{"id":32457,"date":"2026-09-03T18:35:00","date_gmt":"2026-09-03T22:35:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32457"},"modified":"2026-09-04T06:10:00","modified_gmt":"2026-09-04T10:10:00","slug":"supositorio-intrauretral","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/supositorio-intrauretral\/","title":{"rendered":"Supositorio intrauretral"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32457","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"

El supositorio intrauretral es un sistema transuretral medicamentoso de dosis \u00fanica para la administraci\u00f3n de alprostadilo en la uretra masculina para el tratamiento de la disfunci\u00f3n er\u00e9ctil.1<\/sup> Consiste en alprostadilo, un an\u00e1logo sint\u00e9tico de la prostaglandina E1, suspendido en polietilenglicol 1450 (como excipiente) y conformado en un comprimido medicamentoso o micropellet (microsupositorio) que mide 1,4 mm de di\u00e1metro por 3 mm o 6 mm de longitud.2<\/sup> El pellet se aloja en la punta de un aplicador hueco y transl\u00facido, y se administra insertando la c\u00e1nula del aplicador en la uretra tras la micci\u00f3n.3<\/sup> El f\u00e1rmaco act\u00faa relajando el tejido circundante y dilatando los vasos sangu\u00edneos, lo que incrementa el flujo sangu\u00edneo hacia el pene y da lugar a una erecci\u00f3n.4<\/sup> Este tratamiento se conoce com\u00fanmente como MUSE (Medicated Urethral System for Erection) y est\u00e1 aprobado por la FDA como tratamiento de segunda l\u00ednea para la disfunci\u00f3n er\u00e9ctil cuando las terapias orales de primera l\u00ednea, como los inhibidores de la fosfodiesterasa tipo 5 (PDE5), resultan ineficaces.5<\/sup><\/p>\n","gt-synonyms":"MUSE, Medicated Urethral System for Erection, supositorio uretral de alprostadilo, alprostadilo transuretral, alprostadilo intrauretral, pellet uretral","gt-citation":"[1] Meda Pharmaceuticals Inc. MUSE\u00ae (alprostadil) urethral suppository. U.S. Food and Drug Administration. 2024. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/020700s032lbl.pdf\n\n[2] Leslie SW, Jain A, Iqbal OA. Alprostadil. StatPearls. 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542217\/\n\n[3] Mayo Clinic. Alprostadil (urethral route). 2023. https:\/\/www.mayoclinic.org\/drugs-supplements\/alprostadil-urethral-route\/description\/drg-20138507\n\n[4] Mount Sinai. Intraurethral Agents - Erectile Dysfunction. 2023. https:\/\/www.mountsinai.org\/care\/urology\/services\/mens-health\/male-sexual-dysfunction\/intraurethral-agents\n\n[5] Brown K, Garza E. MUSE for ED: How It Works, Side Effects, & More. Hims. 2024. https:\/\/www.hims.com\/blog\/muse-for-ed","gt-clinical-context":"

El supositorio intrauretral est\u00e1 cl\u00ednicamente indicado como tratamiento de segunda l\u00ednea para la disfunci\u00f3n er\u00e9ctil en hombres cuando la terapia oral ha fracasado.1<\/sup> El tratamiento es especialmente \u00fatil para pacientes que no toleran o presentan contraindicaciones para los inhibidores de la fosfodiesterasa tipo 5 (PDE5), como el sildenafilo.2<\/sup> La medicaci\u00f3n se administra directamente antes de la relaci\u00f3n sexual, logr\u00e1ndose habitualmente la erecci\u00f3n entre 5 y 10 minutos despu\u00e9s de la inserci\u00f3n y con una duraci\u00f3n aproximada de 30 a 60 minutos.3<\/sup><\/p>\n

El proceso de administraci\u00f3n implica introducir el aplicador en la uretra despu\u00e9s de orinar (lo que ayuda a lubricar la uretra y facilita la inserci\u00f3n), liberar el pellet de alprostadilo y, a continuaci\u00f3n, masajear el pene manteni\u00e9ndolo en posici\u00f3n vertical para favorecer la absorci\u00f3n y evitar fugas.4<\/sup> Para obtener resultados \u00f3ptimos, los pacientes deben mantener relaciones sexuales entre 10 y 30 minutos despu\u00e9s de que el medicamento haga efecto.5<\/sup><\/p>\n

Los estudios de eficacia cl\u00ednica indican que el f\u00e1rmaco es eficaz en aproximadamente el 35 por ciento de los varones con disfunci\u00f3n er\u00e9ctil.6<\/sup> Los efectos adversos frecuentes incluyen dolor peneano (notificado por aproximadamente el 36 % de los usuarios), escozor uretral, sangrado uretral leve, mareos y, en casos excepcionales, priapismo (erecci\u00f3n dolorosa y prolongada que requiere atenci\u00f3n m\u00e9dica inmediata).7<\/sup> El tratamiento est\u00e1 contraindicado en pacientes con enfermedad de Peyronie, anemia de c\u00e9lulas falciformes, mieloma, leucemia o uretritis.8<\/sup><\/p>\n

Los profesionales sanitarios deben evaluar minuciosamente a los pacientes antes de prescribir supositorios intrauretrales, considerando sus antecedentes m\u00e9dicos, la medicaci\u00f3n concomitante y los posibles efectos adversos. La educaci\u00f3n del paciente sobre la t\u00e9cnica de administraci\u00f3n adecuada es crucial para el \u00e9xito y la seguridad del tratamiento.9<\/sup><\/p>\n","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":true,"gt-view-count":2},"yoast_head":"\nSupositorio intrauretral: MUSE y disfunci\u00f3n er\u00e9ctil<\/title>\n<meta name=\"description\" content=\"El supositorio intrauretral (MUSE) administra alprostadilo en la uretra para tratar la disfunci\u00f3n er\u00e9ctil si los f\u00e1rmacos orales fallan.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rigicon.com\/es\/glossary-term\/supositorio-intrauretral\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Supositorio intrauretral: MUSE y disfunci\u00f3n er\u00e9ctil\" \/>\n<meta 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