{"id":12403,"date":"2025-08-01T12:42:47","date_gmt":"2025-08-01T16:42:47","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/polycystic-kidney-disease\/"},"modified":"2026-10-06T15:38:20","modified_gmt":"2026-10-06T19:38:20","slug":"polycystic-kidney-disease","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/ko\/glossary-term\/polycystic-kidney-disease\/","title":{"rendered":"\ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[126],"glossary-product":[],"class_list":["post-12403","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-conditions"],"acf":{"gt-definition":"<p>\n        \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658(PKD)\uc740 \uc2e0\uc7a5\uc5d0 \uc561\uccb4\ub85c \ucc44\uc6cc\uc9c4 \uc218\ub9ce\uc740 \ub0ad\uc885\uc774 \uc0dd\uae30\ub294 \uac83\uc744 \ud2b9\uc9d5\uc73c\ub85c \ud558\ub294 \uc720\uc804 \uc9c8\ud658\uc73c\ub85c, \uc810\uc9c4\uc801\uc778 \uc2e0\uc7a5 \ube44\ub300\uc640 \uc2e0\uae30\ub2a5\uc758 \uc11c\uc11c\ud788 \uc9c4\ud589\ub418\ub294 \uc800\ud558\ub97c \ucd08\ub798\ud569\ub2c8\ub2e4.<sup>1<\/sup> \uc774 \uc9c8\ud658\uc740 \ub450 \uac00\uc9c0 \uc8fc\uc694 \uc720\uc804 \ud615\ud0dc, \uc989 \uc0c1\uc5fc\uc0c9\uccb4 \uc6b0\uc131 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658(ADPKD)\uacfc \uc0c1\uc5fc\uc0c9\uccb4 \uc5f4\uc131 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658(ARPKD)\uc73c\ub85c \uc874\uc7ac\ud569\ub2c8\ub2e4.<sup>2<\/sup> ADPKD\uac00 \ub354 \ud754\ud558\uc5ec \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc57d 400-1,000\uba85\ub2f9 1\uba85\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ubc18\uba74, ARPKD\ub294 \ub354 \ub4dc\ubb3c\uc5b4 \ucd9c\uc0dd\uc544 \uc57d 20,000-40,000\uba85\ub2f9 1\uba85\uc5d0\uc11c \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<sup>3<\/sup>\n    <\/p>\n    <p>\n        ADPKD\ub294 \uc2e0\uc7a5 \ube44\ub300\uc640 \uc2ec\uc7a5, \uac04, \ucdcc\uc7a5, \ube44\uc7a5, \uc9c0\uc8fc\ub9c9 \ub4f1 \uc2e0\uc7a5 \uc678 \uc7a5\uae30 \uce68\ubc94\uc744 \ub3d9\ubc18\ud558\ub294 \uc591\uce21\uc131 \uc2e0\ub0ad\uc885 \ud615\uc131\uc744 \ud2b9\uc9d5\uc73c\ub85c \ud558\ub294 \ub2e4\uae30\uad00\uc131 \uc9c4\ud589\uc131 \uc720\uc804 \uc9c8\ud658\uc785\ub2c8\ub2e4.<sup>4<\/sup> \uc774 \uc9c8\ud658\uc740 \uc8fc\ub85c \ub450 \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub85c \ubc1c\uc0dd\ud558\ub294\ub370, \uc0ac\ub840\uc758 \uc57d 85%\ub97c \ucc28\uc9c0\ud558\ub294 PKD1(\uc5fc\uc0c9\uccb4 16p13.3)\uacfc \uc57d 15%\ub97c \ucc28\uc9c0\ud558\ub294 PKD2(4q21)\uc785\ub2c8\ub2e4.<sup>5<\/sup> \uc18c\uc218(1%\uc5d0 \ud6e8\uc52c \ubabb \ubbf8\uce58\ub294)\uc758 \uc0ac\ub840\uc5d0\uc11c\ub294 GANAB \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uad00\uc5ec\ud558\uba70, \uc774 \uacbd\uc6b0 \uc2e0\uc7a5 \ud45c\ud604\ud615\uc740 \ub354 \uacbd\ubbf8\ud558\uc9c0\ub9cc \uac04 \uc9c8\ud658\uc774 \ub354 \ub450\ub4dc\ub7ec\uc9d1\ub2c8\ub2e4.<sup>6<\/sup>\n    <\/p>\n    <p>\n        PKD\uc758 \ubcd1\ud0dc\uc0dd\ub9ac\uc5d0\ub294 \ud3f4\ub9ac\uc2dc\uc2a4\ud2f4 \ub2e8\ubc31\uc9c8(PC1 \ubc0f PC2)\uc758 \uae30\ub2a5 \uc774\uc0c1\uc774 \uad00\uc5ec\ud558\uba70, \uc774 \ub2e8\ubc31\uc9c8\uc740 \uc2e0\uc7a5 \uc0c1\ud53c\uc138\ud3ec\uc758 \uc77c\ucc28 \uc12c\ubaa8\uc5d0 \uc874\uc7ac\ud558\uace0 \uc138\ud3ec \uc99d\uc2dd, \ubd84\ud654 \ubc0f \uccb4\uc561 \ubd84\ube44\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<sup>7<\/sup> \uc774 \ub2e8\ubc31\uc9c8\ub4e4\uc740 \uc138\ud3ec \ub0b4 \uce7c\uc298 \ub18d\ub3c4\uc640 \uace0\ub9ac\ud615 \uc544\ub370\ub178\uc2e0 \uc77c\uc778\uc0b0(cAMP) \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc870\uc808\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacbd\ub85c\uc758 \uae30\ub2a5 \uc7a5\uc560\ub294 \uc8fc\ub85c \ub0ad\uc131 \uc12c\uc720\uc99d \ub9c9\uad00\ud1b5 \uc804\ub3c4 \uc870\uc808\uc778\uc790(CFTR)\ub97c \ud1b5\ud55c \uad00\uac15\ub9c9\uc758 \uc5fc\ud654\ubb3c \ubd84\ube44 \uc99d\uac00\ub85c \uc774\uc5b4\uc838 \ub0ad\uc885 \ub0b4 \uccb4\uc561 \ucd95\uc801\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4.<sup>8<\/sup>\n    <\/p>\n    <p>\n        \uc9c8\ubcd1\uc774 \uc9c4\ud589\ud568\uc5d0 \ub530\ub77c \ub0ad\uc885\uc758 \uc9c0\uc18d\uc801\uc778 \ud655\uc7a5\uc774 \uc2e0\uc7a5 \ud608\uad00\uc744 \uc555\ubc15\ud558\uc5ec \uc2e0\uc7a5 \ub0b4 \ud5c8\ud608\uacfc \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc758 \ud65c\uc131\ud654\ub97c \uc77c\uc73c\ud0a4\uba70, \uc774\ub294 ADPKD\uc758 \ud754\ud55c \ucd08\uae30 \uc99d\uc0c1\uc778 \uace0\ud608\uc555\uc758 \uc6d0\uc778\uc774 \ub429\ub2c8\ub2e4.<sup>9<\/sup> \ub0ad\uc885\uc740 \ub610\ud55c \uc8fc\ubcc0 \uc2e0\uc7a5 \uc2e4\uc9c8\uc5d0\uc11c \uc5fc\uc99d \ubc18\uc751\uc744 \uc720\ubc1c\ud558\uc5ec \uc2e0\uc7a5 \uc12c\uc720\ud654\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc810\uc9c4\uc801\uc778 \ub0ad\uc885 \ud655\uc7a5, \uc804\uc2e0 \ud608\uad00 \uc800\ud56d \uc99d\uac00, \ub098\ud2b8\ub968 \uc800\ub958, \uc9c4\ud589\ud558\ub294 \uc2e0\uc7a5 \uc12c\uc720\ud654\ub294 \uacb0\uad6d \ub9ce\uc740 \ud658\uc790\uc5d0\uc11c \ub9d0\uae30 \uc2e0\uc7a5 \uc9c8\ud658(ESKD)\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4.<sup>10<\/sup>\n    <\/p>\n    <p>\n        ADPKD \ud658\uc790\uc5d0\uc11c \uc784\uc0c1 \uc99d\uc0c1\uc740 \uc77c\ubc18\uc801\uc73c\ub85c 30\ub300 \ub610\ub294 40\ub300\uac00 \ub418\uc5b4\uc11c\uc57c \ub098\ud0c0\ub098\ub294 \ubc18\uba74, ARPKD\ub294 \ud754\ud788 \uc8fc\uc0b0\uae30 \ub610\ub294 \uc720\uc544\uae30 \ucd08\uae30\uc5d0 \ub354 \uc2ec\ud55c \uc99d\uc0c1\uc73c\ub85c \ubc1c\ud604\ud569\ub2c8\ub2e4.<sup>11<\/sup> \ud754\ud55c \ud569\ubcd1\uc99d\uc73c\ub85c\ub294 \uace0\ud608\uc555, \uc2e0\uc7a5 \ud1b5\uc99d, \uc694\ub85c \uac10\uc5fc, \uc2e0\uc7a5 \uacb0\uc11d, \uadf8\ub9ac\uace0 \uacb0\uad6d \ud22c\uc11d\uc774\ub098 \uc774\uc2dd\uc774 \ud544\uc694\ud55c \uc2e0\ubd80\uc804\uc774 \uc788\uc2b5\ub2c8\ub2e4.<sup>12<\/sup>\n    <\/p>","gt-synonyms":"ADPKD, \uc131\uc778 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658, \uc0c1\uc5fc\uc0c9\uccb4 \uc6b0\uc131 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658, PKD, ARPKD, \uc0c1\uc5fc\uc0c9\uccb4 \uc5f4\uc131 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658, \uc601\uc544 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658, \ud3ec\ud130 I\ud615 \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658, \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658","gt-citation":"[1] Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters DJM, Torres VE. Polycystic kidney disease. Nat Rev Dis Primers. 2018 Dec 6;4(1):50. DOI: 10.1038\/s41572-018-0047-y\n\n[2] Mahboob M, Rout P, Leslie SW, Bokhari SRA. Autosomal Dominant Polycystic Kidney Disease. StatPearls [Internet]. 2024 Mar 20. PMID: 30523303\n\n[3] Harris PC, Torres VE. Polycystic kidney disease. Annu Rev Med. 2009;60:321-37. DOI: 10.1146\/annurev.med.60.101707.125712\n\n[4] Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet. 2007;369(9569):1287-1301. DOI: 10.1016\/S0140-6736(07)60601-1\n\n[5] Chebib FT, Torres VE. Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2016. Am J Kidney Dis. 2016;67(5):792-810. DOI: 10.1053\/j.ajkd.2015.07.037\n\n[6] Porath B, Gainullin VG, Cornec-Le Gall E, et al. Mutations in GANAB, Encoding the Glucosidase II\u03b1 Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease. Am J Hum Genet. 2016;98(6):1193-1207. DOI: 10.1016\/j.ajhg.2016.05.004\n\n[7] Nauli SM, Alenghat FJ, Luo Y, et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003;33(2):129-137. DOI: 10.1038\/ng1076\n\n[8] Hanaoka K, Qian F, Boletta A, et al. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000;408(6815):990-994. DOI: 10.1038\/35050128\n\n[9] Chapman AB, Johnson A, Gabow PA, Schrier RW. The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med. 1990;323(16):1091-1096. DOI: 10.1056\/NEJM199010183231602\n\n[10] Grantham JJ, Torres VE, Chapman AB, et al. Volume progression in polycystic kidney disease. N Engl J Med. 2006;354(20):2122-2130. DOI: 10.1056\/NEJMoa054341","gt-clinical-context":"<p>\n        \ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658(PKD)\uc740 \uc2e0\uc7a5\ud559 \uc9c4\ub8cc\uc5d0\uc11c \uc911\uc694\ud55c \uc784\uc0c1\uc801 \uacfc\uc81c\ub85c, \ud658\uc790 \uad00\ub9ac, \uc120\ubcc4\uac80\uc0ac \ubc0f \uce58\ub8cc\uc5d0 \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uac16\uc2b5\ub2c8\ub2e4.<sup>1<\/sup> PKD\uc758 \uc784\uc0c1\uc801 \ub9e5\ub77d\uc740 \uc9c4\ub2e8, \uc9c8\ubcd1 \ubaa8\ub2c8\ud130\ub9c1, \ud569\ubcd1\uc99d \uad00\ub9ac, \uadf8\ub9ac\uace0 \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ub2a6\ucd94\uace0 \uc2e0\uc7a5 \uae30\ub2a5\uc744 \ubcf4\uc874\ud558\uae30 \uc704\ud55c \uce58\ub8cc \uc804\ub7b5\uc744 \ud3ec\uad04\ud569\ub2c8\ub2e4.\n    <\/p>\n    <p>\n        ADPKD\uc758 \uc9c4\ub2e8\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc601\uc0c1 \uac80\uc0ac\ub97c \ud1b5\ud574 \uc774\ub8e8\uc5b4\uc9c0\uba70, \uc811\uadfc\uc131, \uc548\uc804\uc131, \ube44\uc6a9 \ud6a8\uc728\uc131 \ub54c\ubb38\uc5d0 \ucd08\uc74c\ud30c\uac00 \uac00\uc7a5 \ud754\ud55c \ucd08\uae30 \uac80\uc0ac \ubc29\ubc95\uc785\ub2c8\ub2e4.<sup>2<\/sup> \uc9c4\ub2e8 \uae30\uc900\uc740 \uc5f0\ub839\uc5d0 \ub530\ub77c \ub2e4\ub974\uba70, \uc80a\uc740 \ud658\uc790(15-39\uc138)\ub294 \uace0\ub839\uc790\ubcf4\ub2e4 \ub354 \uc801\uc740 \uc218\uc758 \ub0ad\uc885\uc73c\ub85c \uc9c4\ub2e8\ub429\ub2c8\ub2e4.<sup>3<\/sup> \uc790\uae30\uacf5\uba85\uc601\uc0c1(MRI)\uacfc \ucef4\ud4e8\ud130 \ub2e8\uce35\ucd2c\uc601(CT)\uc740 \uc791\uc740 \ub0ad\uc885 \uac80\ucd9c\uc5d0 \ub354 \ub192\uc740 \ubbfc\uac10\ub3c4\ub97c \uc81c\uacf5\ud558\uba70, \ubcf4\ub2e4 \uc0c1\uc138\ud55c \ud3c9\uac00\uac00 \ud544\uc694\ud558\uac70\ub098 \ucd08\uc74c\ud30c \uacb0\uacfc\uac00 \ubaa8\ud638\ud560 \ub54c \ud754\ud788 \uc0ac\uc6a9\ub429\ub2c8\ub2e4.<sup>4<\/sup> \uc720\uc804\uc790 \uac80\uc0ac\ub294 \ud2b9\ud788 \ube44\uc804\ud615\uc801 \uc591\uc0c1, \uc870\uae30 \ubc1c\ubcd1 \uc9c8\ud658, \ub610\ub294 \uac00\uc871\uacc4\ud68d \ubaa9\uc801\uc758 \uacbd\uc6b0\uc5d0 \uc810\uc810 \ub354 \ub9ce\uc774 \ud65c\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<sup>5<\/sup>\n    <\/p>\n    <p>\n        \uc9c8\ubcd1 \uc9c4\ud589 \ubaa8\ub2c8\ud130\ub9c1\uc740 PKD \uad00\ub9ac\uc5d0 \ud544\uc218\uc801\uc774\uba70, \ucd1d \uc2e0\uc7a5 \uc6a9\uc801(TKV)\uc774 \uc9c8\ubcd1 \uc9c4\ud589\uc758 \uac00\uc7a5 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \ubd80\uc0c1\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<sup>6<\/sup> Mayo \ubd84\ub958 \uccb4\uacc4(\ud074\ub798\uc2a4 1A, 1B, 1C, 1D, 1E)\ub294 \ud658\uc790\ub97c \uc9c8\ubcd1 \uacb0\uacfc \uc545\ud654 \uc704\ud5d8\uc774 \uac00\uc7a5 \ub0ae\uc740 \uad70\ubd80\ud130 \uac00\uc7a5 \ub192\uc740 \uad70\uae4c\uc9c0 \uce35\ud654\ud558\uba70, \ud074\ub798\uc2a4 1C\u20131E\ub294 \ub9d0\uae30 \uc2e0\uc7a5 \uc9c8\ud658(ESKD)\uc758 \ub192\uc740 \uc704\ud5d8\uacfc \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<sup>7<\/sup> \uc774 \ubd84\ub958\ub294 \ubcf4\ub2e4 \uc801\uadf9\uc801\uc778 \uad00\ub9ac \uc811\uadfc\ubc95\uc774 \ub3c4\uc6c0\uc774 \ub420 \uace0\uc704\ud5d8 \ud658\uc790\ub97c \uc2dd\ubcc4\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.\n    <\/p>\n    <p>\n        \uace0\ud608\uc555\uc740 ADPKD\uc758 \ud754\ud55c \ucd08\uae30 \uc99d\uc0c1\uc73c\ub85c, \ud754\ud788 \uc2e0\uc7a5 \uae30\ub2a5\uc758 \uc720\uc758\ud55c \uc800\ud558\ubcf4\ub2e4 \uba3c\uc800 \ub098\ud0c0\ub098\uba70, \ub354 \ube60\ub978 \uc9c8\ubcd1 \uc9c4\ud589 \ubc0f \uc2ec\ud608\uad00 \uc774\ud658\uc728 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<sup>8<\/sup> \ud608\uc555 \uc870\uc808\uc740 ADPKD \uad00\ub9ac\uc758 \ud575\uc2ec\uc774\uba70, KDIGO 2025\ub294 \uc2e0\uc7a5 \uae30\ub2a5\uc774 \ubcf4\uc874\ub41c 18-49\uc138\uc758 \uc0ac\ub78c\uc5d0\uac8c 110\/75 mmHg \uc774\ud558(\uac00\uc815 \uce21\uc815, \ub0b4\uc57d\uc131\uc774 \uc788\ub294 \uacbd\uc6b0)\ub97c \ubaa9\ud45c\ub85c \ud560 \uac83\uc744 \uad8c\uace0\ud558\uace0, \uadf8 \uc678\uc758 \uc0ac\ub78c\uc5d0\uac8c\ub294 \uac1c\ubcc4\ud654\ub41c \ubaa9\ud45c\ub97c \uad8c\uace0\ud569\ub2c8\ub2e4.<sup>9<\/sup> \uc548\uc9c0\uc624\ud150\uc2e0 \uc804\ud658\ud6a8\uc18c \uc5b5\uc81c\uc81c(ACEI)\uc640 \uc548\uc9c0\uc624\ud150\uc2e0 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c(ARB)\ub294 \ud608\uc555 \uc870\uc808\uc744 \ub118\uc5b4\uc11c\ub294 \uc7a0\uc7ac\uc801 \uc2e0\uc7a5 \ubcf4\ud638 \ud6a8\uacfc \ub54c\ubb38\uc5d0 \uc120\ud638\ub418\ub294 \ud56d\uace0\ud608\uc555\uc81c\uc785\ub2c8\ub2e4.<sup>10<\/sup>\n    <\/p>\n    <p>\n        \ud1b5\uc99d \uad00\ub9ac\ub294 PKD \uce58\ub8cc\uc758 \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \uce21\uba74\uc73c\ub85c, \ub9ce\uc740 \ud658\uc790\uac00 \ub0ad\uc885 \ud655\ub300, \uac10\uc5fc \ub610\ub294 \uc2e0\uc7a5 \uacb0\uc11d\uacfc \uad00\ub828\ub41c \uae09\uc131 \ub610\ub294 \ub9cc\uc131 \ud1b5\uc99d\uc744 \uacbd\ud5d8\ud569\ub2c8\ub2e4.<sup>11<\/sup> \uce58\ub8cc \uc811\uadfc\ubc95\uc740 \ubcf4\uc874\uc801 \uc870\uce58(\uc9c4\ud1b5\uc81c, \uc0bc\ud658\uacc4 \ud56d\uc6b0\uc6b8\uc81c)\ubd80\ud130 \uc911\uc99d \uc0ac\ub840\uc758 \uc911\uc7ac\uc801 \uc2dc\uc220(\ub0ad\uc885 \ud761\uc778, \ubcf5\uac15\uacbd \ub0ad\uc885 \uac1c\ucc3d\uc220)\uae4c\uc9c0 \ub2e4\uc591\ud569\ub2c8\ub2e4.<sup>12<\/sup>\n    <\/p>\n    <p>\n        \ub0ad\uc885 \uac10\uc5fc\uc740 \ud50c\ub8e8\uc624\ub85c\ud034\ub180\ub860, \ud2b8\ub9ac\uba54\ud1a0\ud504\ub9bc-\uc124\ud30c\uba54\ud1a1\uc0ac\uc878, \ud074\ub9b0\ub2e4\ub9c8\uc774\uc2e0\uacfc \uac19\uc774 \ub0ad\uc885 \ud22c\uacfc\uc131\uc774 \uc88b\uc740 \ud56d\uc0dd\uc81c\ub85c \uc2e0\uc18d\ud558\uac8c \uce58\ub8cc\ud574\uc57c \ud569\ub2c8\ub2e4.<sup>13<\/sup> \uc9c0\uc18d\uc801\uc778 \uac10\uc5fc\uc740 \ub0ad\uc885 \ubc30\uc561\uc774\ub098, \ub9d0\uae30 \uc0ac\ub840\uc5d0\uc11c\ub294 \uc2e0\uc7a5 \uc808\uc81c\uc220\uc774 \ud544\uc694\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>14<\/sup>\n    <\/p>\n    <p>\n        \uc2e0\uc7a5 \uacb0\uc11d\uc740 ADPKD \ud658\uc790\uc758 \uc57d 20%\uc5d0\uc11c \ubc1c\uc0dd\ud558\uba70, \uc694\uc0b0 \uacb0\uc11d\uc774 \uac00\uc7a5 \ud754\ud558\uace0 \uadf8\ub2e4\uc74c\uc774 \uc625\uc0b4\uc0b0\uce7c\uc298 \uacb0\uc11d\uc785\ub2c8\ub2e4.<sup>15<\/sup> \uad00\ub9ac\uc5d0\ub294 \uc218\ubd84 \uc12d\ucde8 \uc99d\uac00, \uad6c\uc5f0\uc0b0\uce7c\ub968\uc744 \uc774\uc6a9\ud55c \uc18c\ubcc0 \uc54c\uce7c\ub9ac\ud654(\ud2b9\ud788 \uc694\uc0b0 \uacb0\uc11d\uc758 \uacbd\uc6b0), \uadf8\ub9ac\uace0 \ud544\uc694\ud55c \uacbd\uc6b0 \ud45c\uc900 \uc911\uc7ac\uc801 \uc811\uadfc\ubc95\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4.<sup>16<\/sup>\n    <\/p>\n    <p>\n        \ubc14\uc18c\ud504\ub808\uc2e0 V2 \uc218\uc6a9\uccb4 \uae38\ud56d\uc81c\uc778 \ud1a8\ubc25\ud0c4\uc740 ADPKD \ud2b9\uc774\uc801 \uce58\ub8cc\uc5d0\uc11c \uc911\uc694\ud55c \uc9c4\uc804\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<sup>17<\/sup> \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ud1a8\ubc25\ud0c4\uc740 TKV \uc99d\uac00\uc640 \ucd94\uc815 \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728(eGFR) \uac10\uc18c\ub97c \ub2a6\ucd94\ub294 \ud6a8\uacfc\ub97c \uc785\uc99d\ud558\uc600\uc2b5\ub2c8\ub2e4.<sup>18<\/sup> \uadf8\ub7ec\ub098 \uc0ac\uc6a9 \uc2dc\uc5d0\ub294 \uc2e0\uc911\ud55c \ud658\uc790 \uc120\uc815, \uc7a0\uc7ac\uc801 \uac04\ub3c5\uc131\uc5d0 \ub300\ud55c \ubaa8\ub2c8\ud130\ub9c1, \ub2e4\ub1e8 \ubc0f \ub2e4\uc74c\uc99d\uacfc \uac19\uc740 \ubd80\uc791\uc6a9 \uad00\ub9ac\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<sup>19<\/sup>\n    <\/p>\n    <p>\n        \ubaa8\ub4e0 PKD \ud658\uc790\uc5d0\uac8c\ub294 \ubc14\uc18c\ud504\ub808\uc2e0\uc744 \uc5b5\uc81c\ud558\uace0 cAMP \uc0dd\uc131\uc744 \uc904\uc774\uae30 \uc704\ud55c \uc218\ubd84 \uc12d\ucde8 \uc99d\uac00(\ud558\ub8e8 \uc57d 2-3\ub9ac\ud130), \ub098\ud2b8\ub968 \uc81c\ud55c(\ud558\ub8e8 &lt;2\uadf8\ub7a8), \uaddc\uce59\uc801\uc778 \uc2e0\uccb4 \ud65c\ub3d9 \ub4f1 \uc0dd\ud65c \uc2b5\uad00 \uac1c\uc120\uc774 \uad8c\uc7a5\ub429\ub2c8\ub2e4.<sup>20<\/sup>\n    <\/p>\n    <p>\n        ESKD\ub85c \uc9c4\ud589\ud558\ub294 \ud658\uc790\uc758 \uacbd\uc6b0 \uc2e0\ub300\uccb4\uc694\ubc95 \uc120\ud0dd\uc9c0\ub85c \ud22c\uc11d\uacfc \uc2e0\uc7a5 \uc774\uc2dd\uc774 \uc788\uc73c\uba70, \uc801\ud569\ud55c \ud6c4\ubcf4\uc5d0\uac8c\ub294 \ud6c4\uc790\uac00 \ub354 \uc6b0\uc218\ud55c \uacb0\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<sup>21<\/sup> \uac70\ub300\ud558\uac8c \ube44\ub300\ud574\uc9c4 \uc2e0\uc7a5\uc774 \uc0c1\ub2f9\ud55c \uc99d\uc0c1\uc744 \uc720\ubc1c\ud558\ub294 \uacbd\uc6b0 \ub610\ub294 \uc774\uc2dd\uc744 \uc704\ud55c \uacf5\uac04 \ud655\ubcf4\ub97c \uc704\ud574 \uc2e0\uc7a5 \uc808\uc81c\uc220\uc774 \ud544\uc694\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>22<\/sup>\n    <\/p>\n    <p>\n        \uc720\uc804 \uc0c1\ub2f4\uc740 PKD \ud658\uc790\uc640 \uadf8 \uac00\uc871\uc744 \uc704\ud55c \uce58\ub8cc\uc758 \uc911\uc694\ud55c \uad6c\uc131 \uc694\uc18c\ub85c, \uc720\uc804 \uc591\uc2dd, \uc7ac\ubc1c \uc704\ud5d8 \ubc0f \uc0dd\uc2dd \uc120\ud0dd\uc9c0\uc5d0 \ub300\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<sup>23<\/sup> \ucc29\uc0c1 \uc804 \uc720\uc804 \uc9c4\ub2e8\uc740 \uccb4\uc678\uc218\uc815\uc744 \ubc1b\ub294 \ucee4\ud50c\uc5d0\uac8c PKD \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc5c6\ub294 \ubc30\uc544\ub97c \uc120\ud0dd\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<sup>24<\/sup>\n    <\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":120},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658 | \uc720\uc804, \uc9c4\ub2e8, \ud1a8\ubc25\ud0c4 \uce58\ub8cc - Rigicon \uc6a9\uc5b4\uc9d1<\/title>\n<meta name=\"description\" content=\"\ub2e4\ub0ad\uc131 \uc2e0\uc7a5 \uc9c8\ud658\uc740 \uc2e0\uc7a5\uc5d0 \ub0ad\uc885\uc774 \uc0dd\uae30\ub294 \uc720\uc804 \uc9c8\ud658\uc785\ub2c8\ub2e4. \uc8fc\uc694 \uc99d\uc0c1\uacfc \uc9c4\ub2e8, \uc57d\ubb3c \uce58\ub8cc \ubc0f 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