{"id":12749,"date":"2025-07-23T10:37:26","date_gmt":"2025-07-23T14:37:26","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/chancre\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"cancro","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/cancro\/","title":{"rendered":"Cancro"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[126],"glossary-product":[],"class_list":["post-12749","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-conditions"],"acf":{"gt-definition":"<p>O cancro \u00e9 uma \u00falcera indolor, firme e arredondada que se forma no local de entrada da bact\u00e9ria <i>Treponema pallidum<\/i>, representando a les\u00e3o prim\u00e1ria e a primeira manifesta\u00e7\u00e3o cl\u00ednica da infec\u00e7\u00e3o por s\u00edfilis.<sup>1<\/sup> O cancro normalmente aparece aproximadamente 3 semanas (intervalo de 10-90 dias) ap\u00f3s a exposi\u00e7\u00e3o ao organismo infeccioso.<sup>2<\/sup> Come\u00e7a como uma p\u00e1pula que rapidamente sofre eros\u00e3o, formando uma \u00falcera de base limpa, n\u00e3o exsudativa, com bordas elevadas e endurecidas, medindo aproximadamente 1-2 cm de di\u00e2metro.<sup>3<\/sup> A les\u00e3o cont\u00e9m numerosas espiroquetas, o que a torna altamente contagiosa, e geralmente \u00e9 acompanhada de linfadenopatia regional.<sup>4<\/sup> Sem tratamento, o cancro cicatriza espontaneamente em 3-6 semanas, deixando cicatriz m\u00ednima ou nenhuma, mas a infec\u00e7\u00e3o progride para s\u00edfilis secund\u00e1ria \u00e0 medida que as bact\u00e9rias se disseminam pelo corpo.<sup>5<\/sup><\/p>","gt-synonyms":"\u00dalcera sifil\u00edtica prim\u00e1ria, cancro duro, cancro Hunteriano, les\u00e3o prim\u00e1ria sifil\u00edtica, sifiloma prim\u00e1rio","gt-citation":"[1] Singh AE, Romanowski B. Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features. Clin Microbiol Rev. 1999 Apr;12(2):187-209. DOI: 10.1128\/cmr.12.2.187\n\n[2] Tiecco G, Degli Antoni M, Storti S, et al. A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines. Pathogens. 2021;10(11):1364. DOI: 10.3390\/pathogens10111364. PMID: 34832520\n\n[3] Read PJ, Donovan B. Clinical aspects of adult syphilis. Intern Med J. 2012;42(6):614-620. DOI: 10.1111\/j.1445-5994.2012.02814.x\n\n[4] Peeling RW, Mabey D, Kamb ML, et al. Syphilis. Nat Rev Dis Primers. 2017;3:17073. DOI: 10.1038\/nrdp.2017.73\n\n[5] Hook EW 3rd. Syphilis. Lancet. 2017;389(10078):1550-1557. DOI: 10.1016\/S0140-6736(16)32411-4","gt-clinical-context":"<p>Os cancros s\u00e3o clinicamente significativos, pois representam a manifesta\u00e7\u00e3o inicial da s\u00edfilis prim\u00e1ria, uma infec\u00e7\u00e3o sexualmente transmiss\u00edvel causada pela bact\u00e9ria espiroqueta <i>Treponema pallidum<\/i>.<sup>1<\/sup> A les\u00e3o normalmente aparece no local da inocula\u00e7\u00e3o, mais comumente na genit\u00e1lia, mas tamb\u00e9m pode ocorrer nos l\u00e1bios, l\u00edngua, faringe, reto ou outros locais de contato sexual.<sup>2<\/sup> Nas mulheres, os cancros podem se desenvolver no colo do \u00fatero ou dentro da vagina, muitas vezes passando despercebidos devido \u00e0 sua natureza indolor e \u00e0 localiza\u00e7\u00e3o interna.<sup>3<\/sup><\/p>\n    \n    <p>Clinicamente, os cancros s\u00e3o marcadores diagn\u00f3sticos importantes que devem motivar testagem e tratamento imediatos. A presen\u00e7a de um cancro indica s\u00edfilis ativa e altamente infecciosa, que pode ser facilmente transmitida por contato direto com a les\u00e3o.<sup>4<\/sup> A linfadenopatia regional, caracterizada por linfonodos firmes, el\u00e1sticos e indolores, est\u00e1 presente em at\u00e9 80% dos pacientes com s\u00edfilis prim\u00e1ria.<sup>5<\/sup><\/p>\n    \n    <p>O diagn\u00f3stico normalmente \u00e9 confirmado por microscopia de campo escuro do exsudato da les\u00e3o, que pode demonstrar as espiroquetas caracter\u00edsticas com movimento em saca-rolhas, ou, mais comumente, por testes sorol\u00f3gicos.<sup>1<\/sup> \u00c9 importante observar que, enquanto o cancro est\u00e1 se desenvolvendo, os testes sorol\u00f3gicos ainda podem ser negativos, sendo necess\u00e1rio repetir os testes se a suspeita cl\u00ednica for alta.<sup>4<\/sup><\/p>\n    \n    <p>O tratamento da s\u00edfilis prim\u00e1ria com cancro consiste em penicilina G benzatina 2,4 milh\u00f5es de unidades, administrada por via intramuscular em dose \u00fanica.<sup>2<\/sup> O tratamento precoce \u00e9 crucial para prevenir a progress\u00e3o para os est\u00e1gios secund\u00e1rio e terci\u00e1rio da s\u00edfilis, que podem levar a complica\u00e7\u00f5es cardiovasculares, neurol\u00f3gicas e outras complica\u00e7\u00f5es sist\u00eamicas significativas.<sup>3<\/sup> Para pacientes al\u00e9rgicos \u00e0 penicilina, os esquemas alternativos incluem doxiciclina ou tetraciclina, embora as evid\u00eancias que apoiam essas alternativas sejam mais limitadas e o acompanhamento cl\u00ednico e sorol\u00f3gico rigoroso seja essencial.<sup>5<\/sup><\/p>\n    \n    <p>Os profissionais de sa\u00fade devem manter um alto \u00edndice de suspeita de s\u00edfilis em pacientes que apresentam \u00falceras genitais, particularmente as indolores, pois o diagn\u00f3stico e o tratamento precoces s\u00e3o essenciais para prevenir a transmiss\u00e3o e as complica\u00e7\u00f5es.<sup>1<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":78},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cancro Duro: Causas, Aspecto e Diagn\u00f3stico Diferencial | Rigicon<\/title>\n<meta name=\"description\" content=\"Saiba sobre o cancro duro, les\u00e3o da s\u00edfilis prim\u00e1ria: aspecto, diagn\u00f3stico diferencial com outras \u00falceras genitais e manejo cl\u00ednico.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/cancro\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancro - Prosthetic Urology Glossary\" \/>\n<meta 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