{"id":32225,"date":"2026-09-02T18:42:00","date_gmt":"2026-09-02T22:42:00","guid":{"rendered":"https:\/\/www.rigicon.com\/?post_type=glossary-term&p=32225"},"modified":"2026-09-03T06:12:00","modified_gmt":"2026-09-03T10:12:00","slug":"alprostadil","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/alprostadil\/","title":{"rendered":"Alprostadil"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[141],"glossary-product":[104,105],"class_list":["post-32225","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-erectile-dysfunction-treatments","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"<p>El alprostadil es un an\u00e1logo sint\u00e9tico de la prostaglandina E1 (PGE1) que se utiliza principalmente como tratamiento de segunda l\u00ednea para la disfunci\u00f3n er\u00e9ctil en hombres cuando la terapia oral ha fracasado.<span class=\"citation\">1<\/span> Act\u00faa uni\u00e9ndose como agonista a los receptores de prostaglandinas (p. ej., EP2), activando de este modo la adenilato ciclasa. Esto da lugar a una acumulaci\u00f3n de monofosfato de adenosina c\u00edclico 3&#8217;5&#8242; (AMPc), responsable de los efectos farmacol\u00f3gicos del medicamento, entre los que se incluyen la relajaci\u00f3n del m\u00fasculo liso que conduce a la vasodilataci\u00f3n (aumentando el flujo sangu\u00edneo perif\u00e9rico e intracavernoso), la broncodilataci\u00f3n y la inhibici\u00f3n de la agregaci\u00f3n plaquetaria.<span class=\"citation\">1<\/span><\/p>\n","gt-synonyms":"Prostaglandina E1, PGE1, PGE-1, l-prostaglandina E1, Alprostadilo, Alprostadilum, Befar, Caverject, Caverject Impulse, Edex, Muse, Vitaros, Femprox, Topiglan, Alprox-TD, Liprostin, Prostandin, Prostin VR Pediatric, Prostavasin, Lipoprost, Promostan, Prostivas, l-PGE1, PGE1alpha, \u00e1cido (11alpha,13E,15S)-11,15-dihidroxi-9-oxoprost-13-en-1-oico, (-)-Prostaglandina E1","gt-citation":"[1] Jain A, Leslie SW, Iqbal O. Alprostadil. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542217\/\n\n[2] Anaissie J, Hellstrom WJ. Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review. Res Rep Urol. 2016;8:123-131. Published 2016 Aug 3. doi:10.2147\/RRU.S68560\n\n[3] Linet OI, Ogrinc FG. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The Alprostadil Study Group. N Engl J Med. 1996;334(14):873-877. doi:10.1056\/NEJM199604043341401\n\n[4] Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med. 1997;336(1):1-7. doi:10.1056\/NEJM199701023360101\n\n[5] Cai T, Palumbo F, Liguori G, et al. The intra-meatal application of alprostadil cream (Vitaros\u00ae) improves drug efficacy and patient's satisfaction: results from a randomized, two-administration route, cross-over clinical trial. Int J Impot Res. 2019;31(2):119-125. doi:10.1038\/s41443-018-0087-6","gt-clinical-context":"<p>El alprostadil est\u00e1 aprobado por la FDA como tratamiento de segunda l\u00ednea para la disfunci\u00f3n er\u00e9ctil cuando las terapias orales de primera l\u00ednea, como los inhibidores de la fosfodiesterasa tipo 5 (PDE5) (p. ej., sildenafilo), resultan ineficaces.<span class=\"citation\">1<\/span> Puede administrarse mediante inyecci\u00f3n intracavernosa, supositorio intrauretral o crema t\u00f3pica.<span class=\"citation\">2<\/span> El f\u00e1rmaco act\u00faa relajando el tejido muscular liso de los cuerpos cavernosos, dilatando las arterias cavernosas, aumentando el flujo sangu\u00edneo y provocando una erecci\u00f3n.<span class=\"citation\">1<\/span><\/p>\n<p>Para la disfunci\u00f3n er\u00e9ctil, el alprostadil est\u00e1 disponible en varias formulaciones:<\/p>\n<ul>\n<li><strong>Inyecci\u00f3n intracavernosa<\/strong>: El alprostadil es el \u00fanico f\u00e1rmaco aprobado por la FDA para inyecciones intracavernosas en el tratamiento de la disfunci\u00f3n er\u00e9ctil.<span class=\"citation\">1<\/span> Los ensayos cl\u00ednicos han demostrado que el alprostadil intracavernoso es eficaz en el 70-80 % de los pacientes con disfunci\u00f3n er\u00e9ctil.<span class=\"citation\">3<\/span><\/li>\n<li><strong>Supositorio intrauretral<\/strong> (MUSE &#8211; Medicated Urethral System for Erection): Esta alternativa menos invasiva ha demostrado una eficacia de aproximadamente el 43 % en los pacientes.<span class=\"citation\">4<\/span><\/li>\n<li><strong>Crema t\u00f3pica<\/strong> (Vitaros, Femprox): La crema t\u00f3pica de alprostadil ha demostrado ser eficaz y bien tolerada, aumentando la puntuaci\u00f3n de la funci\u00f3n er\u00e9ctil del \u00cdndice Internacional de Funci\u00f3n Er\u00e9ctil hasta en 13 puntos con respecto al valor basal.<span class=\"citation\">2<\/span> Ofrece una opci\u00f3n menos invasiva con menos efectos secundarios sist\u00e9micos.<\/li>\n<\/ul>\n<p>El alprostadil tambi\u00e9n se puede combinar con otros medicamentos, como en la formulaci\u00f3n conocida como &#8220;Trimix&#8221;, que incluye papaverina, fentolamina y alprostadil.<span class=\"citation\">1<\/span> Esta combinaci\u00f3n es especialmente eficaz cuando se administra mediante inyecci\u00f3n intracavernosa.<\/p>\n<p>M\u00e1s all\u00e1 de la disfunci\u00f3n er\u00e9ctil, el alprostadil tambi\u00e9n est\u00e1 aprobado por la FDA para mantener temporalmente la permeabilidad del conducto arterioso en neonatos con cardiopat\u00edas cong\u00e9nitas dependientes del conducto hasta la intervenci\u00f3n quir\u00fargica.<span class=\"citation\">1<\/span> Otras aplicaciones cl\u00ednicas incluyen el manejo de alteraciones isqu\u00e9micas en pacientes con fen\u00f3meno de Raynaud, el tratamiento de la neuropat\u00eda perif\u00e9rica diab\u00e9tica, la prevenci\u00f3n de la nefropat\u00eda inducida por contraste y trasplante hep\u00e1tico para mejorar el flujo vascular hep\u00e1tico y reducir la lesi\u00f3n por isquemia-reperfusi\u00f3n.<span class=\"citation\">1<\/span><\/p>\n<p>Los criterios de selecci\u00f3n de pacientes para el tratamiento con alprostadil suelen incluir a personas que:<\/p>\n<ul>\n<li>Han presentado fracaso terap\u00e9utico o no toleran los inhibidores orales de la PDE5<span class=\"citation\">2<\/span><\/li>\n<li>Presentan contraindicaciones para los inhibidores de la PDE5 (p. ej., uso de nitratos)<span class=\"citation\">1<\/span><\/li>\n<li>Padecen disfunci\u00f3n er\u00e9ctil de diversas etiolog\u00edas (vasculog\u00e9nica, psic\u00f3gena o mixta)<span class=\"citation\">2<\/span><\/li>\n<li>Requieren una prueba diagn\u00f3stica para la disfunci\u00f3n er\u00e9ctil<span class=\"citation\">3<\/span><\/li>\n<\/ul>\n","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":true,"gt-view-count":4},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) 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