{"id":12191,"date":"2025-08-14T10:18:06","date_gmt":"2025-08-14T14:18:06","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/coaptite\/"},"modified":"2026-10-06T18:04:24","modified_gmt":"2026-10-06T22:04:24","slug":"coaptite","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/coaptite\/","title":{"rendered":"Coaptite"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[123],"glossary-product":[],"class_list":["post-12191","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urinary-incontinence-treatments"],"acf":{"gt-definition":"<p>Coaptite<sup>\u00ae<\/sup> es un implante inyectable, est\u00e9ril y apir\u00f3geno, compuesto por part\u00edculas esf\u00e9ricas de hidroxiapatita c\u00e1lcica (CaHA) (de 75-125 micras de di\u00e1metro) suspendidas en un gel portador de base acuosa.<sup>1<\/sup> El gel portador est\u00e1 compuesto por carboximetilcelulosa s\u00f3dica, agua est\u00e9ril para inyecci\u00f3n y glicerina.<sup>1<\/sup> Este material biocompatible se inyecta por v\u00eda submucosa en el cuello vesical y\/o en la uretra media, lo que aumenta el volumen tisular y produce un aumento de los tejidos blandos.<sup>2<\/sup><\/p>\n    \n    <p>La finalidad principal de Coaptite es tratar la incontinencia urinaria de esfuerzo (IUE) debida a deficiencia esfinteriana intr\u00ednseca (DEI) en mujeres adultas.<sup>1,2<\/sup> Una vez inyectado, el gel portador mantiene en suspensi\u00f3n las part\u00edculas de CaHA y permite su administraci\u00f3n a trav\u00e9s de agujas de inyecci\u00f3n, tras lo cual se disipa in vivo.<sup>3<\/sup> Las part\u00edculas de CaHA permanecen en los puntos de inyecci\u00f3n y aportan el volumen tisular necesario para producir la coaptaci\u00f3n de la uretra, lo que aumenta la resistencia uretral a la p\u00e9rdida de orina.<sup>3<\/sup> Este mecanismo crea un andamiaje para el posible crecimiento tisular hacia su interior, lo que facilita el desarrollo de tejido nuevo en la zona inyectada.<sup>4<\/sup><\/p>\n    \n    <p>Coaptite ofrece una opci\u00f3n de tratamiento duradera, aunque no permanente, y los estudios cl\u00ednicos demuestran que su eficacia se mantiene durante 3 a\u00f1os.<sup>4<\/sup> Como agente de relleno uretral, ofrece una alternativa menos invasiva a las intervenciones quir\u00fargicas para las candidatas adecuadas con incontinencia urinaria de esfuerzo.<sup>2<\/sup><\/p>","gt-synonyms":"Agente de carga uretral de hidroxiapatita de calcio, Agente de carga uretral CaHA, Implante inyectable Coaptite\u00ae, Material de aumento de tejido blando de hidroxiapatita de calcio","gt-citation":"[1] U.S. Food and Drug Administration. Summary of Safety and Effectiveness Data: Coaptite. P040047. November 10, 2005. DOI: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf4\/p040047b.pdf\n\n[2] Mayer RD, Dmochowski RR, Appell RA, Sand PK, Klimberg IW, Jacoby K, Graham CW, Snyder JA, Nitti VW, Winters JC. Multicenter prospective randomized 52-week trial of calcium hydroxylapatite versus bovine dermal collagen for treatment of stress urinary incontinence. Urology. 2007 May;69(5):876-80. DOI: 10.1016\/j.urology.2007.01.050\n\n[3] Coaptite Injectable Implant Instructions for Use. Merz Pharmaceuticals, LLC. DOI: https:\/\/www.coaptite.com\/pdfs\/coaptite_IFU.pdf\n\n[4] Merz Pharmaceuticals. Coaptite Urethral Bulking Injection. 2025. https:\/\/www.coaptite.com\/","gt-clinical-context":"<p>Coaptite se utiliza cl\u00ednicamente para el tratamiento de la incontinencia urinaria de esfuerzo (IUE) debida a deficiencia esfinteriana intr\u00ednseca (DEI) en mujeres adultas.<sup>1<\/sup> Esta afecci\u00f3n se caracteriza por la p\u00e9rdida involuntaria de orina durante las actividades f\u00edsicas que aumentan la presi\u00f3n abdominal, como toser, estornudar o hacer ejercicio, debido al debilitamiento de la funci\u00f3n del esf\u00ednter uretral.<\/p>\n    \n    <p>Los criterios de selecci\u00f3n de pacientes suelen incluir a mujeres adultas con incontinencia urinaria de esfuerzo documentada debida a DEI sin hipermovilidad uretral asociada.<sup>2<\/sup> Las candidatas deben haber presentado fracaso de los tratamientos conservadores y haber mostrado su disposici\u00f3n a someterse a procedimientos m\u00ednimamente invasivos. El procedimiento est\u00e1 contraindicado en pacientes con antecedentes importantes de infecciones urinarias no resueltas, con cistitis o uretritis actual o aguda y en aquellas con una mucosa uretral fr\u00e1gil.<sup>1<\/sup><\/p>\n    \n    <p>El procedimiento quir\u00fargico consiste en inyectar Coaptite por v\u00eda submucosa en el cuello vesical y\/o en la uretra media mediante una aguja peque\u00f1a de calibre 21 dise\u00f1ada para la comodidad de la paciente.<sup>3<\/sup> Las marcas circunferenciales de la aguja ayudan a guiar la colocaci\u00f3n, y el procedimiento puede realizarse con anestesia local de forma ambulatoria. Pueden utilizarse varios puntos de inyecci\u00f3n para lograr una coaptaci\u00f3n \u00f3ptima de la uretra.<\/p>\n    \n    <p>Los estudios cl\u00ednicos han demostrado que Coaptite mantiene tasas de \u00e9xito elevadas durante 3 a\u00f1os<sup>4<\/sup> con una eficacia comparable a la del col\u00e1geno bovino tradicional.<sup>2<\/sup> En un ensayo multic\u00e9ntrico, prospectivo y aleatorizado de 52 semanas que compar\u00f3 Coaptite con col\u00e1geno d\u00e9rmico bovino, el 63,4% de las pacientes tratadas con Coaptite mostraron una mejor\u00eda de un grado de Stamey o m\u00e1s a los 12 meses.<sup>2<\/sup> Adem\u00e1s, un mayor n\u00famero de pacientes tratadas con Coaptite necesitaron una sola inyecci\u00f3n (38,0%) en comparaci\u00f3n con las tratadas con col\u00e1geno (26,1%), y el volumen total medio de material inyectado fue menor con Coaptite que con col\u00e1geno (4,0 ml frente a 6,6 ml).<sup>2<\/sup><\/p>\n    \n    <p>Los resultados esperados incluyen una reducci\u00f3n de la p\u00e9rdida de orina, una mejora de la calidad de vida y una mejor\u00eda potencialmente duradera.<sup>2<\/sup> El procedimiento ofrece una opci\u00f3n menos invasiva que las intervenciones quir\u00fargicas, con un tiempo de recuperaci\u00f3n m\u00ednimo y menos complicaciones.<sup>4<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":106},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Coaptite: Calcium Hydroxylapatite Urethral Bulking Agent...<\/title>\n<meta name=\"description\" content=\"Coaptite es un agente de volumen uretral de hidroxiapatita c\u00e1lcica indicado en el tratamiento de la incontinencia urinaria de esfuerzo en mujeres.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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