{"id":12464,"date":"2025-05-14T03:26:31","date_gmt":"2025-05-14T07:26:31","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/cavernosal-fibrosis\/"},"modified":"2026-10-06T10:51:24","modified_gmt":"2026-10-06T14:51:24","slug":"fibrose-cavernosa","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/pt-br\/glossary-term\/fibrose-cavernosa\/","title":{"rendered":"Fibrose Cavernosa"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[103,111],"glossary-product":[104,105],"class_list":["post-12464","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction","glossary-category-urological-disorders","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>A fibrose cavernosa, tamb\u00e9m conhecida como fibrose corporal, \u00e9 uma condi\u00e7\u00e3o patol\u00f3gica caracterizada pela forma\u00e7\u00e3o excessiva de tecido conjuntivo fibroso (tecido cicatricial) nos corpos cavernosos do p\u00eanis.\u00b9 Envolve o crescimento excessivo, o endurecimento e\/ou a cicatriza\u00e7\u00e3o desses tecidos er\u00e9teis, principalmente devido \u00e0 deposi\u00e7\u00e3o excessiva de componentes da matriz extracelular, em especial o col\u00e1geno.\u00b2 Esse processo leva \u00e0 perda de elasticidade e de m\u00fasculo liso no tecido cavernoso, prejudicando sua capacidade de se expandir e se encher de sangue, o que \u00e9 essencial para obter e manter uma ere\u00e7\u00e3o. Consequentemente, a fibrose cavernosa contribui de forma significativa para a disfun\u00e7\u00e3o er\u00e9til (DE).\u00b3 A condi\u00e7\u00e3o pode resultar de diversos fatores etiol\u00f3gicos, incluindo envelhecimento, diabetes mellitus, trauma no p\u00eanis, complica\u00e7\u00f5es do priapismo (ere\u00e7\u00e3o prolongada), doen\u00e7a de Peyronie, inflama\u00e7\u00e3o cr\u00f4nica ou como consequ\u00eancia de certas interven\u00e7\u00f5es m\u00e9dicas, como a explanta\u00e7\u00e3o de uma pr\u00f3tese peniana infectada ou a inje\u00e7\u00e3o intracavernosa cr\u00f4nica de medicamentos vasoativos.\u2074 O principal objetivo de compreender e identificar a fibrose cavernosa \u00e9 diagnosticar e tratar as causas subjacentes da DE e desenvolver terapias direcionadas para prevenir ou reverter as altera\u00e7\u00f5es fibr\u00f3ticas, restaurando assim a fun\u00e7\u00e3o er\u00e9til.\u2075<\/p>","gt-synonyms":"Fibrose corporal, fibrose peniana (quando se refere especificamente aos corpos cavernosos), fibrose do corpo cavernoso, CCF (fibrose cavernosa cavernosa).","gt-citation":"[1] ScienceDirect. Penile fibrosis - an overview. Available at: https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/penile-fibrosis (Accessed: May 14, 2025) .\r\n\r\n[2] ScienceDirect. Penile fibrosis - an overview. Available at: https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/penile-fibrosis (Accessed: May 14, 2025) .\r\n\r\n[3] Egydio PH, Kuehhas FE. Treatments for fibrosis of the corpora cavernosa. Arab J Urol. 2013 Jul;11(3):294-8. doi: 10.1016\/j.aju.2013.05.004. Epub 2013 Jul 9. PMID: 26558095; PMCID: PMC4443017.\r\n\r\n[4] Cho MC, Song WH, Paick J-S. Suppression of Cavernosal Fibrosis in a Rat Model. Sex Med Rev 2018;6:572\u2013582. (Cited in ScienceDirect overview)\r\n\r\n[5] Mayo Clinic. Peyronie disease - Symptoms and causes. Available at: https:\/\/www.mayoclinic.org\/diseases-conditions\/peyronies-disease\/symptoms-causes\/syc-20353468 (Accessed: May 14, 2025) .","gt-clinical-context":"<div>A fibrose cavernosa \u00e9 clinicamente relevante no contexto da disfun\u00e7\u00e3o er\u00e9til (DE) e das deformidades penianas. Ela \u00e9 frequentemente observada em pacientes com hist\u00f3rico de:<\/div>\r\n<ul>\r\n\t<li><strong>Priapismo:<\/strong>\u00a0Particularmente o priapismo de baixo fluxo refrat\u00e1rio, no qual a ere\u00e7\u00e3o prolongada leva \u00e0 hip\u00f3xia tecidual e \u00e0 consequente fibrose.\u00b3,\u2074<\/li>\r\n\t<li><strong>Trauma peniano:<\/strong>\u00a0Traumas graves no p\u00eanis podem desencadear um processo de cicatriza\u00e7\u00e3o fibr\u00f3tica.\u00b3,\u2074<\/li>\r\n\t<li><strong>Complica\u00e7\u00f5es de pr\u00f3tese peniana:<\/strong>\u00a0A explanta\u00e7\u00e3o de uma pr\u00f3tese peniana infectada \u00e9 um precursor comum de fibrose significativa dos corpos cavernosos.\u00b3<\/li>\r\n\t<li><strong>Doen\u00e7a de Peyronie:<\/strong>\u00a0Essa condi\u00e7\u00e3o \u00e9 caracterizada pela forma\u00e7\u00e3o de placas fibrosas na t\u00fanica albug\u00ednea, mas tamb\u00e9m pode envolver o tecido cavernoso subjacente.\u00b3,\u2075<\/li>\r\n\t<li><strong>Inje\u00e7\u00f5es intracavernosas cr\u00f4nicas:<\/strong>\u00a0O uso prolongado de medicamentos vasoativos injetados diretamente no p\u00eanis para o tratamento da DE pode induzir fibrose.\u00b3<\/li>\r\n\t<li><strong>Doen\u00e7as sist\u00eamicas:<\/strong>\u00a0Condi\u00e7\u00f5es como o diabetes mellitus e o envelhecimento est\u00e3o associadas a um risco aumentado de desenvolver fibrose cavernosa, devido a fatores como o estresse oxidativo e altera\u00e7\u00f5es das vias de sinaliza\u00e7\u00e3o.\u00b9,\u2074 A hipertens\u00e3o e a castra\u00e7\u00e3o tamb\u00e9m foram citadas como fatores etiol\u00f3gicos.\u00b9<\/li>\r\n\t<li><strong>P\u00f3s-prostatectomia radical:<\/strong>\u00a0A les\u00e3o dos nervos cavernosos durante a prostatectomia radical pode levar \u00e0 hip\u00f3xia cavernosa e \u00e0 consequente fibrose.\u00b9<\/li>\r\n<\/ul>\r\n<div><strong>Crit\u00e9rios de sele\u00e7\u00e3o de pacientes:<\/strong>\u00a0Pacientes que apresentam DE, especialmente se grave, progressiva ou associada a dor, curvatura ou encurtamento peniano, devem ser avaliados quanto \u00e0 fibrose cavernosa. Aqueles com os fatores de risco mencionados acima s\u00e3o particularmente suscet\u00edveis. O diagn\u00f3stico pode envolver a anamnese, o exame f\u00edsico e exames de imagem, como a ultrassonografia peniana com Doppler ou a resson\u00e2ncia magn\u00e9tica, para avaliar o fluxo sangu\u00edneo e as caracter\u00edsticas do tecido.<\/div>\r\n<div><strong>Procedimentos cir\u00fargicos:<\/strong>\u00a0Em casos de fibrose cavernosa grave que leva a DE sem resposta aos tratamentos conservadores, pode ser necess\u00e1ria uma interven\u00e7\u00e3o cir\u00fargica. A principal abordagem cir\u00fargica costuma ser a implanta\u00e7\u00e3o de pr\u00f3tese peniana. No entanto, a presen\u00e7a de fibrose significativa torna esse procedimento mais desafiador, podendo exigir t\u00e9cnicas especializadas, como escava\u00e7\u00e3o dos corpos cavernosos, ressec\u00e7\u00e3o do tecido cicatricial e enxerto, para criar espa\u00e7o adequado para o implante e restaurar o comprimento peniano ou corrigir deformidades.\u00b3<\/div>\r\n<div><strong>Resultados esperados:<\/strong>\u00a0O resultado esperado do tratamento da fibrose cavernosa depende da sua gravidade e da interven\u00e7\u00e3o escolhida. Os tratamentos conservadores em casos iniciais ou leves, como os inibidores da fosfodiesterase-5 (iPDE5) ou a pentoxifilina, visam interromper ou reverter o processo fibr\u00f3tico e melhorar a fun\u00e7\u00e3o er\u00e9til, embora sua efic\u00e1cia na fibrose grave j\u00e1 estabelecida seja limitada.\u00b3 Nos casos graves, a implanta\u00e7\u00e3o de pr\u00f3tese peniana pode restaurar a fun\u00e7\u00e3o sexual, mas a presen\u00e7a de fibrose pode afetar a complexidade da cirurgia, a recupera\u00e7\u00e3o e o tamanho final do p\u00eanis.\u00b3 A recupera\u00e7\u00e3o da cirurgia de pr\u00f3tese normalmente envolve um per\u00edodo de cicatriza\u00e7\u00e3o e adapta\u00e7\u00e3o, com taxas de sucesso para a realiza\u00e7\u00e3o da rela\u00e7\u00e3o sexual geralmente altas, embora possam ocorrer complica\u00e7\u00f5es como infec\u00e7\u00e3o, eros\u00e3o ou falha mec\u00e2nica.<\/div>","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":false,"gt-view-count":100},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fibrose Cavernosa: Impacto na Pr\u00f3tese Peniana | Rigicon<\/title>\n<meta name=\"description\" content=\"Entenda a fibrose cavernosa, substitui\u00e7\u00e3o do tecido er\u00e9til por tecido cicatricial. 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