u00e2ncer de pr\u00f3stata como uma doen\u00e7a altamente dependente de andr\u00f3genos.<span class=\"citation\">3<\/span> Embora a terapia hormonal possa fazer com que os c\u00e2nceres de pr\u00f3stata diminuam ou cres\u00e7am mais lentamente por algum tempo, ela, isoladamente, n\u00e3o cura o c\u00e2ncer de pr\u00f3stata, e muitos c\u00e2nceres acabam se tornando resistentes \u00e0 terapia hormonal.<span class=\"citation\">1<\/span>\n    <\/p>","gt-synonyms":"Terapia de priva\u00e7\u00e3o androg\u00eanica (ADT), terapia de supress\u00e3o androg\u00eanica, castra\u00e7\u00e3o m\u00e9dica, castra\u00e7\u00e3o qu\u00edmica, terapia hormonal, terapia de bloqueio androg\u00eanico, bloqueio androg\u00eanico combinado, bloqueio androg\u00eanico completo, bloqueio androg\u00eanico m\u00e1ximo, bloqueio androg\u00eanico total","gt-citation":"[1] American Cancer Society. Hormone Therapy for Prostate Cancer. https:\/\/www.cancer.org\/cancer\/types\/prostate-cancer\/treating\/hormone-therapy.html\n\n[2] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet.\n\n[3] Desai K, McManus JM, Sharifi N. Hormonal Therapy for Prostate Cancer. Endocr Rev. 2021 May 25;42(3):354-373. DOI: 10.1210\/endrev\/bnab002. PMID: 33480983\n\n[4] Schaeffer EM, Srinivas S, Adra N, et al. Prostate Cancer, Version 4.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023 Oct;21(10):1067-1096. DOI: 10.6004\/jnccn.2023.0050. PMID: 37856213","gt-clinical-context":"<p>\n        A terapia hormonal \u00e9 clinicamente indicada em diversos cen\u00e1rios no manejo do c\u00e2ncer de pr\u00f3stata.<span class=\"citation\">1<\/span> Pode ser utilizada juntamente com a radioterapia como primeiro tratamento para o c\u00e2ncer que ainda est\u00e1 na pr\u00f3stata ou ao seu redor e que apresenta maior risco de recidiva.<span class=\"citation\">1,4<\/span> Tamb\u00e9m pode ser administrada antes da radioterapia para reduzir o tamanho do c\u00e2ncer e tornar o tratamento mais eficaz.<span class=\"citation\">1<\/span> Para pacientes cujo c\u00e2ncer persiste ou retorna ap\u00f3s o tratamento com cirurgia ou radioterapia, a terapia hormonal \u00e9 frequentemente recomendada, especialmente se o c\u00e2ncer tiver se disseminado.<span class=\"citation\">1,3<\/span> Al\u00e9m disso, a terapia hormonal \u00e9 o padr\u00e3o de tratamento quando o c\u00e2ncer de pr\u00f3stata j\u00e1 se disseminou demais para ser curado por cirurgia ou radioterapia.<span class=\"citation\">1,4<\/span>\n    <\/p>\n    <p>\n        Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes incluem aqueles com doen\u00e7a localizada de alto risco, recidiva bioqu\u00edmica ap\u00f3s a terapia prim\u00e1ria e doen\u00e7a metast\u00e1tica.<span class=\"citation\">3,4<\/span> A abordagem terap\u00eautica varia de acordo com o est\u00e1gio da doen\u00e7a, com diferentes combina\u00e7\u00f5es de agentes de terapia hormonal utilizadas no c\u00e2ncer de pr\u00f3stata horm\u00f4nio-sens\u00edvel e no resistente \u00e0 castra\u00e7\u00e3o.<span class=\"citation\">2,3<\/span> Os resultados esperados incluem o controle da doen\u00e7a e o prolongamento da sobrevida, embora os efeitos colaterais precisem ser manejados com cuidado.<span class=\"citation\">1,3<\/span> Avan\u00e7os cl\u00ednicos recentes demonstraram que a combina\u00e7\u00e3o da terapia hormonal com outros tratamentos, como quimioterapia ou agentes hormonais de segunda gera\u00e7\u00e3o, pode melhorar significativamente a sobrevida no c\u00e2ncer de pr\u00f3stata metast\u00e1tico horm\u00f4nio-sens\u00edvel.<span class=\"citation\">3,4<\/span>\n    <\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":118},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Terapia Hormonal na Urologia: Indica\u00e7\u00f5es e Manejo | Rigicon<\/title>\n<meta name=\"description\" content=\"Guia sobre terapia hormonal na urologia: TRT para hipogonadismo, TDA para c\u00e2ncer de pr\u00f3stata e tratamento de infertilidade. 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