{"id":12538,"date":"2025-06-11T07:53:50","date_gmt":"2025-06-11T11:53:50","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/androgen-deprivation-therapy-adt\/"},"modified":"2026-10-06T12:50:55","modified_gmt":"2026-10-06T16:50:55","slug":"terapia-de-deprivacao-androgenica-tda","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/terapia-de-deprivacao-androgenica-tda\/","title":{"rendered":"Terapia de Depriva\u00e7\u00e3o Androg\u00eanica (TDA)"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[137],"glossary-product":[108,107,104,105],"class_list":["post-12538","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-hormone-therapy","glossary-product-conticlassic-aus","glossary-product-contireflex-enhanced-aus","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"A terapia de priva\u00e7\u00e3o androg\u00eanica (TPA) \u00e9 um tratamento fundamental para o c\u00e2ncer de pr\u00f3stata, particularmente em est\u00e1gios avan\u00e7ados. Ela atua reduzindo os n\u00edveis de andr\u00f3genos (horm\u00f4nios masculinos, como a testosterona) no corpo ou impedindo que esses horm\u00f4nios cheguem \u00e0s c\u00e9lulas cancerosas.\u00b9 Os andr\u00f3genos estimulam o crescimento das c\u00e9lulas do c\u00e2ncer de pr\u00f3stata; portanto, reduzir seus n\u00edveis ou bloquear sua a\u00e7\u00e3o pode retardar o crescimento tumoral, reduzir os tumores e aliviar os sintomas.\u00b9 A TPA pode ser obtida por meios cir\u00fargicos (orquiectomia, remo\u00e7\u00e3o dos test\u00edculos) ou, mais comumente, por medicamentos como agonistas do LHRH (horm\u00f4nio liberador do horm\u00f4nio luteinizante), antagonistas do LHRH ou antiandrog\u00eanicos.\u00b9 Os agonistas e antagonistas do LHRH atuam interrompendo a via de sinaliza\u00e7\u00e3o que leva \u00e0 produ\u00e7\u00e3o de testosterona nos test\u00edculos, alcan\u00e7ando efetivamente a castra\u00e7\u00e3o medicamentosa.\u00b9 Os antiandrog\u00eanicos, por outro lado, bloqueiam os receptores de andr\u00f3genos nas c\u00e9lulas cancerosas, impedindo que a testosterona se ligue a eles e exer\u00e7a seus efeitos promotores de crescimento.\u00b9 Alguns agentes mais recentes, conhecidos como inibidores da s\u00edntese de andr\u00f3genos, podem bloquear a produ\u00e7\u00e3o de andr\u00f3genos em todo o corpo, inclusive nas gl\u00e2ndulas adrenais e nas pr\u00f3prias c\u00e9lulas cancerosas.\u00b9","gt-synonyms":"Terapia hormonal para c\u00e2ncer de pr\u00f3stata, Terapia de supress\u00e3o androg\u00eanica, Castra\u00e7\u00e3o m\u00e9dica, Castra\u00e7\u00e3o cir\u00fargica (se orquiectomia), Bloqueio androg\u00eanico combinado (CAB) (quando usado com antiandrog\u00eanios)","gt-citation":"[1] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. National Institutes of Health. Updated October 4, 2024. Accessed May 14, 2025. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\r\n\r\n[2] Singh M, Agarwal V, Pancham P, et al. A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer\u2019s Disease Risk in Older Men with Prostate Cancer. Degener Neurol Neuromuscul Dis. 2024;14:33-46. Published 2024 May 17. doi:10.2147\/DNND.S445130","gt-clinical-context":"A TPA \u00e9 empregada em diversos cen\u00e1rios cl\u00ednicos no manejo do c\u00e2ncer de pr\u00f3stata.\u00b9 \u00c9 um tratamento padr\u00e3o para o c\u00e2ncer de pr\u00f3stata metast\u00e1tico, em que a doen\u00e7a se disseminou para outras partes do corpo.\u00b9 Tamb\u00e9m \u00e9 usada no c\u00e2ncer de pr\u00f3stata localmente avan\u00e7ado, frequentemente em conjunto com a radioterapia, para melhorar a efic\u00e1cia do tratamento.\u00b9 Em homens com c\u00e2ncer de pr\u00f3stata recorrente ap\u00f3s tratamentos iniciais como cirurgia ou radioterapia, a TPA pode ser usada para controlar a doen\u00e7a, especialmente se a recorr\u00eancia for sintom\u00e1tica ou se houver evid\u00eancia de n\u00edveis crescentes de PSA (ant\u00edgeno prost\u00e1tico espec\u00edfico) indicando progress\u00e3o da doen\u00e7a.\u00b9 A sele\u00e7\u00e3o de pacientes para a TPA considera fatores como o est\u00e1gio e o grau do c\u00e2ncer, o estado geral de sa\u00fade do paciente, os poss\u00edveis efeitos colaterais e as prefer\u00eancias do paciente.\u00b9 Os resultados esperados incluem redu\u00e7\u00e3o dos n\u00edveis de PSA, redu\u00e7\u00e3o dos tumores, al\u00edvio dos sintomas relacionados ao c\u00e2ncer (como dor \u00f3ssea) e, em muitos casos, prolongamento da sobrevida.\u00b9 No entanto, a TPA est\u00e1 associada a uma s\u00e9rie de efeitos colaterais, incluindo ondas de calor, perda da libido, disfun\u00e7\u00e3o er\u00e9til, fadiga e poss\u00edveis efeitos a longo prazo, como perda de densidade \u00f3ssea e altera\u00e7\u00f5es metab\u00f3licas, que precisam ser manejados.\u00b9","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":false,"gt-view-count":176},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Terapia de Depriva\u00e7\u00e3o Androg\u00eanica (TDA): C\u00e2ncer de Pr\u00f3stata | Rigicon<\/title>\n<meta name=\"description\" content=\"Guia sobre TDA para c\u00e2ncer de pr\u00f3stata: agonistas e antagonistas GnRH, castra\u00e7\u00e3o cir\u00fargica, efeitos colaterais e monitoramento. 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