{"id":32811,"date":"2026-09-04T18:00:00","date_gmt":"2026-09-04T22:00:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32811"},"modified":"2026-09-05T06:00:00","modified_gmt":"2026-09-05T10:00:00","slug":"%ec%9d%bc%ec%82%b0%ed%99%94%ec%a7%88%ec%86%8c","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/ko\/glossary-term\/%ec%9d%bc%ec%82%b0%ed%99%94%ec%a7%88%ec%86%8c\/","title":{"rendered":"\uc77c\uc0b0\ud654\uc9c8\uc18c"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32811","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>\n        \uc77c\uc0b0\ud654\uc9c8\uc18c(NO)\ub294 \ubb34\uc0c9\uc758 \uae30\uccb4\uc131 \uc2e0\ud638 \uc804\ub2ec \ubd84\uc790\ub85c, \ud2b9\ud788 \uc74c\uacbd \ubc1c\uae30 \ubc0f \ud608\uad00 \ud655\uc7a5\uc744 \ube44\ub86f\ud55c \uc218\ub9ce\uc740 \uc0dd\ub9ac\uc801 \uacfc\uc815\uc5d0\uc11c \ud575\uc2ec\uc801\uc778 \ub9e4\uac1c\uccb4 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<sup>1<\/sup> \uc774\ub294 \uc74c\uacbd \uc870\uc9c1 \ub0b4\uc5d0\uc11c \uc8fc\ub85c \uc2e0\uacbd\ud615 NOS(nNOS) \ubc0f \ub0b4\ud53c\ud615 NOS(eNOS)\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc77c\uc0b0\ud654\uc9c8\uc18c \ud569\uc131\ud6a8\uc18c(NOS)\uc5d0 \uc758\ud574 \uc544\ubbf8\ub178\uc0b0\uc778 L-\uc544\ub974\uae30\ub2cc\uc73c\ub85c\ubd80\ud130 \uccb4\ub0b4\uc5d0\uc11c \ud569\uc131\ub429\ub2c8\ub2e4.<sup>2<\/sup> NO\ub294 \uc74c\uacbd\uc5d0\uc11c \uc8fc\ub41c \ud608\uad00\uc791\uc6a9\uc131 \ube44\uc544\ub4dc\ub808\ub0a0\ub9b0\uc131 \ube44\ucf5c\ub9b0\uc131 \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\ub85c \uc791\uc6a9\ud558\uc5ec \ubc1c\uae30\uc758 \uc2dc\uc791\uacfc \uc720\uc9c0\uc5d0 \uacb0\uc815\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<sup>3<\/sup>\n    <\/p>\n<p>\n        \uc131\uc801 \uc790\uadf9\uc774 \ubc1c\uc0dd\ud558\uba74 \ud574\uba74\uccb4\uc2e0\uacbd \ub9d0\ub2e8(nNOS\ub97c \ud1b5\ud574)\uacfc \uc74c\uacbd\ud574\uba74\uccb4\uc758 \ud608\uad00 \ubc0f \ub3d9\uc591\ud608\uad00\uc744 \ub458\ub7ec\uc2fc \ub0b4\ud53c\uc138\ud3ec(eNOS\ub97c \ud1b5\ud574) \ubaa8\ub450\uc5d0\uc11c NO\uac00 \ubc29\ucd9c\ub429\ub2c8\ub2e4.<sup>4<\/sup> \ubc29\ucd9c\ub41c NO\ub294 \ud3c9\ud65c\uadfc \uc138\ud3ec\ub9c9\uc744 \uac00\ub85c\uc9c8\ub7ec \ud655\uc0b0\ub418\uc5b4 \uac00\uc6a9\uc131 \uad6c\uc544\ub2d0\ub9b4 \uace0\ub9ac\ud654\ud6a8\uc18c(sGC)\ub97c \ud65c\uc131\ud654\ud558\uba70, \uc774\ub294 \uad6c\uc544\ub178\uc2e0 \uc0bc\uc778\uc0b0(GTP)\uc774 \uc0ac\uc774\ud074\ub9ad \uad6c\uc544\ub178\uc2e0 \uc77c\uc778\uc0b0(cGMP)\uc73c\ub85c \uc804\ud658\ub418\ub294 \uacfc\uc815\uc744 \ucd09\ub9e4\ud569\ub2c8\ub2e4.<sup>5<\/sup> \uc774\ub7ec\ud55c 2\ucc28 \uc804\ub839\uc740 cGMP \uc758\uc874\uc131 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c(PKG)\ub97c \ud65c\uc131\ud654\ud558\uc5ec \uc138\ud3ec\uc9c8 \ub0b4 \uce7c\uc298 \uc218\uce58 \uac10\uc18c, \ud574\uba74\uccb4 \ud3c9\ud65c\uadfc \uc774\uc644, \uc74c\uacbd\uc73c\ub85c\uc758 \ud608\ub958 \uc99d\uac00, \uc815\ub9e5 \uc720\ucd9c \ucc28\ub2e8, \uadf8\ub9ac\uace0 \uad81\uadf9\uc801\uc73c\ub85c \uc74c\uacbd \ubc1c\uae30\ub85c \uc774\uc5b4\uc9c0\ub294 \uc77c\ub828\uc758 \ubc18\uc751\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4.<sup>6<\/sup>\n    <\/p>","gt-synonyms":"\uc0b0\ud654\uc9c8\uc18c, \uc77c\uc0b0\ud654\uc77c\uc9c8\uc18c, NO, EDRF(\ub0b4\ud53c\uc138\ud3ec \uc720\ub798 \uc774\uc644\uc778\uc790), \ub2c8\ud2b8\ub85c\uc2e4 \ub77c\ub514\uce7c, \ub0b4\ud53c \uc720\ub798 \uc77c\uc0b0\ud654\uc9c8\uc18c, \ub0b4\uc778\uc131 \uc9c8\uc0b0\uc5fc \ud608\uad00\ud655\uc7a5\uc81c, \uc625\uc18c\uc544\uc790\ub2d0","gt-citation":"[1] Burnett AL. The role of nitric oxide in erectile dysfunction: implications for medical therapy. J Clin Hypertens (Greenwich). 2006;8(12 Suppl 4):53-62. doi: 10.1111\/j.1524-6175.2006.06026.x\n\n[2] Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Pharmacol Ther. 2005;106(2):233-66. doi: 10.1016\/j.pharmthera.2004.11.011\n\n[3] Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev. 2011;63(4):811-59. doi: 10.1124\/pr.111.004515\n\n[4] MacDonald EA, Burnett AL. The role of nitric oxide in erectile function and sexual behavior. J Sex Med. 2021;18(5):872-887. doi: 10.1016\/j.jsxm.2021.02.006\n\n[5] Sullivan ME, Thompson CS, Dashwood MR, et al. Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res. 1999;43(3):658-65. doi: 10.1016\/s0008-6363(99)00135-2\n\n[6] Pereira DA, Silveira TH, Calmasini FB, Silva FH. Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease. Front Pharmacol. 2024;15:1357176. doi: 10.3389\/fphar.2024.1357176","gt-clinical-context":"<p>\n        \uc77c\uc0b0\ud654\uc9c8\uc18c\ub294 \ubc1c\uae30 \uae30\ub2a5 \ubc0f \ubc1c\uae30\ubd80\uc804\uacfc \uad00\ub828\ub41c \uc5ec\ub7ec \uc784\uc0c1 \uc0c1\ud669\uc5d0\uc11c \uc911\ucd94\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4:\n    <\/p>\n<p>\n        <strong>\ubc1c\uae30\ubd80\uc804(ED):<\/strong> \uc190\uc0c1\ub41c NO \uc0dd\uccb4\uc774\uc6a9\ub960\uc740 \ubc1c\uae30\ubd80\uc804\uc758 \uae30\uc800\uc5d0 \uc788\ub294 \uc8fc\uc694 \ubcd1\uc778 \uae30\uc804\uc785\ub2c8\ub2e4.<sup>1<\/sup> \ub0b4\ud53c \uae30\ub2a5 \uc7a5\uc560, \ub2f9\ub1e8\ubcd1, \uace0\ud608\uc555, \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d, \ub178\ud654, \ud761\uc5f0\uc744 \ud3ec\ud568\ud558\uc5ec NO \uc0dd\uc131 \ub610\ub294 \uc2e0\ud638 \uc804\ub2ec\uc744 \uc190\uc0c1\uc2dc\ud0a4\ub294 \ub2e4\uc591\ud55c \uc9c8\ud658\uc774 ED\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>2<\/sup> \ubc1c\uae30 \uae30\ub2a5\uc5d0\uc11c NO\uc758 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc774 \ubc1d\ud600\uc9c0\uba74\uc11c ED \uce58\ub8cc\uc5d0 \ud601\uc2e0\uc774 \uc77c\uc5b4\ub0ac\uc73c\uba70, cGMP\uc758 \ubd84\ud574\ub97c \uc5b5\uc81c\ud558\uc5ec NO \ub9e4\uac1c \ud6a8\uacfc\ub97c \uac15\ud654\ud558\ub294 \ud3ec\uc2a4\ud3ec\ub514\uc5d0\uc2a4\ud14c\ub77c\uc544\uc81c 5\ud615(PDE5) \uc5b5\uc81c\uc81c\uc758 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc84c\uc2b5\ub2c8\ub2e4.<sup>3<\/sup>\n    <\/p>\n<p>\n        <strong>\uc2ec\ud608\uad00 \uac74\uac15:<\/strong> \ubc1c\uae30 \uae30\ub2a5\uc5d0\uc11c\uc758 \uc5ed\ud560 \uc678\uc5d0\ub3c4, NO\ub294 \ud608\uc555\uacfc \ud608\uad00 \uae34\uc7a5\ub3c4\ub97c \uc870\uc808\ud558\ub294 \uac15\ub825\ud55c \ud608\uad00 \ud655\uc7a5\uc81c\ub85c \uc791\uc6a9\ud558\uc5ec \uc2ec\ud608\uad00 \uac74\uac15\uc5d0 \ud544\uc218\uc801\uc785\ub2c8\ub2e4.<sup>4<\/sup> \uc74c\uacbd \uc870\uc9c1\uc5d0\uc11c NO \uc0dd\uc131\uc744 \uc800\ud574\ud558\ub294 \ub3d9\uc77c\ud55c \ub0b4\ud53c \uae30\ub2a5 \uc7a5\uc560\uac00 \uc804\uc2e0 \ud608\uad00\uacc4\uc5d0\ub3c4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc73c\uba70, \uc774\ub294 ED\uac00 \uc885\uc885 \uc804\uc2e0 \ud608\uad00 \uc9c8\ud658\uc758 \uc870\uae30 \uc9c0\ud45c\uac00 \ub418\ub294 \uc774\uc720\ub97c \uc124\uba85\ud574 \uc90d\ub2c8\ub2e4.<sup>5<\/sup>\n    <\/p>\n<p>\n        <strong>\uce58\ub8cc\uc801 \uc801\uc6a9:<\/strong> NO-cGMP \uacbd\ub85c\ub294 ED\uc5d0 \ub300\ud55c \uc5ec\ub7ec \uce58\ub8cc\uc801 \uc911\uc7ac\uc758 \ud45c\uc801\uc785\ub2c8\ub2e4:\n    <\/p>\n<ul>\n<li>PDE5 \uc5b5\uc81c\uc81c(\uc608: \uc2e4\ub370\ub098\ud544, \ud0c0\ub2e4\ub77c\ud544, \ubc14\ub974\ub370\ub098\ud544)\ub294 cGMP\ub97c \ubd84\ud574\ud558\ub294 \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud558\uc5ec NO \ub9e4\uac1c \ud6a8\uacfc\ub97c \uc99d\uac15\uc2dc\ud0b5\ub2c8\ub2e4<\/li>\n<li>\uac00\uc6a9\uc131 \uad6c\uc544\ub2d0\ub9b4 \uace0\ub9ac\ud654\ud6a8\uc18c(sGC) \uc790\uadf9\uc81c \ubc0f \ud65c\uc131\uc81c\ub294 cGMP \uc0dd\uc131\uc744 \uc9c1\uc811 \uc790\uadf9\ud558\ub294 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc73c\ub85c, NO \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \uac10\uc18c\ub41c \uacbd\uc6b0\uc5d0 \ud6a8\uacfc\uc801\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4<sup>6<\/sup><\/li>\n<li>L-\uc544\ub974\uae30\ub2cc \ubcf4\ucda9\uc740 NO \ud569\uc131 \uae30\uc9c8\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4<\/li>\n<\/ul>\n<p>\n        <strong>\ud658\uc790 \uc120\ud0dd:<\/strong> NO \ud45c\uc801 \uce58\ub8cc\uc758 \ud6a8\uacfc\ub294 ED\uc758 \uadfc\ubcf8\uc801\uc778 \uc6d0\uc778\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. PDE5 \uc5b5\uc81c\uc81c\ub294 \uacbd\uc99d\uc5d0\uc11c \uc911\ub4f1\ub3c4\uc758 ED \ubc0f \uc2e0\uacbd \uacbd\ub85c\uac00 \ubcf4\uc874\ub41c \ud658\uc790\uc5d0\uc11c \uac00\uc7a5 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \uc2ec\uac01\ud55c \ud608\uad00 \uc190\uc0c1\uc73c\ub85c \uc778\ud55c \uc911\uc99d ED \ub610\ub294 \uc2e0\uacbd \uc190\uc0c1\uc744 \ub3d9\ubc18\ud55c \uadfc\uce58\uc801 \uc804\ub9bd\uc120\uc808\uc81c\uc220 \ud6c4\uc5d0\ub294 \ud6a8\uacfc\uac00 \ub5a8\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>4<\/sup> PDE5 \uc5b5\uc81c\uc81c\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \ud574\uba74\uccb4 \ub0b4 \uc8fc\uc0ac \uc694\ubc95, \uc9c4\uacf5\uc74c\uacbd\ud761\uc785\uae30 \ub610\ub294 \uc74c\uacbd\uc784\ud50c\ub780\ud2b8\uc640 \uac19\uc740 \ub300\uccb4 \uce58\ub8cc\ubc95\uc774 \ud544\uc694\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>5<\/sup>\n    <\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":true,"gt-view-count":2},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\uc77c\uc0b0\ud654\uc9c8\uc18c: \uc74c\uacbd \ubc1c\uae30 \ubc0f \ud608\uad00 \ud655\uc7a5\uc5d0\uc11c\uc758 \uc5ed\ud560<\/title>\n<meta name=\"description\" content=\"\uc77c\uc0b0\ud654\uc9c8\uc18c\ub294 \uc74c\uacbd\ud574\uba74\uccb4\uc758 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ud0a4\uace0 \ud608\ub958\ub97c \uc99d\uac00\uc2dc\ucf1c \uc74c\uacbd \ubc1c\uae30\ub97c \uc720\ub3c4\ud558\uace0 \ub9e4\uac1c\ud558\ub294 \ud575\uc2ec\uc801\uc778 \uae30\uccb4\uc131 \uc2e0\ud638 \uc804\ub2ec \ubd84\uc790\uc785\ub2c8\ub2e4. \uc774\ub294 \ub0a8\uc131 \uc131\uae30\ub2a5\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc804\uc2e0 \ud608\uad00 \uac74\uac15\uc744 \uc720\uc9c0\ud558\uace0 \uc870\uc808\ud558\ub294 \ub370 \ud544\uc218\uc801\uc778 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content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"\uc77c\uc0b0\ud654\uc9c8\uc18c: \uc74c\uacbd \ubc1c\uae30 \ubc0f \ud608\uad00 \ud655\uc7a5\uc5d0\uc11c\uc758 \uc5ed\ud560\" \/>\n<meta name=\"twitter:description\" content=\"\uc77c\uc0b0\ud654\uc9c8\uc18c\ub294 \uc74c\uacbd\ud574\uba74\uccb4\uc758 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ud0a4\uace0 \ud608\ub958\ub97c \uc99d\uac00\uc2dc\ucf1c \uc74c\uacbd \ubc1c\uae30\ub97c \uc720\ub3c4\ud558\uace0 \ub9e4\uac1c\ud558\ub294 \ud575\uc2ec\uc801\uc778 \uae30\uccb4\uc131 \uc2e0\ud638 \uc804\ub2ec \ubd84\uc790\uc785\ub2c8\ub2e4. \uc774\ub294 \ub0a8\uc131 \uc131\uae30\ub2a5\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc804\uc2e0 \ud608\uad00 \uac74\uac15\uc744 \uc720\uc9c0\ud558\uace0 \uc870\uc808\ud558\ub294 \ub370 \ud544\uc218\uc801\uc778 \uc0dd\ub9ac\uc801 \uc5ed\ud560\uc744 \uc218\ud589\ud569\ub2c8\ub2e4.\" \/>\n<meta name=\"twitter:site\" content=\"@rigiconurology\" \/>\n<script type=\"application\/ld+json\" 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