{"id":32633,"date":"2026-09-05T18:35:00","date_gmt":"2026-09-05T22:35:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32633"},"modified":"2026-10-07T01:28:59","modified_gmt":"2026-10-07T05:28:59","slug":"%ec%95%bd%eb%a6%ac%ec%97%ad%ed%95%99%ec%a0%81-%ea%b2%b0%ed%95%a9","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/ko\/glossary-term\/%ec%95%bd%eb%a6%ac%ec%97%ad%ed%95%99%ec%a0%81-%ea%b2%b0%ed%95%a9\/","title":{"rendered":"\uc57d\ub9ac\uc5ed\ud559\uc801 \uacb0\ud569"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32633","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>\uc57d\ub9ac\uc5ed\ud559\uc801 \uacb0\ud569\uc740 \ub9c9\uc804\uc704\uc640 \ubb34\uad00\ud558\uac8c \ud3c9\ud65c\uadfc \uc218\ucd95\uc744 \uc870\uc808\ud558\ub294 \uc0dd\ub9ac\ud559\uc801 \uae30\uc804\uc744 \ub9d0\ud569\ub2c8\ub2e4.<sup>1<\/sup> \ud574\uba74\uccb4 \ud3c9\ud65c\uadfc\uc5d0\uc11c\ub294 \uc791\uc6a9\uc81c\uac00 G \ub2e8\ubc31\uc9c8 \uacb0\ud569 \uc218\uc6a9\uccb4\uc5d0 \uacb0\ud569\ud568\uc73c\ub85c\uc368 \ucd09\ubc1c\ub429\ub2c8\ub2e4.<sup>2<\/sup> \uc774\ub294 \ub9c9 \ud0c8\ubd84\uadf9\uc5d0 \ub4a4\uc774\uc5b4 \uc218\ucd95 \ubc18\uc751\uc774 \uc77c\uc5b4\ub098\ub294 \uc804\uae30\uc5ed\ud559\uc801 \uacb0\ud569\uacfc \uad6c\ubcc4\ub429\ub2c8\ub2e4.<sup>2<\/sup> \ub300\ud45c\uc801\uc778 \uc608\ub294 \ud654\ud559\uc801 \uc804\ub2ec\ubb3c\uc9c8\uc778 \uc774\ub178\uc2dc\ud1a8 1,4,5-\uc0bc\uc778\uc0b0(IP3)\uc5d0 \uc758\ud55c \uadfc\uc18c\ud3ec\uccb4\ub85c\ubd80\ud130\uc758 Ca2+ \ubc29\ucd9c\ub85c, \uc774\ub294 \ud0c8\ubd84\uadf9\uc774 \uc544\ub2c8\ub77c \uc791\uc6a9\uc81c-\uc218\uc6a9\uccb4 \uc0c1\ud638\uc791\uc6a9\uc5d0 \uc758\ud574 \uc2dc\uc791\ub429\ub2c8\ub2e4.<sup>1<\/sup> \uc774 \uac1c\ub150\uc740 \uc218\ucd95 \uc7a5\uce58\uc758 Ca2+ \ubbfc\uac10\ub3c4 \ubcc0\ud654\ub3c4 \ud3ec\ud568\ud569\ub2c8\ub2e4. Ca2+ \uac10\uc791\uc740 \ubbf8\uc624\uc2e0 \ud3ec\uc2a4\ud30c\ud0c0\uc81c\uc758 \uc5b5\uc81c\uc5d0 \uae30\uc778\ud558\uba70, \uc774 \uc5b5\uc81c\ub294 \uc18c\ud615 GTP \uacb0\ud569 \ub2e8\ubc31\uc9c8 RhoA\uc640 \uadf8 \ud6a8\uacfc\uae30\uc778 Rho-\ud0a4\ub098\uc81c\uc758 \ud65c\uc131\ud654\uac00 \uc8fc\ub3c4\ud560 \uac00\ub2a5\uc131\uc774 \uac00\uc7a5 \ub192\uc740 \ubc18\uba74, \uace0\ub9ac\ud615 \ub274\ud074\ub808\uc624\ud2f0\ub4dc \ud65c\uc131\ud654 \ud0a4\ub098\uc81c\ub294 \uadfc\uc721\uc744 \ud0c8\uac10\uc791\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>1<\/sup> Ca2+ \ubbfc\uac10\ub3c4\ub294 \ubbf8\uc624\uc2e0 \uacbd\uc1c4 \ud0a4\ub098\uc81c\uc640 \ud3ec\uc2a4\ud30c\ud0c0\uc81c \ud65c\uc131 \uc0ac\uc774\uc758 \uade0\ud615\uc744 \ubc18\uc601\ud558\uba70, \ud3c9\ud65c\uadfc \uae30\ub2a5\uc744 \uacb0\uc815\ud558\ub294 \uc8fc\uc694 \uc870\uc808 \uc778\uc790\uc785\ub2c8\ub2e4.<sup>3<\/sup> \uc74c\uacbd\uc5d0\uc11c\ub294 \uc774\ub7ec\ud55c \uae30\uc804\uc774 \uc74c\uacbd\ud574\uba74\uccb4 \ud3c9\ud65c\uadfc\uc758 \uae34\uc7a5\ub3c4\ub97c \uc870\uc808\ud558\uc5ec \ube44\ubc1c\uae30(\uc774\uc644) \uc0c1\ud0dc\uc640 \ubc1c\uae30 \uc0ac\uc774\uc758 \uade0\ud615\uc744 \uc88c\uc6b0\ud569\ub2c8\ub2e4.<sup>2<\/sup><\/p>","gt-synonyms":"\ud1b5\uc0c1\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ub3d9\uc758\uc5b4 \uc5c6\uc74c.","gt-citation":"[1] Somlyo AP, Wu X, Walker LA, Somlyo AV. Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol. 1999;134:201-34. doi:10.1007\/3-540-64753-8_5. PMID: 10087910.\n\n[2] de Souza ILL, Ferreira EDS, Vasconcelos LHC, Cavalcante FA, da Silva BA. Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells. Front Pharmacol. 2022;13:895044. doi:10.3389\/fphar.2022.895044. PMID: 35865945.\n\n[3] Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003;83(4):1325-58. doi:10.1152\/physrev.00023.2003. PMID: 14506307.\n\n[4] Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev. 2011;63(4):811-59. doi:10.1124\/pr.111.004515. PMID: 21880989.\n\n[5] Salonia A, Boeri L, Capogrosso P, et al. EAU Guidelines on Sexual and Reproductive Health. Edn. presented at the EAU Annual Congress, Madrid 2025. EAU Guidelines Office, Arnhem, The Netherlands. ISBN 978-94-92671-29-5.\n\n[6] Chitaley K, Wingard CJ, Clinton Webb R, et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med. 2001;7(1):119-22. doi:10.1038\/83258. PMID: 11135626.","gt-clinical-context":"<p>\uc218\ucd95 \uc778\uc790\uc640 \uc774\uc644 \uc778\uc790 \uc0ac\uc774\uc758 \uade0\ud615\uc774 \uc74c\uacbd\ud574\uba74\uccb4 \ud3c9\ud65c\uadfc\uc758 \uc218\ucd95 \uc815\ub3c4\ub97c \uc870\uc808\ud558\uace0 \uc74c\uacbd\uc758 \uae30\ub2a5\uc801 \uc0c1\ud0dc\ub97c \uacb0\uc815\ud569\ub2c8\ub2e4. \ub178\ub974\uc544\ub4dc\ub808\ub0a0\ub9b0\uc740 \u03b11-\uc544\ub4dc\ub808\ub0a0\ub9b0 \uc218\uc6a9\uccb4\ub97c \ud1b5\ud574 \uc74c\uacbd\ud574\uba74\uccb4\uc640 \uc74c\uacbd \ud608\uad00\uc744 \ubaa8\ub450 \uc218\ucd95\uc2dc\ud0b5\ub2c8\ub2e4.<sup>4<\/sup> \uad50\uac10\uc2e0\uacbd \uc790\uadf9\uc740 \uc74c\uacbd\uc744 \ube44\ubc1c\uae30 \uc0c1\ud0dc\ub85c \uc720\uc9c0\ud558\ub294 \uc8fc\ub41c \uae30\uc804\uc785\ub2c8\ub2e4. \uc804\uae30\uc5ed\ud559\uc801 \uacb0\ud569\ub3c4 \ud574\uba74\uccb4 \ud3c9\ud65c\uadfc \uc218\ucd95\uc5d0 \uae30\uc5ec\ud558\uc9c0\ub9cc, \ube44\ubc1c\uae30 \uc0c1\ud0dc\ub294 \uc8fc\ub85c \uc57d\ub9ac\uc5ed\ud559\uc801 \uacb0\ud569\uc5d0\uc11c \ube44\ub86f\ub429\ub2c8\ub2e4. \uc791\uc6a9\uc81c\uac00 G \ub2e8\ubc31\uc9c8 \uacb0\ud569 \uc218\uc6a9\uccb4\uc5d0 \uacb0\ud569\ud558\uc5ec Gq\/11-\ud3ec\uc2a4\ud3ec\ub9ac\ud30c\uc81c C\u03b21 \uc5f0\uc1c4 \ubc18\uc751\uc744 \ud65c\uc131\ud654\ud558\uba74, \uadfc\uc18c\ud3ec\uccb4\uc5d0\uc11c Ca2+\ub97c \ubc29\ucd9c\uc2dc\ud0a4\ub294 IP3\uc640 \ub514\uc544\uc2e4\uae00\ub9ac\uc138\ub864\uc774 \uc0dd\uc131\ub429\ub2c8\ub2e4.<sup>2<\/sup> \uc5d4\ub3c4\ud154\ub9b0-1\uacfc \uc548\uc9c0\uc624\ud150\uc2e0 II \uac19\uc740 \uc218\ucd95\uc131 \uc791\uc6a9\uc81c\ub294 G12\/13 \ub2e8\ubc31\uc9c8\uc744 \ud1b5\ud574 RhoA\ub3c4 \ud65c\uc131\ud654\ud569\ub2c8\ub2e4. \uc774\uc5b4\uc11c Rho-\ud0a4\ub098\uc81c\uac00 \ubbf8\uc624\uc2e0 \uacbd\uc1c4 \ud3ec\uc2a4\ud30c\ud0c0\uc81c\uc758 \uc870\uc808 \uc18c\ub2e8\uc704\ub97c \uc778\uc0b0\ud654\ud558\uc5ec \uc774\ub97c \ubd88\ud65c\uc131\ud654\ud558\uace0 \uc218\ucd95\uc744 \uc720\uc9c0\ud558\uba70, \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc81c C\ub294 \ud3ec\uc2a4\ud30c\ud0c0\uc81c \uc5b5\uc81c\uc81c CPI-17\uc744 \uc778\uc0b0\ud654\ud568\uc73c\ub85c\uc368 \uc774 \ud6a8\uacfc\ub97c \uac15\ud654\ud569\ub2c8\ub2e4.<sup>2<\/sup><\/p>\n<p>\ubc1c\uae30\ub294 \uadf8 \ubc18\ub300 \uacfc\uc815\uc5d0 \uc758\uc874\ud569\ub2c8\ub2e4. \uc2e0\uacbd\uc131 \uc0b0\ud654\uc9c8\uc18c(NO)\ub294 \uc74c\uacbd \ud608\uad00\uacfc \uc74c\uacbd\ud574\uba74\uccb4\uc758 \uc774\uc644\uc5d0 \uac00\uc7a5 \uc911\uc694\ud55c \uc778\uc790\ub85c \uc5ec\uaca8\uc9d1\ub2c8\ub2e4.<sup>4<\/sup> NO\ub294 \uac00\uc6a9\uc131 \uad6c\uc544\ub2d0\uc0b0 \uace0\ub9ac\ud654\ud6a8\uc18c\ub97c \uc790\uadf9\ud558\uc5ec \uace0\ub9ac\ud615 \uad6c\uc544\ub178\uc2e0 \uc77c\uc778\uc0b0(cGMP)\uc744 \uc0dd\uc131\ud558\uac8c \ud558\uace0, cGMP\ub294 cGMP \uc758\uc874\uc131 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc81c\ub97c \ud65c\uc131\ud654\ud569\ub2c8\ub2e4. \uc774 \ud0a4\ub098\uc81c\ub294 K+ \ud1b5\ub85c \ud65c\uc131\ud654, \uc804\uc555 \uc758\uc874\uc131 Ca2+ \ud1b5\ub85c \uc5b5\uc81c, Ca2+\uc758 \uaca9\ub9ac \ubc0f \ubc30\ucd9c \uc99d\uac00 \ub4f1 \uc5ec\ub7ec \ubc29\uc2dd\uc73c\ub85c \uc138\ud3ec \ub0b4 Ca2+\ub97c \ub0ae\ucda5\ub2c8\ub2e4.<sup>2<\/sup> Ca2+ \ud0c8\uac10\uc791\uc5d0\ub294 cGMP \ud65c\uc131\ud654 \ud0a4\ub098\uc81c\uc640 RhoA\/Rho-\ud0a4\ub098\uc81c \uacbd\ub85c \uc0ac\uc774\uc758 \uae38\ud56d \uc791\uc6a9\ub3c4 \uad00\uc5ec\ud569\ub2c8\ub2e4.<sup>3<\/sup><\/p>\n<p>\uc774\ub7ec\ud55c \uacbd\ub85c\ub294 \ubc1c\uae30\ubd80\uc804(ED)\uc774 \uc5b4\ub5bb\uac8c \ubc1c\uc0dd\ud560 \uc218 \uc788\ub294\uc9c0, \uadf8\ub9ac\uace0 \uc57d\ubb3c\uc774 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud558\ub294\uc9c0\ub97c \uc124\uba85\ud569\ub2c8\ub2e4. \uc774 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc758 \uc5b4\ub290 \ub2e8\uacc4\uc5d0\uc11c\ub4e0 \uc870\uc808 \uc774\uc0c1\uc774 \uc0dd\uae30\uba74 \uc74c\uacbd \uae30\ub2a5\uc774 \uc190\uc0c1\ub418\uc5b4 ED\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc74c\uacbd\uc5d0\uc11c \uc8fc\ub41c \ud3ec\uc2a4\ud3ec\ub514\uc5d0\uc2a4\ud14c\ub77c\uc81c \ub3d9\ud615\uc740 cGMP\uc5d0 \ud2b9\uc774\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 PDE5\uc785\ub2c8\ub2e4. PDE5 \uc5b5\uc81c\uc81c\ub294 \uc138\ud3ec \ub0b4 cGMP\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \uc74c\uacbd\ud574\uba74\uccb4\uc758 \uc774\uc644\uc744 \ucd09\uc9c4\ud558\uc9c0\ub9cc, NO \ub18d\ub3c4\ub97c \ub192\uc774\uace0 cGMP\ub97c \uc0dd\uc131\ud558\ub824\uba74 \uc0ac\uc804 \uc131\uc801 \uc790\uadf9\uc774 \ud544\uc218\uc801\uc785\ub2c8\ub2e4.<sup>2<\/sup> \uc720\ub7fd\uc758\uc57d\ud488\uccad(European Medicines Agency)\uc740 ED \uce58\ub8cc\ub97c \uc704\ud574 \ub124 \uac00\uc9c0 \uc120\ud0dd\uc801 PDE5 \uc5b5\uc81c\uc81c\ub97c \uc2b9\uc778\ud588\uc2b5\ub2c8\ub2e4.<sup>5<\/sup> \ub7ab\ub4dc\uc5d0\uc11c Rho-\ud0a4\ub098\uc81c\uc758 \uc57d\ub9ac\ud559\uc801 \uae38\ud56d\uc740 NO\uc640 \ubb34\uad00\ud558\uac8c \uc74c\uacbd \ubc1c\uae30\ub97c \uc790\uadf9\ud588\uc73c\uba70, \uc774\ub294 ED \uce58\ub8cc\uc758 \uc7a0\uc7ac\uc801 \ub300\uc548 \uacbd\ub85c\ub97c \uc81c\uc2dc\ud569\ub2c8\ub2e4.<sup>6<\/sup><\/p>","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":true,"gt-view-count":12},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\uc57d\ub9ac\uc5ed\ud559\uc801 \uacb0\ud569: \ubc1c\uae30 \uc870\uc9c1\uc758 \ud3c9\ud65c\uadfc<\/title>\n<meta name=\"description\" content=\"\uc218\uc6a9\uccb4 \ub9e4\uac1c \uc2e0\ud638 \uc804\ub2ec(IP3, Rho-\ud0a4\ub098\uc81c, NO-cGMP)\uc774 \ub9c9\uc804\uc704\uc640 \ubb34\uad00\ud558\uac8c \uc74c\uacbd\ud574\uba74\uccb4 \ud3c9\ud65c\uadfc\uc758 \uae34\uc7a5\ub3c4\ub97c \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\uc5ec \ube44\ubc1c\uae30 \uc0c1\ud0dc\uc640 \ubc1c\uae30\ub97c \uc88c\uc6b0\ud558\ub294\uc9c0, \uadf8\ub9ac\uace0 PDE5 \uc5b5\uc81c\uc81c\uac00 \uc5ec\uae30\uc5d0 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud558\ub294\uc9c0 \uc124\uba85\ud569\ub2c8\ub2e4.\" \/>\n<meta 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