{"id":12702,"date":"2025-07-17T03:31:33","date_gmt":"2025-07-17T07:31:33","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/bladder-instillation\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"instilacao-vesical","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/instilacao-vesical\/","title":{"rendered":"Instila\u00e7\u00e3o Vesical"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[],"glossary-product":[108,107],"class_list":["post-12702","glossary-term","type-glossary-term","status-publish","hentry","glossary-product-conticlassic-aus","glossary-product-contireflex-enhanced-aus"],"acf":{"gt-definition":"<p>A instila\u00e7\u00e3o vesical \u00e9 um procedimento terap\u00eautico que consiste em introduzir medica\u00e7\u00e3o diretamente na bexiga por meio de um cateter, permitindo que a solu\u00e7\u00e3o permane\u00e7a no local por um per\u00edodo determinado antes de ser drenada.<sup>1<\/sup> Esse tratamento leva a medica\u00e7\u00e3o diretamente ao revestimento da bexiga, evitando a circula\u00e7\u00e3o sist\u00eamica e atingindo o tecido afetado.<sup>2<\/sup> O procedimento \u00e9 usado principalmente para tratar diversas condi\u00e7\u00f5es da bexiga, reparando barreiras uroteliais danificadas, reduzindo a inflama\u00e7\u00e3o e aliviando sintomas como dor, urg\u00eancia e frequ\u00eancia urin\u00e1ria.<sup>3<\/sup><\/p>\n    \n    <p>Uma bexiga saud\u00e1vel possui uma barreira protetora natural, chamada camada de glicosaminoglicanos (GAG), que protege o revestimento da bexiga contra subst\u00e2ncias irritantes presentes na urina.<sup>4<\/sup> Quando essa camada est\u00e1 danificada, a urina pode entrar em contato direto com o revestimento da bexiga, causando inflama\u00e7\u00e3o e sintomas. A instila\u00e7\u00e3o vesical atua reduzindo a inflama\u00e7\u00e3o e o desconforto dentro da bexiga, ajudando a aliviar esses sintomas e, potencialmente, a restaurar o revestimento protetor.<sup>5<\/sup><\/p>","gt-synonyms":"Lavagem da bexiga, banho vesical, terapia intravesical, tratamento intravesical, instila\u00e7\u00e3o intravesical, instila\u00e7\u00e3o vesical","gt-citation":"[1] Digesu GA, Tailor V, Bhide AA, Khullar V. The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS? Int Urogynecol J. 2020 May;31(7):1387-1392. DOI: 10.1007\/s00192-020-04303-7\n\n[2] University Hospital Southampton NHS Foundation Trust. Bladder instillation - patient information. 2019. https:\/\/www.uhs.nhs.uk\/Media\/UHS-website-2019\/Patientinformation\/Womenshealth\/Bladder-instillation-1334-PIL.pdf\n\n[3] UC Irvine Department of Urology. Bladder Instillations. 2023. https:\/\/uciurology.com\/general-urology\/bladder-instillations\/\n\n[4] Interstitial Cystitis Association. Bladder Instillations. 2022. https:\/\/www.ichelp.org\/understanding-ic\/medical-treatments\/bladder-instillations\/\n\n[5] Hanno PM, Erickson D, Moldwin R, Faraday MM. Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment. J Urol. 2015;193(5):1545-1553. DOI: 10.1016\/j.juro.2015.01.086","gt-clinical-context":"<p>A instila\u00e7\u00e3o vesical tem indica\u00e7\u00e3o cl\u00ednica em diversas condi\u00e7\u00f5es, incluindo cistite intersticial\/s\u00edndrome da bexiga dolorosa (CI\/SBD), infec\u00e7\u00f5es urin\u00e1rias recorrentes, ac\u00famulo de sedimentos na urina, cateteres obstru\u00eddos e capacidade vesical limitada que causa mic\u00e7\u00f5es frequentes.<sup>1,3<\/sup><\/p>\n\n    <p>As diretrizes cl\u00ednicas da American Urological Association recomendam as instila\u00e7\u00f5es vesicais como op\u00e7\u00e3o de tratamento quando abordagens mais conservadoras, como modifica\u00e7\u00e3o da dieta, controle do estresse e produtos de venda livre, s\u00e3o insuficientes para controlar os sintomas.<sup>4,5<\/sup><\/p>\n\n    <h3>Os crit\u00e9rios de sele\u00e7\u00e3o de pacientes normalmente incluem aqueles com:<\/h3>\n    <ul>\n        <li>Condi\u00e7\u00f5es inflamat\u00f3rias vesicais cr\u00f4nicas, como a cistite intersticial<\/li>\n        <li>Bexiga dolorosa ou sintomas do tipo cistite<\/li>\n        <li>Frequ\u00eancia e urg\u00eancia urin\u00e1rias que n\u00e3o responderam a medicamentos orais<\/li>\n        <li>Infec\u00e7\u00f5es urin\u00e1rias recorrentes<\/li>\n        <li>Revestimento vesical danificado (camada de GAG)<sup>3,4<\/sup><\/li>\n    <\/ul>\n\n    <h3>O procedimento envolve:<\/h3>\n    <ol>\n        <li>Medir previamente a solu\u00e7\u00e3o do medicamento<\/li>\n        <li>Introduzir um cateter pela uretra at\u00e9 a bexiga<\/li>\n        <li>Instilar a solu\u00e7\u00e3o na bexiga<\/li>\n        <li>Deixar a solu\u00e7\u00e3o no local por aproximadamente 15 minutos (o tempo varia conforme o medicamento)<\/li>\n        <li>Drenar a solu\u00e7\u00e3o pelo cateter<sup>1,3<\/sup><\/li>\n    <\/ol>\n\n    <p>Os protocolos de tratamento normalmente envolvem instila\u00e7\u00f5es semanais por 6-8 semanas, seguidas de tratamentos de manuten\u00e7\u00e3o a cada poucas semanas ou meses, conforme a resposta dos sintomas.<sup>3,5<\/sup> Diversos tipos de solu\u00e7\u00f5es podem ser utilizados, incluindo:<\/p>\n\n    <ul>\n        <li><strong>Dimetilsulf\u00f3xido (DMSO, nome comercial RIMSO-50):<\/strong> A \u00fanica instila\u00e7\u00e3o vesical aprovada pela FDA especificamente para CI\/SBD, aprovada em 1978. Atua reduzindo a irrita\u00e7\u00e3o vesical, relaxando os m\u00fasculos da bexiga e da pelve, aliviando a dor pela deple\u00e7\u00e3o dos n\u00edveis de subst\u00e2ncia P e aumentando a capacidade vesical ao prevenir a forma\u00e7\u00e3o de tecido cicatricial.<sup>4<\/sup><\/li>\n        <li><strong>Heparina:<\/strong> Ajuda a reparar danos ao revestimento mucoso da bexiga e pode reduzir as taxas de recidiva da CI.<sup>3<\/sup><\/li>\n        <li><strong>Hialuronato de s\u00f3dio (Hyacyst):<\/strong> Cont\u00e9m hialuronato de s\u00f3dio, que ajuda a restaurar a camada de GAG.<sup>4<\/sup><\/li>\n        <li><strong>Mistura de resgate\/coquet\u00e9is:<\/strong> Combina\u00e7\u00f5es de medicamentos como heparina, lignoca\u00edna (lidoca\u00edna) e bicarbonato de s\u00f3dio.<sup>2,4<\/sup><\/li>\n    <\/ul>\n\n    <p>Os resultados esperados incluem melhora dos sintomas em 3-4 semanas ap\u00f3s o in\u00edcio do tratamento, com potencial manejo a longo prazo de condi\u00e7\u00f5es cr\u00f4nicas por meio de tratamentos de manuten\u00e7\u00e3o.<sup>3<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":152},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Instila\u00e7\u00e3o Vesical: Tratamento Intravesical | Rigicon<\/title>\n<meta name=\"description\" content=\"Saiba sobre instila\u00e7\u00e3o vesical, administra\u00e7\u00e3o direta de medicamentos na bexiga. 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