{"id":12740,"date":"2025-07-22T08:26:38","date_gmt":"2025-07-22T12:26:38","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/antiandrogen\/"},"modified":"2025-07-22T08:26:38","modified_gmt":"2025-07-22T12:26:38","slug":"antiandrogenio","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","title":{"rendered":"Antiandrog\u00eanio"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[114],"glossary-product":[],"class_list":["post-12740","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-agents"],"acf":{"gt-definition":"<p>Os antiandrog\u00eanios s\u00e3o medicamentos que agem ligando-se aos receptores androg\u00eanicos intracelulares, prevenindo os efeitos dos andr\u00f3genos end\u00f3genos nos tecidos alvo, como test\u00edculos, fol\u00edculos capilares, hipot\u00e1lamo, hip\u00f3fise, ov\u00e1rios e pr\u00f3stata.<sup>1<\/sup> Esses medicamentos antagonizam a a\u00e7\u00e3o dos andr\u00f3genos, proibindo a liga\u00e7\u00e3o do andr\u00f3geno ao receptor andr\u00f3geno (AR), bloqueando assim o sinal andr\u00f3geno ao inibir a energia nuclear. transloca\u00e7\u00e3o.<sup>2<\/sup> Os antiandrog\u00eanios s\u00e3o classificados em ester\u00f3ides (como o acetato de ciproterona) e n\u00e3o ester\u00f3ides (incluindo flutamida, nilutamida, bicalutamida, enzalutamida, apalutamida e darolutamida).<sup>3<\/sup> Os antiandrog\u00eanios de nova gera\u00e7\u00e3o (enzalutamida, apalutamida, darolutamida) t\u00eam maior afinidade com o AR, que otimiza o efeito de bloqueio androg\u00eanico.<sup>4<\/sup> Os antiandrog\u00eanios s\u00e3o usados principalmente no tratamento do c\u00e2ncer de pr\u00f3stata, mas tamb\u00e9m s\u00e3o empregados em outras condi\u00e7\u00f5es onde a redu\u00e7\u00e3o dos efeitos androg\u00eanicos \u00e9 ben\u00e9fica.<sup>5<\/sup><\/p>\n<p>Os antiandrog\u00eanios s\u00e3o medicamentos que bloqueiam a a\u00e7\u00e3o dos horm\u00f4nios andr\u00f3genos (testosterona e di-hidrotestosterona) nos tecidos-alvo. Na urologia, s\u00e3o utilizados principalmente no tratamento do c\u00e2ncer de pr\u00f3stata avan\u00e7ado, como parte da terapia de priva\u00e7\u00e3o androg\u00eanica (TDA), e em alguns casos de hiperplasia prost\u00e1tica benigna.<\/p>","gt-synonyms":"Antagonistas dos receptores de andr\u00f3genos, bloqueadores dos receptores de andr\u00f3genos, bloqueadores de testosterona, inibidores de AR, antagonistas de andr\u00f3genos","gt-citation":"[1] Lanz C, Bennamoun M, Macek P, Cathelineau X, Sanchez-Salas R. The importance of antiandrogen in prostate cancer treatment. Ann Transl Med. 2019;7(Suppl 8):S362. DOI: 10.21037\/atm.2019.09.53\n\n[2] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. Updated October 4, 2024. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\n\n[3] LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2014. Antiandrogens. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548491\/\n\n[4] Gao W, Mahto M. Commercial Antiandrogens. In: Understanding Cancer, 2016. https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/antiandrogen\n\n[5] American Cancer Society. Hormone Therapy for Prostate Cancer. Updated November 22, 2023. https:\/\/www.cancer.org\/cancer\/types\/prostate-cancer\/treating\/hormone-therapy.html","gt-clinical-context":"<p>Os antiandrog\u00eanios s\u00e3o usados principalmente no tratamento do c\u00e2ncer de pr\u00f3stata, onde desempenham um papel importante tanto nas doen\u00e7as sens\u00edveis quanto nas resistentes \u00e0 castra\u00e7\u00e3o.<sup>1<\/sup> Desde a descoberta dos receptores de andr\u00f3genos no final da d\u00e9cada de 1960, entende-se que sua ativa\u00e7\u00e3o induz a transloca\u00e7\u00e3o do citoplasma para o n\u00facleo, levando \u00e0 express\u00e3o de genes de prolifera\u00e7\u00e3o.<sup>2<\/sup><\/p>\n \n <p>No tratamento do c\u00e2ncer de pr\u00f3stata, os antiandrog\u00eanios s\u00e3o frequentemente usados em combina\u00e7\u00e3o com a terapia de priva\u00e7\u00e3o androg\u00eanica (ADT) para obter um bloqueio androg\u00eanico completo.<sup>3<\/sup> Essa combina\u00e7\u00e3o reduz os n\u00edveis de andr\u00f3genos e evita que qualquer andr\u00f3geno restante se ligue aos receptores de andr\u00f3genos. Os antiandrog\u00eanios de primeira gera\u00e7\u00e3o (flutamida, nilutamida, bicalutamida) demonstraram benef\u00edcio cl\u00ednico ao melhorar a sobrevida global entre 3 a 8 meses e prolongar a sobrevida livre de progress\u00e3o no c\u00e2ncer de pr\u00f3stata metast\u00e1tico sens\u00edvel \u00e0 castra\u00e7\u00e3o.<sup>4<\/sup><\/p>\n \n <p>Os antiandrog\u00eanios de nova gera\u00e7\u00e3o (enzalutamida, apalutamida, darolutamida) demonstraram maior efic\u00e1cia. Por exemplo, a enzalutamida demonstrou uma melhoria da sobreviv\u00eancia global no cancro da pr\u00f3stata metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o, tanto antes como depois da quimioterapia (ensaios PREVAIL e AFFIRM), e uma melhoria da sobreviv\u00eancia livre de metast\u00e1ticos no cancro da pr\u00f3stata n\u00e3o metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o (ensaio PROSPER). teste).<sup>6<\/sup><\/p>\n \n <p>A sele\u00e7\u00e3o de pacientes para terapia antiandrog\u00eanica depende do est\u00e1gio e das caracter\u00edsticas do c\u00e2ncer de pr\u00f3stata. De acordo com as diretrizes internacionais (EAU, NCCN, AUA), os antiandrog\u00eanios s\u00e3o recomendados para pacientes com c\u00e2ncer de pr\u00f3stata n\u00e3o metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o que apresentam alto risco de met\u00e1stases, bem como para v\u00e1rios est\u00e1gios da doen\u00e7a metast\u00e1tica.<sup>7<\/sup><\/p>\n \n <p>Al\u00e9m do c\u00e2ncer de pr\u00f3stata, os antiandrog\u00eanios tamb\u00e9m s\u00e3o usados no tratamento de outras condi\u00e7\u00f5es, como hirsutismo, acne e parafilias, embora essas aplica\u00e7\u00f5es variem de acordo com o agente espec\u00edfico e \u00e0s vezes sejam off-label.<sup>8<\/sup><\/p>\n<p>De acordo com as diretrizes da EAU, os antiandrog\u00eanios podem ser esteroidais (acetato de ciproterona) ou n\u00e3o esteroidais (bicalutamida, enzalutamida, apalutamida). Os n\u00e3o esteroidais de nova gera\u00e7\u00e3o demonstraram benef\u00edcio significativo na sobrevida global do c\u00e2ncer de pr\u00f3stata metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o. Os efeitos colaterais incluem ginecomastia, fadiga e altera\u00e7\u00f5es hep\u00e1ticas.<\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":98},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Antiandrog\u00eanio: Fun\u00e7\u00e3o e Uso na Urologia | Rigicon<\/title>\n<meta name=\"description\" content=\"Entenda os antiandrog\u00eanios na urologia: bloqueio hormonal no c\u00e2ncer de pr\u00f3stata, hiperplasia prost\u00e1tica e terapia de priva\u00e7\u00e3o androg\u00eanica. Guia EAU.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antiandrog\u00eanio - Prosthetic Urology Glossary\" \/>\n<meta property=\"og:description\" content=\"Explore Rigicon\u2019s evidence-based glossary covering penile implants, AUS, ED treatments, and surgical terms in prosthetic urology.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/\" \/>\n<meta property=\"og:site_name\" content=\"Rigicon\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/rigiconurology\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rigicon.com\/wp-content\/uploads\/2025\/05\/header-d.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1440\" \/>\n\t<meta property=\"og:image:height\" content=\"718\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@rigiconurology\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/antiandrogenio\\\/\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/antiandrogenio\\\/\",\"name\":\"Antiandrog\u00eanio: Fun\u00e7\u00e3o e Uso na Urologia | Rigicon\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#website\"},\"datePublished\":\"2025-07-22T12:26:38+00:00\",\"description\":\"Entenda os antiandrog\u00eanios na urologia: bloqueio hormonal no c\u00e2ncer de pr\u00f3stata, hiperplasia prost\u00e1tica e terapia de priva\u00e7\u00e3o androg\u00eanica. Guia EAU.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/antiandrogenio\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/antiandrogenio\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/glossary-term\\\/antiandrogenio\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Glossary Terms\",\"item\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/urology-glossary\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Antiandrog\u00eanio\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#website\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\",\"name\":\"Rigicon\",\"description\":\"Innovative Urological Solutions\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#organization\"},\"alternateName\":\"Innovative Urological Solutions\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#organization\",\"name\":\"Rigicon, Inc.\",\"alternateName\":\"Innovative Urological Solutions\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.rigicon.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/cropped-Logo-Square-Kopya.jpg\",\"contentUrl\":\"https:\\\/\\\/www.rigicon.com\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/cropped-Logo-Square-Kopya.jpg\",\"width\":512,\"height\":512,\"caption\":\"Rigicon, Inc.\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rigicon.com\\\/pt-br\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/rigiconurology\\\/\",\"https:\\\/\\\/x.com\\\/rigiconurology\",\"https:\\\/\\\/www.instagram.com\\\/rigiconurology\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@Rigicon\\\/podcasts\",\"https:\\\/\\\/www.youtube.com\\\/Rigicon\",\"https:\\\/\\\/www.threads.net\\\/@rigiconurology\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/rigicon\\\/\"],\"description\":\"Rigicon is a global provider of innovative, diverse, and complete portfolio of prosthetic urology options.\",\"email\":\"operations@rigicon.com\",\"telephone\":\"+1 (888) 202-9790\",\"legalName\":\"Rigicon, Inc.\",\"vatID\":\"81-3545645\",\"taxID\":\"81-3545645\",\"duns\":\"045247683\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Antiandrog\u00eanio: Fun\u00e7\u00e3o e Uso na Urologia | Rigicon","description":"Entenda os antiandrog\u00eanios na urologia: bloqueio hormonal no c\u00e2ncer de pr\u00f3stata, hiperplasia prost\u00e1tica e terapia de priva\u00e7\u00e3o androg\u00eanica. Guia EAU.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","og_locale":"pt_BR","og_type":"article","og_title":"Antiandrog\u00eanio - Prosthetic Urology Glossary","og_description":"Explore Rigicon\u2019s evidence-based glossary covering penile implants, AUS, ED treatments, and surgical terms in prosthetic urology.","og_url":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","og_site_name":"Rigicon","article_publisher":"https:\/\/www.facebook.com\/rigiconurology\/","og_image":[{"width":1440,"height":718,"url":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2025\/05\/header-d.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_site":"@rigiconurology","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","url":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","name":"Antiandrog\u00eanio: Fun\u00e7\u00e3o e Uso na Urologia | Rigicon","isPartOf":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#website"},"datePublished":"2025-07-22T12:26:38+00:00","description":"Entenda os antiandrog\u00eanios na urologia: bloqueio hormonal no c\u00e2ncer de pr\u00f3stata, hiperplasia prost\u00e1tica e terapia de priva\u00e7\u00e3o androg\u00eanica. Guia EAU.","breadcrumb":{"@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/www.rigicon.com\/pt-br\/"},{"@type":"ListItem","position":2,"name":"Glossary Terms","item":"https:\/\/www.rigicon.com\/pt-br\/urology-glossary\/"},{"@type":"ListItem","position":3,"name":"Antiandrog\u00eanio"}]},{"@type":"WebSite","@id":"https:\/\/www.rigicon.com\/pt-br\/#website","url":"https:\/\/www.rigicon.com\/pt-br\/","name":"Rigicon","description":"Innovative Urological Solutions","publisher":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#organization"},"alternateName":"Innovative Urological Solutions","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.rigicon.com\/pt-br\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/www.rigicon.com\/pt-br\/#organization","name":"Rigicon, Inc.","alternateName":"Innovative Urological Solutions","url":"https:\/\/www.rigicon.com\/pt-br\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.rigicon.com\/pt-br\/#\/schema\/logo\/image\/","url":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2024\/07\/cropped-Logo-Square-Kopya.jpg","contentUrl":"https:\/\/www.rigicon.com\/wp-content\/uploads\/2024\/07\/cropped-Logo-Square-Kopya.jpg","width":512,"height":512,"caption":"Rigicon, Inc."},"image":{"@id":"https:\/\/www.rigicon.com\/pt-br\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/rigiconurology\/","https:\/\/x.com\/rigiconurology","https:\/\/www.instagram.com\/rigiconurology\/","https:\/\/www.youtube.com\/@Rigicon\/podcasts","https:\/\/www.youtube.com\/Rigicon","https:\/\/www.threads.net\/@rigiconurology","https:\/\/www.linkedin.com\/company\/rigicon\/"],"description":"Rigicon is a global provider of innovative, diverse, and complete portfolio of prosthetic urology options.","email":"operations@rigicon.com","telephone":"+1 (888) 202-9790","legalName":"Rigicon, Inc.","vatID":"81-3545645","taxID":"81-3545645","duns":"045247683"}]}},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-term\/12740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-term"}],"about":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/types\/glossary-term"}],"wp:attachment":[{"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/media?parent=12740"}],"wp:term":[{"taxonomy":"glossary-category","embeddable":true,"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-category?post=12740"},{"taxonomy":"glossary-product","embeddable":true,"href":"https:\/\/www.rigicon.com\/pt-br\/wp-json\/wp\/v2\/glossary-product?post=12740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}