{"id":12367,"date":"2025-07-22T08:27:33","date_gmt":"2025-07-22T12:27:33","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/anti-inflammatory\/"},"modified":"2026-03-22T06:32:14","modified_gmt":"2026-03-22T10:32:14","slug":"anti-inflammatory","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/ko\/glossary-term\/anti-inflammatory\/","title":{"rendered":"\ud56d\uc5fc\uc99d\uc81c"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[114],"glossary-product":[],"class_list":["post-12367","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-agents"],"acf":{"gt-definition":"<p>\ud56d\uc5fc\uc99d\uc81c\ub294 \uc5fc\uc99d\uacfc \ud1b5\uc99d, \ubd80\uae30, \ubc1c\uc5f4 \ub4f1 \uad00\ub828 \uc99d\uc0c1\uc744 \uc904\uc774\uae30 \uc704\ud574 \uace0\uc548\ub41c \ub2e4\uc591\ud55c \uc57d\uc81c\uad70\uc785\ub2c8\ub2e4. \uac00\uc7a5 \uc77c\ubc18\uc801\uc778 \uc885\ub958\uc758 \ud56d\uc5fc\uc99d\uc81c\ub294 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c(NSAID)\ub85c, \uc774\ub294 \uc8fc\ub85c \uc0ac\uc774\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c(COX) \ud6a8\uc18c\uc758 \uc5b5\uc81c\ub97c \ud1b5\ud574 \uce58\ub8cc \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4.\u00a4\u00a4<sup>1<\/sup> \uc774\ub7ec\ud55c \ud6a8\uc18c\ub294 \uc5fc\uc99d, \ud1b5\uc99d, \ubc1c\uc5f4 \ub4f1 \ub2e4\uc591\ud55c \uc0dd\ub9ac\uc801 \uacfc\uc815\uc744 \uc911\uc7ac\ud558\ub294 \ud638\ub974\ubaac \uc720\uc0ac \ud654\ud569\ubb3c\uc778 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc758 \uc0dd\uc131\uc744 \ub2f4\ub2f9\ud569\ub2c8\ub2e4.<sup>2<\/sup><\/p>\n \n <p>COX \ud6a8\uc18c\ub294 COX-1\uacfc COX-2\ub77c\ub294 \ub450 \uac00\uc9c0 \uc774\uc0c1\uc758 \ubcc4\uac1c\uc758 \uc774\uc18c\ud615\uc73c\ub85c \uc874\uc7ac\ud569\ub2c8\ub2e4. COX-1\uc740 \ub300\ubd80\ubd84\uc758 \uc870\uc9c1\uc5d0\uc11c \uad6c\uc131\uc801\uc73c\ub85c \ubc1c\ud604\ub418\uba70 \uc704 \uc810\ub9c9 \ubcf4\ud638, \ud608\uc18c\ud310 \uc751\uc9d1, \uc2e0\uc7a5 \ud608\ub958 \uc870\uc808\uacfc \uac19\uc740 \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4. \u00a4\u00a4<sup>3<\/sup> \ubc18\uba74 COX-2\ub294 \uc8fc\ub85c \uc0ac\uc774\ud1a0\uce74\uc778\uacfc \uac19\uc740 \uc5fc\uc99d \uc790\uadf9\uc5d0 \ubc18\uc751\ud558\uc5ec \uc720\ub3c4\ub418\uba70 \ud1b5\uc99d, \uc5f4, \ubc1c\uc801 \ubc0f \uc5fc\uc99d\uc758 \uc8fc\uc694 \uc9d5\ud6c4\uc5d0 \uae30\uc5ec\ud558\ub294 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc744 \uc0dd\uc0b0\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ubd93\uae30.<sup>4<\/sup><\/p>\n \n <p>\ud56d\uc5fc\uc99d\uc81c\ub294 COX \ud6a8\uc18c\uc5d0 \ub300\ud55c \uc120\ud0dd\uc131\uc5d0 \ub530\ub77c \ubd84\ub958\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ube44\uc120\ud0dd\uc801 NSAID\ub294 COX-1\uacfc COX-2\ub97c \ubaa8\ub450 \uc5b5\uc81c\ud558\ub294 \ubc18\uba74, \uc120\ud0dd\uc801 COX-2 \uc5b5\uc81c\uc81c\ub294 COX-2 \ud6a8\uc18c\ub97c \uc6b0\uc120\uc801\uc73c\ub85c \ud45c\uc801\uc73c\ub85c \uc0bc\uc2b5\ub2c8\ub2e4.\u00a4\u00a4<sup>5<\/sup> \uc774 \uc120\ud0dd\uc131 \ud504\ub85c\ud544\uc740 \uc774\ub7ec\ud55c \uc57d\ubb3c\uc758 \uce58\ub8cc \ud6a8\ub2a5\uacfc \ubd80\uc791\uc6a9 \ud504\ub85c\ud544 \ubaa8\ub450\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ube44\uc120\ud0dd\uc801 NSAID\ub294 \uc5fc\uc99d\uc5d0 \ud6a8\uacfc\uc801\uc774\uc9c0\ub9cc COX-1 \uc5b5\uc81c\ub85c \uc778\ud574 \uc704 \uc790\uadf9\uc744 \uc720\ubc1c\ud558\uace0 \ucd9c\ud608 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ubc18\uba74, \uc120\ud0dd\uc801 COX-2 \uc5b5\uc81c\uc81c\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc704 \uc810\ub9c9\uc744 \ubcf4\ud638\ud558\uc9c0\ub9cc \uc7a5\uae30\uac04 \uc0ac\uc6a9 \uc2dc \uc2ec\ud608\uad00 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<sup>6<\/sup><\/p>\n \n <p>NSAID \uc678\uc5d0 \ub2e4\ub978 \uc885\ub958\uc758 \ud56d\uc5fc\uc99d\uc81c\uc5d0\ub294 \ub2e4\uc911 \uc5fc\uc99d \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \uc791\uc6a9\ud558\ub294 \ucf54\ub974\ud2f0\ucf54\uc2a4\ud14c\ub85c\uc774\ub4dc\uc640 \ub9cc\uc131 \uc5fc\uc99d \uc0c1\ud0dc\uc640 \uad00\ub828\ub41c \uba74\uc5ed \uccb4\uacc4\uc758 \ud2b9\uc815 \uad6c\uc131 \uc694\uc18c\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc9c8\ubcd1 \uc218\uc815 \ud56d\ub958\ub9c8\ud2f0\uc2a4\uc81c(DMARD)\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4.<sup>7<\/sup> \uc801\uc808\ud55c \ud56d\uc5fc\uc99d\uc81c\uc758 \uc120\ud0dd\uc740 \uae30\uc800 \uc9c8\ud658, \uc99d\uc0c1\uc758 \uc911\uc99d\ub3c4, \ud658\uc790\ubcc4 \uc694\uc778, \ud658\uc790\uc758 \uc704\ud5d8-\ud61c\ud0dd \ud504\ub85c\ud544\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \uc57d\ubb3c \uce58\ub8cc.<sup>8<\/sup><\/p> <p>\ud56d\uc5fc\uc99d\uc81c\ub294 \uc5fc\uc99d \ubc18\uc751\uc744 \uc5b5\uc81c\ud558\ub294 \uc57d\ubb3c\uad70\uc73c\ub85c, \ube44\ub1e8\uae30\uacfc\uc5d0\uc11c \uc804\ub9bd\uc120\uc5fc, \uac04\uc9c8\uc131 \ubc29\uad11\uc5fc, \uc218\uc220 \ud6c4 \ud1b5\uc99d \uad00\ub9ac \ub4f1\uc5d0 \uad11\ubc94\uc704\ud558\uac8c \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c(NSAIDs)\uc640 \ucf54\ub974\ud2f0\ucf54\uc2a4\ud14c\ub85c\uc774\ub4dc\uac00 \ub300\ud45c\uc801\uc785\ub2c8\ub2e4. EAU \ub9cc\uc131 \uace8\ubc18\ud1b5 \uac00\uc774\ub4dc\ub77c\uc778\uc5d0\uc11c\ub294 IIIA\ud615 \ub9cc\uc131 \uc804\ub9bd\uc120\uc5fc\uc758 \ucd08\uae30 \uce58\ub8cc\ub85c NSAIDs\ub97c \uad8c\uc7a5\ud569\ub2c8\ub2e4.<\/p>","gt-synonyms":"\ud56d\uc5fc\uc99d\uc81c, \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c, NSAID, \ud56d\uc5fc\uc99d\uc81c, \ube44\ub9c8\uc57d\uc131 \uc9c4\ud1b5\uc81c, COX \uc5b5\uc81c\uc81c, \uc2dc\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c \uc5b5\uc81c\uc81c, \ud574\uc5f4\uc9c4\ud1b5\uc81c, \ube44\ub9c8\uc57d\uc131 \uc9c4\ud1b5\uc81c, \ud56d\ub958\ub9c8\ud2f0\uc2a4\uc81c","gt-citation":"[1] Vane JR, Botting RM. Anti-inflammatory drugs and their mechanism of action. Inflamm Res. 1998 Oct;47 Suppl 2:S78-87. DOI: 10.1007\/s000110050284\n\n[2] Ghlichloo I, Gerriets V. Nonsteroidal Anti-inflammatory Drugs (NSAIDs). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547742\/\n\n[3] Osafo N, Agyare C, Obiri DD, Antwi AO. Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs. IntechOpen. 2017 Aug 23. DOI: 10.5772\/68090\n\n[4] Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000. DOI: 10.1161\/ATVBAHA.110.207449\n\n[5] Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest. 2006 Jan;116(1):4-15. DOI: 10.1172\/JCI27291\n\n[6] Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S3. DOI: 10.1186\/ar4175\n\n[7] Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S2. DOI: 10.1186\/ar4174\n\n[8] Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020 Oct;180:114147. DOI: 10.1016\/j.bcp.2020.114147","gt-clinical-context":"<p>\ud56d\uc5fc\uc99d\uc81c\ub294 \ud604\ub300 \uc784\uc0c1 \uc2e4\uc2b5\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70 \ud1b5\uc99d, \uc5fc\uc99d, \ubc1c\uc5f4\uc744 \ud2b9\uc9d5\uc73c\ub85c \ud558\ub294 \uad11\ubc94\uc704\ud55c \uc0c1\ud0dc\ub97c \uad00\ub9ac\ud558\ub294 1\ucc28 \uc57d\uc81c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.\u00a4<sup>1<\/sup> \uc774\ub7ec\ud55c \uc57d\ubb3c\uc758 \uc784\uc0c1 \uc801\uc6a9\uc740 \ub958\ub9c8\ud2f0\uc2a4\ud559, \uc815\ud615\uc678\uacfc, 1\ucc28 \uc9c4\ub8cc, \uc751\uae09\uc758\ud559\uc744 \ube44\ub86f\ud55c \uc5ec\ub7ec \uc758\ub8cc \uc804\ubb38 \ubd84\uc57c\uc5d0 \uac78\uccd0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n \n <p>\uae09\uc131 \uc0c1\ud669\uc5d0\uc11c \ud56d\uc5fc\uc99d\uc81c\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc678\uc0c1\uc131 \ubd80\uc0c1, \uc218\uc220 \ud6c4 \ud1b5\uc99d, \uce58\uacfc \uc2dc\uc220, \ubc1c\uc5f4 \uad00\ub9ac \ub4f1\uc758 \uc9c8\ud658\uc5d0 \ucc98\ubc29\ub429\ub2c8\ub2e4.<sup>2<\/sup> \ud56d\uc5fc\uc99d\uc81c\ub294 \ube60\ub978 \uc791\uc6a9 \uac1c\uc2dc\ub85c \uc778\ud574 \uae30\uc800 \uc9c8\ud658\uc774 \ud574\uacb0\ub418\uac70\ub098 \ucd5c\uc885 \uce58\ub8cc\ub97c \ubc1b\ub294 \ub3d9\uc548 \uc99d\uc0c1 \uc644\ud654\ub97c \uc81c\uacf5\ud558\ub294 \ub370 \ud2b9\ud788 \uc720\uc6a9\ud569\ub2c8\ub2e4.<sup>3<\/sup> \uc608\ub97c \ub4e4\uc5b4, NSAID\ub294 \uc815\ud615\uc678\uacfc \uc218\uc220\uc774\ub098 \uce58\uacfc \ubc1c\uce58 \ud6c4\uc5d0 \ud1b5\uc99d\uacfc \uc5fc\uc99d \ubc18\uc751\uc744 \uc870\uc808\ud558\uae30 \uc704\ud574 \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ubd88\ud3b8\ud568\uacfc \uce58\uc720 \uc9c0\uc5f0.\u00a4<sup>4<\/sup><\/p>\n \n <p>\ub9cc\uc131 \uc5fc\uc99d \uc9c8\ud658\uc758 \uacbd\uc6b0 \ud56d\uc5fc\uc99d \uc57d\ubb3c\uc740 \uc7a5\uae30 \uad00\ub9ac \uc804\ub7b5\uc758 \ucd08\uc11d\uc774 \ub429\ub2c8\ub2e4. \uace8\uad00\uc808\uc5fc, \ub958\ub9c8\ud2f0\uc2a4 \uad00\uc808\uc5fc, \uac15\uc9c1\uc131 \ucc99\ucd94\uc5fc \ubc0f \uae30\ud0c0 \uc5fc\uc99d\uc131 \uad00\uc808\ubcd1\uc99d\uacfc \uac19\uc740 \uc9c8\ud658\uc740 \uae30\ub2a5\uc801 \uc0c1\ud0dc\uc640 \uc0b6\uc758 \uc9c8\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc9c0\uc18d\uc801\uc778 \ud56d\uc5fc\uc99d \uce58\ub8cc\uac00 \ud544\uc694\ud55c \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4.\u00a4<sup>5<\/sup> \uc774\ub7ec\ud55c \ub9e5\ub77d\uc5d0\uc11c \ud2b9\uc815 \ud56d\uc5fc\uc99d\uc81c \uc120\ud0dd\uc5d0\ub294 \ud6a8\ub2a5, \uc548\uc804\uc131 \ud504\ub85c\ud544, \ub3d9\ubc18 \uc9c8\ud658 \ubc0f \ud658\uc790\ubcc4 \uc694\uc778\uc744 \uc2e0\uc911\ud558\uac8c \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4.<sup>6<\/sup><\/p>\n \n <p>\ud56d\uc5fc\uc99d \uce58\ub8cc\ub97c \uc704\ud55c \ud658\uc790\ub97c \uc120\ud0dd\ud558\ub824\uba74 \ucca0\uc800\ud55c \uc784\uc0c1 \ud3c9\uac00\uc640 \uc704\ud5d8 \uacc4\uce35\ud654\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uc2ec\ud608\uad00 \uc704\ud5d8 \uc694\uc778, \uc704\uc7a5 \ubcd1\ub825, \uc2e0\uc7a5 \uae30\ub2a5, \uc5f0\ub839 \ubc0f \ubcd1\uc6a9 \uc57d\ubb3c \ubaa8\ub450\uac00 \uc57d\uc81c \uc120\ud0dd, \ubcf5\uc6a9\ub7c9 \ubc0f \uce58\ub8cc \uae30\uac04\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.\u00a4<sup>7<\/sup> \uc2ec\ud608\uad00 \uc704\ud5d8\uc774 \ub192\uc740 \ud658\uc790\uc758 \uacbd\uc6b0 \uc0c1\ub300\uc801\uc73c\ub85c \uc911\ub9bd\uc801\uc778 \uc2ec\ud608\uad00 \ud504\ub85c\ud544\ub85c \uc778\ud574 \ub098\ud504\ub85d\uc13c\uc774 \ub2e4\ub978 NSAID\ubcf4\ub2e4 \uc120\ud638\ub420 \uc218 \uc788\ub294 \ubc18\uba74, \uc704\uc7a5 \ucd9c\ud608 \uc774\ub825\uc774 \uc788\ub294 \ud658\uc790\ub294 COX-2 \uc120\ud0dd\uc801 \uc5b5\uc81c\uc81c \ub610\ub294 \ub3d9\uc2dc \uc704\uc7a5 \ubcf4\ud638 \ud6a8\uacfc\uac00 \uc788\ub294 \uae30\uc874 NSAID\uac00 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5d0\uc774\uc804\ud2b8.<sup>8<\/sup><\/p>\n \n <p>\ud56d\uc5fc\uc99d\uc81c \ud22c\uc5ec\ub294 \uc784\uc0c1 \uc2dc\ub098\ub9ac\uc624\uc640 \ud658\uc790\uc758 \ud544\uc694\uc5d0 \ub530\ub77c \ub2e4\ub985\ub2c8\ub2e4. \uacbd\uad6c \uc81c\uc81c\ub294 \uac00\uc7a5 \uc77c\ubc18\uc801\uc778 \uacbd\ub85c\ub85c \ub0a8\uc544 \uc788\uc9c0\ub9cc \uad6d\uc18c \uc81c\uc81c, \uc815\ub9e5 \ud22c\uc5ec \ubc0f \uc9c1\uc7a5 \uc88c\uc57d\uc740 \uacbd\uad6c \ud22c\uc5ec\uac00 \uae08\uae30\uc774\uac70\ub098 \ucc28\uc120\uc778 \uacbd\uc6b0 \ub300\uc548\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.\u00a4<sup>7<\/sup> \ud22c\uc5ec \uc804\ub7b5\uc740 \uae09\uc131 \uc0c1\ud0dc\uc5d0 \ub300\ud55c \ud544\uc694\uc5d0 \ub530\ub77c \ud22c\uc5ec\ud558\ub294 \uac83\ubd80\ud130 \ub9cc\uc131 \uc5fc\uc99d\uc131 \uc9c8\ud658\uc5d0 \ub300\ud55c \uc608\uc815\ub41c \ud22c\uc5ec\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ub2e4\uc591\ud558\uba70, \uce58\ub8cc \ud6a8\uacfc\ub97c \ub2ec\uc131\ud558\ub294 \ub3d9\uc548 \ubd80\uc791\uc6a9\uc744 \ucd5c\uc18c\ud654\ud558\ub294 \ub370 \ud544\uc694\ud55c \ucd5c\ub2e8 \uae30\uac04 \ub3d9\uc548 \uac00\uc7a5 \ub0ae\uc740 \uc720\ud6a8 \uc6a9\ub7c9\uc744 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