{"id":12743,"date":"2025-07-22T08:29:16","date_gmt":"2025-07-22T12:29:16","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/autologous\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"autologo-pt-br","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/autologo-pt-br\/","title":{"rendered":"Aut\u00f3logo"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[112],"glossary-product":[],"class_list":["post-12743","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-surgical-procedures"],"acf":{"gt-definition":"<p>Aut\u00f3logo refere-se a um procedimento ou tratamento m\u00e9dico no qual c\u00e9lulas, tecidos ou outros materiais biol\u00f3gicos s\u00e3o obtidos do mesmo indiv\u00edduo que ir\u00e1 receb\u00ea-los.<sup>1<\/sup> O termo tem origem nas ra\u00edzes gregas \"auto\" (pr\u00f3prio) e \"logos\" (rela\u00e7\u00e3o), significando essencialmente \"relativo a si mesmo\".<sup>2<\/sup> Em contextos m\u00e9dicos, os procedimentos aut\u00f3logos envolvem a coleta, o processamento e a posterior reintrodu\u00e7\u00e3o dos pr\u00f3prios materiais biol\u00f3gicos do paciente em seu corpo para fins terap\u00eauticos.<sup>3<\/sup><\/p>\n    \n    <p>Os tratamentos aut\u00f3logos distinguem-se pelo fato de o doador e o receptor serem a mesma pessoa, eliminando as preocupa\u00e7\u00f5es com incompatibilidade imunol\u00f3gica ou rejei\u00e7\u00e3o que podem ocorrer com materiais de outros indiv\u00edduos.<sup>4<\/sup> Essa abordagem \u00e9 comumente utilizada em diversas \u00e1reas m\u00e9dicas, incluindo hematologia, oncologia, ortopedia e medicina regenerativa, nas quais as pr\u00f3prias c\u00e9lulas ou tecidos do paciente s\u00e3o coletados, \u00e0s vezes modificados ou expandidos, e depois reintroduzidos para tratar condi\u00e7\u00f5es espec\u00edficas.<sup>5<\/sup><\/p>","gt-synonyms":"Autoderivado, autodoado, aut\u00f3geno, aut\u00f3geno, autopara si, derivado do paciente, autofornecido","gt-citation":"[1] Snowden JA, Sharrack B, Akil M, Kiely DG, Lobo A, Kazmi M, Muraro PA, Lindsay JO. Autologous haematopoietic stem cell transplantation (aHSCT) for severe resistant autoimmune and inflammatory diseases \u2013 a guide for the generalist. Clin Med (Lond). 2018 Aug;18(4):329-334. DOI: 10.7861\/clinmedicine.18-4-329\n\n[2] Alagesan S, Griffin MD. Autologous and allogeneic mesenchymal stem cells in organ transplantation: what do we know about their safety and efficacy? Curr Opin Organ Transplant. 2014 Feb;19(1):65-72. DOI: 10.1097\/MOT.0000000000000043\n\n[3] Palumbo A, Cavallo F, Gay F, Di Raimondo F, Ben Yehuda D, Petrucci MT, Pezzatti S, Caravita T, Cerrato C, Ribakovsky E, Genuardi M, Cafro A, Marcatti M, Catalano L, Offidani M, Carella AM, Zamagni E, Patriarca F, Musto P, Evangelista A, Ciccone G, Omed\u00e9 P, Crippa C, Corradini P, Nagler A, Boccadoro M, Cavo M. Autologous transplantation and maintenance therapy in multiple myeloma. N Engl J Med. 2014 Sep 4;371(10):895-905. DOI: 10.1056\/NEJMoa1402888\n\n[4] van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, Larghero J, Schuerwegh AJ, Marijt EW, Vonk MC, Schattenberg AV, Matucci-Cerinic M, Voskuyl AE, van de Loosdrecht AA, Daikeler T, K\u00f6tter I, Schmalzing M, Martin T, Lioure B, Weiner SM, Kreuter A, Deligny C, Durand JM, Emery P, Machold KP, Sarrot-Reynauld F, Warnatz K, Adoue DF, Constans J, Tony HP, Del Papa N, Fassas A, Himsel A, Launay D, Lo Monaco A, Philippe P, Qu\u00e9r\u00e9 I, Rich \u00c9, Westhovens R, Griffiths B, Saccardi R, van den Hoogen FH, Fibbe WE, Soci\u00e9 G, Gratwohl A, Tyndall A; EBMT\/EULAR Scleroderma Study Group. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. JAMA. 2014 Jun 25;311(24):2490-8. DOI: 10.1001\/jama.2014.6368\n\n[5] Stiff PJ, Unger JM, Cook JR, Constine LS, Couban S, Stewart DA, Shea TC, Porcu P, Winter JN, Kahl BS, Miller TP, Tubbs RR, Marcellus D, Friedberg JW, Barton KP, Mills GM, LeBlanc M, Rimsza LM, Forman SJ, Fisher RI. Autologous transplantation as consolidation for aggressive non-Hodgkin's lymphoma. N Engl J Med. 2013 Oct 31;369(18):1681-90. DOI: 10.1056\/NEJMoa1301077","gt-clinical-context":"<p>Os procedimentos aut\u00f3logos s\u00e3o empregados em diversas especialidades m\u00e9dicas, com aplica\u00e7\u00f5es que variam de acordo com as c\u00e9lulas ou tecidos espec\u00edficos envolvidos e as condi\u00e7\u00f5es tratadas.<sup>1<\/sup><\/p>\n    \n    <p>Em hematologia e oncologia, o transplante aut\u00f3logo de c\u00e9lulas-tronco (ASCT) \u00e9 um tratamento bem estabelecido para v\u00e1rios c\u00e2nceres do sangue, incluindo mieloma m\u00faltiplo, linfoma de Hodgkin e linfoma n\u00e3o Hodgkin.<sup>3<\/sup> O procedimento envolve a coleta das pr\u00f3prias c\u00e9lulas-tronco hematopoi\u00e9ticas do paciente, a administra\u00e7\u00e3o de quimioterapia em altas doses para eliminar as c\u00e9lulas cancerosas (o que tamb\u00e9m danifica a medula \u00f3ssea saud\u00e1vel) e, em seguida, a reinfus\u00e3o das c\u00e9lulas-tronco previamente coletadas para reconstituir a capacidade hematopoi\u00e9tica do paciente.<sup>5<\/sup> Essa abordagem permite um tratamento oncol\u00f3gico mais intensivo, ao mesmo tempo que atenua o risco de supress\u00e3o prolongada da medula \u00f3ssea.<\/p>\n    \n    <p>Os tratamentos aut\u00f3logos tamb\u00e9m mostraram resultados promissores em doen\u00e7as autoimunes. Em casos graves de esclerose m\u00faltipla, esclerose sist\u00eamica e doen\u00e7a de Crohn resistentes \u00e0s terapias convencionais, o transplante aut\u00f3logo de c\u00e9lulas-tronco hematopoi\u00e9ticas pode ser considerado.<sup>1<\/sup> O procedimento visa \"reiniciar\" o sistema imunol\u00f3gico por meio da regenera\u00e7\u00e3o e rediversifica\u00e7\u00e3o dos repert\u00f3rios de c\u00e9lulas T e B e do aumento da atividade das c\u00e9lulas T reguladoras, podendo induzir remiss\u00f5es cl\u00ednicas sustentadas.<sup>1,4<\/sup><\/p>\n    \n    <p>Na medicina regenerativa e na engenharia de tecidos, as c\u00e9lulas-tronco mesenquimais (MSCs) aut\u00f3logas est\u00e3o sendo investigadas para diversas aplica\u00e7\u00f5es, incluindo o transplante de \u00f3rg\u00e3os.<sup>2<\/sup> Modelos animais indicam que as MSCs aut\u00f3logas podem ser eficazes na preven\u00e7\u00e3o ou no tratamento da inflama\u00e7\u00e3o precoce do enxerto e na redu\u00e7\u00e3o do risco de rejei\u00e7\u00e3o aguda \u2014 observa\u00e7\u00f5es respaldadas por ensaios cl\u00ednicos randomizados controlados em transplante renal com doador vivo.<sup>2<\/sup><\/p>\n    \n    <p>A sele\u00e7\u00e3o de pacientes para procedimentos aut\u00f3logos requer considera\u00e7\u00e3o cuidadosa de v\u00e1rios fatores, incluindo o estado geral de sa\u00fade do paciente, a capacidade de coletar quantidades suficientes de c\u00e9lulas ou tecidos vi\u00e1veis e a aus\u00eancia de contraindica\u00e7\u00f5es ao procedimento espec\u00edfico.<sup>1<\/sup> A decis\u00e3o cl\u00ednica de optar por tratamentos aut\u00f3logos frequentemente envolve ponderar os potenciais benef\u00edcios em rela\u00e7\u00e3o aos riscos, considerar terapias alternativas e levar em conta as prefer\u00eancias do paciente e aspectos de qualidade de vida.<\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":236},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium 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