{"id":12122,"date":"2025-07-31T10:48:49","date_gmt":"2025-07-31T14:48:49","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/leukocytospermia\/"},"modified":"2026-10-06T18:04:24","modified_gmt":"2026-10-06T22:04:24","slug":"leucocitospermia","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/leucocitospermia\/","title":{"rendered":"Leucocitospermia"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[126],"glossary-product":[],"class_list":["post-12122","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-conditions"],"acf":{"gt-definition":"<p>La leucocitospermia se define como la presencia de una concentraci\u00f3n anormalmente elevada de gl\u00f3bulos blancos (leucocitos) en el semen, concretamente superior a 1 \u00d7 10<sup>6<\/sup> leucocitos por mililitro de eyaculado, seg\u00fan los criterios de la Organizaci\u00f3n Mundial de la Salud.<sup>1<\/sup> Este trastorno representa un estado inflamatorio del tracto reproductor masculino que puede indicar una infecci\u00f3n, una inflamaci\u00f3n u otros procesos patol\u00f3gicos subyacentes.<sup>2<\/sup> La presencia excesiva de leucocitos puede generar especies reactivas de ox\u00edgeno (ERO), que pueden da\u00f1ar las membranas de los espermatozoides, alterar su funci\u00f3n y, potencialmente, comprometer los resultados de fertilidad.<sup>3<\/sup> La leucocitospermia se encuentra tanto en hombres f\u00e9rtiles como en hombres inf\u00e9rtiles, aunque parece ser m\u00e1s frecuente en este \u00faltimo grupo, ya que afecta aproximadamente al 30% de los varones inf\u00e9rtiles.<sup>4<\/sup><\/p>","gt-synonyms":"Leucospermia, Piospermia","gt-citation":"[1] World Health Organization. (2010). WHO laboratory manual for the examination and processing of human semen, 5th ed. Geneva: World Health Organization. https:\/\/iris.who.int\/handle\/10665\/44261\n\n[2] Khodamoradi K, Kuchakulla M, Narasimman M, et al. (2020). Laboratory and clinical management of leukocytospermia and hematospermia: a review. Therapeutic Advances in Reproductive Health, 14:2633494120922511. DOI: 10.1177\/2633494120922511\n\n[3] Sandoval JS, Raburn D, Muasher S. (2013). Leukocytospermia: Overview of diagnosis, implications, and management of a controversial finding. Middle East Fertility Society Journal, 18(3):129-134. DOI: 10.1016\/j.mefs.2013.02.004\n\n[4] Jung JH, Kim MH, Kim J, et al. (2016). Treatment of Leukocytospermia in Male Infertility: A Systematic Review. World Journal of Men's Health, 34(3):165-172. DOI: 10.5534\/wjmh.2016.34.3.165\n\n[5] Ricci G, Perticarari S, Fragonas E, et al. (2009). Leukocytospermia and sperm preparation - a flow cytometric study. Reproductive Biology and Endocrinology, 7:128. DOI: 10.1186\/1477-7827-7-128","gt-clinical-context":"<p>La leucocitospermia tiene relevancia cl\u00ednica en la evaluaci\u00f3n y el tratamiento de la infertilidad masculina.<sup>1<\/sup> El trastorno se diagnostica mediante varios m\u00e9todos: la tinci\u00f3n inmunohistoqu\u00edmica con anticuerpos monoclonales se considera el m\u00e9todo de referencia, aunque en la pr\u00e1ctica cl\u00ednica se utiliza con m\u00e1s frecuencia la tinci\u00f3n con peroxidasa por su practicidad.<sup>2<\/sup> Otros enfoques diagn\u00f3sticos incluyen la prueba de Endtz, la citometr\u00eda de flujo y la determinaci\u00f3n de la elastasa granuloc\u00edtica seminal.<sup>3<\/sup><\/p>\n    \n    <p>La etiolog\u00eda de la leucocitospermia es multifactorial e incluye infecciones del tracto genital (bacterianas o v\u00edricas), inflamaci\u00f3n sin infecci\u00f3n, varicocele, tabaquismo y traumatismos como la lesi\u00f3n medular.<sup>4<\/sup> Curiosamente, en aproximadamente el 80% de los varones inf\u00e9rtiles con leucocitospermia no puede detectarse ninguna infecci\u00f3n microbiana a pesar de la respuesta inflamatoria.<sup>2<\/sup><\/p>\n    \n    <p>Desde el punto de vista cl\u00ednico, la leucocitospermia se ha asociado con alteraciones de la espermatog\u00e9nesis, reducci\u00f3n de la motilidad esperm\u00e1tica, defectos en la funci\u00f3n del flagelo del espermatozoide y mayores tasas de teratoastenozoospermia y necrozoospermia.<sup>2<\/sup> El trastorno puede dificultar la capacidad fecundante de los espermatozoides al interferir en la reacci\u00f3n acros\u00f3mica y en los procesos de fusi\u00f3n entre el espermatozoide y el \u00f3vulo.<sup>3<\/sup> El principal mecanismo de da\u00f1o parece ser el de las especies reactivas de ox\u00edgeno generadas por los leucocitos, que pueden provocar la peroxidaci\u00f3n lip\u00eddica de las membranas de los espermatozoides, ricas en \u00e1cidos grasos poliinsaturados.<sup>3<\/sup><\/p>\n    \n    <p>Los enfoques terap\u00e9uticos var\u00edan seg\u00fan la etiolog\u00eda sospechada e incluyen antibi\u00f3ticos (tetraciclinas, quinolonas, macr\u00f3lidos) en caso de sospecha de infecci\u00f3n, antiinflamatorios, antioxidantes y modificaciones del estilo de vida como el abandono del tabaco.<sup>5<\/sup> En los casos en que la leucocitospermia afecta a los resultados de fertilidad, pueden considerarse las t\u00e9cnicas de reproducci\u00f3n asistida, prestando especial atenci\u00f3n a las t\u00e9cnicas de preparaci\u00f3n del semen que permiten separar los espermatozoides de los gl\u00f3bulos blancos.<sup>4<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":148},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Leucocitospermia<\/title>\n<meta name=\"description\" content=\"La leucocitospermia es la presencia elevada de 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