{"id":12740,"date":"2025-07-22T08:26:38","date_gmt":"2025-07-22T12:26:38","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/antiandrogen\/"},"modified":"2026-10-06T15:38:20","modified_gmt":"2026-10-06T19:38:20","slug":"antiandrogenio","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/antiandrogenio\/","title":{"rendered":"Antiandrog\u00eanio"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[114],"glossary-product":[],"class_list":["post-12740","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-agents"],"acf":{"gt-definition":"<p>Os antiandrog\u00eanios s\u00e3o medicamentos que atuam ligando-se aos receptores androg\u00eanicos intracelulares, impedindo os efeitos dos andr\u00f3genos end\u00f3genos em tecidos-alvo como test\u00edculos, fol\u00edculos pilosos, hipot\u00e1lamo, hip\u00f3fise, ov\u00e1rios e gl\u00e2ndula prost\u00e1tica.<sup>1<\/sup> Esses f\u00e1rmacos antagonizam a a\u00e7\u00e3o dos andr\u00f3genos ao impedir a liga\u00e7\u00e3o do andr\u00f3geno ao receptor androg\u00eanico (AR), bloqueando assim o sinal androg\u00eanico pela inibi\u00e7\u00e3o da transloca\u00e7\u00e3o nuclear.<sup>2<\/sup> Os antiandrog\u00eanios s\u00e3o classificados em esteroidais (como o acetato de ciproterona) e n\u00e3o esteroidais (incluindo flutamida, nilutamida, bicalutamida, enzalutamida, apalutamida e darolutamida).<sup>3<\/sup> Os antiandrog\u00eanios de nova gera\u00e7\u00e3o (enzalutamida, apalutamida, darolutamida) t\u00eam maior afinidade pelo AR, o que otimiza o efeito de bloqueio androg\u00eanico.<sup>4<\/sup> Os antiandrog\u00eanios s\u00e3o usados principalmente no tratamento do c\u00e2ncer de pr\u00f3stata, mas tamb\u00e9m s\u00e3o empregados em outras condi\u00e7\u00f5es nas quais a redu\u00e7\u00e3o dos efeitos androg\u00eanicos \u00e9 ben\u00e9fica.<sup>5<\/sup><\/p>","gt-synonyms":"Antagonistas dos receptores de andr\u00f3genos, bloqueadores dos receptores de andr\u00f3genos, bloqueadores de testosterona, inibidores de AR, antagonistas de andr\u00f3genos","gt-citation":"[1] Lanz C, Bennamoun M, Macek P, Cathelineau X, Sanchez-Salas R. The importance of antiandrogen in prostate cancer treatment. Ann Transl Med. 2019;7(Suppl 8):S362. DOI: 10.21037\/atm.2019.09.53\n\n[2] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. Updated October 4, 2024. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\n\n[3] LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2014. Antiandrogens. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548491\/\n\n[4] Gao W, Mahto M. Commercial Antiandrogens. In: Understanding Cancer, 2016. https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/antiandrogen\n\n[5] American Cancer Society. Hormone Therapy for Prostate Cancer. Updated November 22, 2023. https:\/\/www.cancer.org\/cancer\/types\/prostate-cancer\/treating\/hormone-therapy.html","gt-clinical-context":"<p>Os antiandrog\u00eanios s\u00e3o usados principalmente no tratamento do c\u00e2ncer de pr\u00f3stata, no qual desempenham um papel importante tanto na doen\u00e7a sens\u00edvel \u00e0 castra\u00e7\u00e3o quanto na resistente \u00e0 castra\u00e7\u00e3o.<sup>1<\/sup> Desde a descoberta dos receptores androg\u00eanicos no final da d\u00e9cada de 1960, sabe-se que sua ativa\u00e7\u00e3o induz sua transloca\u00e7\u00e3o do citoplasma para o n\u00facleo, levando \u00e0 express\u00e3o de genes de prolifera\u00e7\u00e3o.<sup>2<\/sup><\/p>\n    \n    <p>No tratamento do c\u00e2ncer de pr\u00f3stata, os antiandrog\u00eanios s\u00e3o frequentemente usados em combina\u00e7\u00e3o com a terapia de priva\u00e7\u00e3o androg\u00eanica (ADT) para obter um bloqueio androg\u00eanico completo.<sup>3<\/sup> Essa combina\u00e7\u00e3o reduz os n\u00edveis de andr\u00f3genos e impede que qualquer andr\u00f3geno remanescente se ligue aos receptores androg\u00eanicos. Quando combinados com a terapia de priva\u00e7\u00e3o androg\u00eanica, os antiandrog\u00eanios de primeira gera\u00e7\u00e3o flutamida e nilutamida, segundo relatos, melhoraram a sobrevida global em 3 a 8 meses e prolongaram a sobrevida livre de progress\u00e3o no c\u00e2ncer de pr\u00f3stata metast\u00e1tico sens\u00edvel \u00e0 castra\u00e7\u00e3o, enquanto a bicalutamida mostrou um benef\u00edcio mais modesto.<sup>4<\/sup><\/p>\n    \n    <p>Os antiandrog\u00eanios de nova gera\u00e7\u00e3o (enzalutamida, apalutamida, darolutamida) demonstraram maior efic\u00e1cia. Por exemplo, a enzalutamida mostrou melhora da sobrevida global no c\u00e2ncer de pr\u00f3stata metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o, tanto antes quanto ap\u00f3s a quimioterapia (estudos PREVAIL e AFFIRM), e melhora da sobrevida livre de met\u00e1stases no c\u00e2ncer de pr\u00f3stata n\u00e3o metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o (estudo PROSPER).<sup>5<\/sup> Da mesma forma, a apalutamida demonstrou melhora da sobrevida livre de met\u00e1stases em homens com c\u00e2ncer de pr\u00f3stata n\u00e3o metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o com alto risco de desenvolver met\u00e1stases (estudo SPARTAN).<sup>6<\/sup><\/p>\n    \n    <p>A sele\u00e7\u00e3o de pacientes para a terapia antiandrog\u00eanica depende do est\u00e1gio e das caracter\u00edsticas do c\u00e2ncer de pr\u00f3stata. De acordo com as diretrizes internacionais (EAU, NCCN, AUA), os antiandrog\u00eanios s\u00e3o recomendados para pacientes com c\u00e2ncer de pr\u00f3stata n\u00e3o metast\u00e1tico resistente \u00e0 castra\u00e7\u00e3o com alto risco de met\u00e1stases, bem como para v\u00e1rios est\u00e1gios da doen\u00e7a metast\u00e1tica.<sup>7<\/sup><\/p>\n    \n    <p>Al\u00e9m do c\u00e2ncer de pr\u00f3stata, os antiandrog\u00eanios tamb\u00e9m s\u00e3o usados no tratamento de outras condi\u00e7\u00f5es, como hirsutismo, acne e parafilias, embora essas aplica\u00e7\u00f5es variem conforme o agente espec\u00edfico e \u00e0s vezes sejam off-label.<sup>8<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":164},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Antiandrog\u00eanio: Fun\u00e7\u00e3o e Uso na Urologia | Rigicon<\/title>\n<meta name=\"description\" content=\"Entenda os antiandrog\u00eanios na urologia: bloqueio hormonal no c\u00e2ncer de pr\u00f3stata, hiperplasia prost\u00e1tica e terapia de priva\u00e7\u00e3o androg\u00eanica. 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