{"id":12481,"date":"2025-05-21T10:23:50","date_gmt":"2025-05-21T14:23:50","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/antibiotic-impregnation\/"},"modified":"2026-10-07T01:28:59","modified_gmt":"2026-10-07T05:28:59","slug":"impregnacao-com-antibiotico","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/impregnacao-com-antibiotico\/","title":{"rendered":"Impregna\u00e7\u00e3o com Antibi\u00f3tico"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[118],"glossary-product":[104],"class_list":["post-12481","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-medical-device-coatings","glossary-product-infla10-pulse-ipp-series"],"acf":{"gt-definition":"<p>A impregna\u00e7\u00e3o com antibi\u00f3tico \u00e9 a incorpora\u00e7\u00e3o de antibi\u00f3ticos \u00e0 superf\u00edcie de um dispositivo implantado, de modo que eles sejam liberados a partir dos componentes do dispositivo e reduzam a incid\u00eancia de infec\u00e7\u00e3o do dispositivo.<sup>1<\/sup> Na cirurgia de pr\u00f3tese peniana, s\u00e3o utilizadas duas abordagens retardadoras de infec\u00e7\u00e3o: uma combina\u00e7\u00e3o de minociclina e rifampicina aplicada como revestimento no dispositivo durante a fabrica\u00e7\u00e3o e um revestimento hidrof\u00edlico que absorve antibi\u00f3ticos quando o dispositivo \u00e9 submerso em uma solu\u00e7\u00e3o antibi\u00f3tica antes da implanta\u00e7\u00e3o.<sup>2<\/sup> A minociclina e a rifampicina foram combinadas porque essa associa\u00e7\u00e3o \u00e9 altamente eficaz contra Staphylococcus, a causa mais prevalente de infec\u00e7\u00e3o de dispositivos.<sup>3<\/sup> Os revestimentos retardadores de infec\u00e7\u00e3o eliminam bact\u00e9rias contaminantes e impedem a forma\u00e7\u00e3o de biofilmes nos dispositivos implantados,<sup>2<\/sup> e, ap\u00f3s a implanta\u00e7\u00e3o, o revestimento antibacteriano continua sendo liberado do dispositivo por cerca de duas semanas.<sup>3<\/sup> De acordo com as Diretrizes da EAU, uma t\u00e9cnica cir\u00fargica cuidadosa com profilaxia adequada reduz a infec\u00e7\u00e3o para 2-3% ap\u00f3s a implanta\u00e7\u00e3o prim\u00e1ria em pacientes de baixo risco em centros de alto volume, e a taxa pode ser reduzida ainda mais para 1-2% com a implanta\u00e7\u00e3o de uma pr\u00f3tese impregnada com antibi\u00f3tico ou com revestimento hidrof\u00edlico.<sup>4<\/sup><\/p>","gt-synonyms":"Revestido com antibi\u00f3tico, eluidor de antibi\u00f3tico, carregado com antibi\u00f3tico, administra\u00e7\u00e3o local de antibi\u00f3tico, esferas de antibi\u00f3tico, impregna\u00e7\u00e3o antimicrobiana.","gt-citation":"[1] Mandava SH, Serefoglu EC, Freier MT, Wilson SK, Hellstrom WJ. Infection retardant coated inflatable penile prostheses decrease the incidence of infection: a systematic review and meta-analysis. J Urol. 2012;188(5):1855-60. doi:10.1016\/j.juro.2012.07.022. PMID: 22999690.\n\n[2] Swanton AR, Munarriz RM, Gross MS. Updates in penile prosthesis infections. Asian J Androl. 2020;22(1):28-33. doi:10.4103\/aja.aja_84_19. PMID: 31489848.\n\n[3] Patel J, Zakkar B, Polchert M, Tannenbaum J, Dick B, Raheem O. Recent technological development of penile prosthesis: a literature review. Transl Androl Urol. 2024;13(1):165-184. doi:10.21037\/tau-22-741. PMID: 38404551.\n\n[4] Salonia A, Boeri L, Capogrosso P, et al. EAU Guidelines on Sexual and Reproductive Health. Edn. presented at the EAU Annual Congress, Madrid 2025. EAU Guidelines Office, Arnhem, The Netherlands. ISBN 978-94-92671-29-5.\n\n[5] Carson CC 3rd, Mulcahy JJ, Harsch MR. Long-term infection outcomes after original antibiotic impregnated inflatable penile prosthesis implants: up to 7.7 years of followup. J Urol. 2011;185(2):614-8. doi:10.1016\/j.juro.2010.09.094. PMID: 21168870.\n\n[6] Im BH, Giordano A, Shah S, et al. Minocycline-rifampin-impregnated penile prosthesis surfaces retain antimicrobial activity following irrigation with 0.05% chlorhexidine gluconate and antibiotic solutions. J Sex Med. 2024;21(9):823-826. doi:10.1093\/jsxmed\/qdae093. PMID: 39079058.\n\n[7] Lokeshwar SD, Bitran J, Madhusoodanan V, Kava B, Ramasamy R. A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation. Curr Urol Rep. 2019;20(2):11. doi:10.1007\/s11934-019-0874-8. PMID: 30701340.\n\n[8] Wilson SK, Zumbe J, Henry GD, Salem EA, Delk JR, Cleves MA. Infection reduction using antibiotic-coated inflatable penile prosthesis. Urology. 2007;70(2):337-40. doi:10.1016\/j.urology.2007.03.058. PMID: 17826502.\n\n[9] Matthew-Onabanjo AN, Matthew AN, Famati E, Nguyen V, Rogers MJ. Perioperative infection prevention during inflatable penile prosthesis surgery: a narrative review. Transl Androl Urol. 2024;13(8):1628-1640. doi:10.21037\/tau-23-497. PMID: 39280674.","gt-clinical-context":"<p>Uma metan\u00e1lise de 14 estudos, incluindo 9.910 primeiros implantes, encontrou taxas de infec\u00e7\u00e3o de 2,32% com pr\u00f3teses infl\u00e1veis sem revestimento e de 0,89% com pr\u00f3teses revestidas, incluindo 0,63% com o revestimento de minociclina\/rifampicina, e concluiu que os revestimentos que permitem a libera\u00e7\u00e3o de antibi\u00f3ticos a partir do dispositivo reduzem a infec\u00e7\u00e3o em aproximadamente 50%.<sup>1<\/sup> Em um registro volunt\u00e1rio do fabricante, a revis\u00e3o inicial por infec\u00e7\u00e3o foi relatada em 1,1% de 35.737 homens com implantes impregnados e em 2,5% de 3.268 homens com implantes n\u00e3o impregnados, com at\u00e9 7,7 anos de seguimento.<sup>5<\/sup> In vitro, superf\u00edcies impregnadas com minociclina-rifampicina mantiveram sua atividade antimicrobiana ap\u00f3s irriga\u00e7\u00e3o com gliconato de clorexidina a 0,05% ou com solu\u00e7\u00e3o de vancomicina\/gentamicina, embora a efic\u00e1cia cl\u00ednica dessa combina\u00e7\u00e3o ainda precise ser avaliada.<sup>6<\/sup><\/p>\n<p>Com a alternativa hidrof\u00edlica, o cirurgi\u00e3o escolhe a solu\u00e7\u00e3o antibi\u00f3tica de imers\u00e3o; rifampicina\/gentamicina \u00e9 a combina\u00e7\u00e3o mais estudada, mas a mistura ideal ainda n\u00e3o foi identificada e ainda s\u00e3o necess\u00e1rios estudos controlados.<sup>7<\/sup><\/p>\n<p>A impregna\u00e7\u00e3o reduz, mas n\u00e3o elimina, a infec\u00e7\u00e3o. As Diretrizes da EAU associam as pr\u00f3teses revestidas a protocolos rigorosos que evitam a exposi\u00e7\u00e3o prolongada da ferida e minimizam o contato com a pele (t\u00e9cnica no-touch), e uma pr\u00f3tese infectada ainda requer remo\u00e7\u00e3o e tratamento antibi\u00f3tico ou resgate imediato por meio de um protocolo de lavagem.<sup>4<\/sup> Na cirurgia de revis\u00e3o, os implantes revestidos com antibi\u00f3tico n\u00e3o reduziram a infec\u00e7\u00e3o, a menos que tamb\u00e9m fosse utilizada uma lavagem antiss\u00e9ptica: a infec\u00e7\u00e3o ocorreu em 10% das revis\u00f5es sem lavagem e em 3% com lavagem.<sup>8<\/sup> Os revestimentos tamb\u00e9m podem alterar a microbiologia da infec\u00e7\u00e3o. Os microrganismos causadores de infec\u00e7\u00e3o passaram de bact\u00e9rias Gram-positivas para bact\u00e9rias Gram-negativas e fungos,<sup>7<\/sup> e os implantes revestidos foram associados a mais bact\u00e9rias at\u00edpicas e a menos infec\u00e7\u00f5es estafiloc\u00f3cicas, sugerindo uma mudan\u00e7a para pat\u00f3genos mais virulentos.<sup>2<\/sup> Em um estudo, 83% das infec\u00e7\u00f5es f\u00fangicas de implantes penianos ocorreram em homens diab\u00e9ticos ou obesos.<sup>9<\/sup><\/p>","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":false,"gt-view-count":96},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Impregna\u00e7\u00e3o com Antibi\u00f3tico: Controle de Infec\u00e7\u00e3o na Pr\u00f3tese<\/title>\n<meta name=\"description\" content=\"Como revestimentos de minociclina-rifampicina e superf\u00edcies hidrof\u00edlicas imersas em antibi\u00f3tico reduzem a infec\u00e7\u00e3o da pr\u00f3tese peniana e quais seus limites.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/impregnacao-com-antibiotico\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impregna\u00e7\u00e3o com Antibi\u00f3tico: Pr\u00f3teses Urol\u00f3gicas | Rigicon\" \/>\n<meta property=\"og:description\" content=\"Saiba sobre a impregna\u00e7\u00e3o com antibi\u00f3tico em pr\u00f3teses penianas e esf\u00edncteres urin\u00e1rios. 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