{"id":12029,"date":"2025-06-11T07:53:50","date_gmt":"2025-06-11T11:53:50","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/androgen-deprivation-therapy-adt\/"},"modified":"2025-06-11T07:53:50","modified_gmt":"2025-06-11T11:53:50","slug":"terapia-de-deprivacion-androgenica-tda","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/terapia-de-deprivacion-androgenica-tda\/","title":{"rendered":"Terapia de Deprivaci\u00f3n Androg\u00e9nica (TDA)"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[137],"glossary-product":[108,107,104,105],"class_list":["post-12029","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-hormone-therapy","glossary-product-conticlassic-aus","glossary-product-contireflex-enhanced-aus","glossary-product-infla10-pulse-ipp-series","glossary-product-rigi10-malleable-penile-prosthesis"],"acf":{"gt-definition":"La terapia de privaci\u00f3n de andr\u00f3genos (ADT) es un tratamiento fundamental para el c\u00e1ncer de pr\u00f3stata, especialmente en etapas avanzadas. Funciona reduciendo los niveles de andr\u00f3genos (hormonas masculinas como la testosterona) en el cuerpo o impidiendo que estas hormonas lleguen a las c\u00e9lulas cancerosas.\u00b9 Los andr\u00f3genos estimulan el crecimiento de las c\u00e9lulas cancerosas de la pr\u00f3stata; por lo tanto, reducir sus niveles o bloquear su acci\u00f3n puede retardar el crecimiento tumoral, reducir su tama\u00f1o y aliviar los s\u00edntomas.\u00b9 La ADT se puede lograr mediante medios quir\u00fargicos (orquiectom\u00eda, extirpaci\u00f3n de test\u00edculos) o, m\u00e1s com\u00fanmente, mediante medicamentos como agonistas de la LHRH (hormona liberadora de hormona luteinizante), antagonistas de la LHRH o antiandr\u00f3genos.\u00b9 Los agonistas y antagonistas de la LHRH act\u00faan alterando la v\u00eda de se\u00f1alizaci\u00f3n que conduce a la producci\u00f3n de testosterona en los test\u00edculos, logrando efectivamente la castraci\u00f3n m\u00e9dica.\u00b9 Los antiandr\u00f3genos, por otro lado, bloquean los receptores de andr\u00f3genos en las c\u00e9lulas cancerosas, evitando que la testosterona se una y ejerza sus efectos promotores del crecimiento.\u00b9 Algunos agentes m\u00e1s nuevos, conocidos como inhibidores de la s\u00edntesis de andr\u00f3genos, pueden bloquear la producci\u00f3n de andr\u00f3genos en todo el cuerpo, incluso desde las gl\u00e1ndulas suprarrenales y las c\u00e9lulas cancerosas. ellos mismos.\u00b9","gt-synonyms":"Terapia hormonal para el c\u00e1ncer de pr\u00f3stata, Terapia de supresi\u00f3n androg\u00e9nica, castraci\u00f3n m\u00e9dica, Castraci\u00f3n quir\u00fargica (si es orquiectom\u00eda), Bloqueo androg\u00e9nico combinado (CAB) (cuando se usa con antiandr\u00f3genos)","gt-citation":"[1] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. National Institutes of Health. Actualizado October 4, 2024. Accessed May 14, 2025. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\n\n[2] Singh M, Agarwal V, Pancham P, et al. A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer\u2019s Disease Risk in Older Men with Prostate Cancer. Degener Neurol Neuromuscul Dis. 2024;14:33-46. Published 2024 May 17. doi:10.2147\/DNND.S445130","gt-clinical-context":"La ADT se emplea en diversos escenarios cl\u00ednicos para el tratamiento del c\u00e1ncer de pr\u00f3stata.\u00b9 Es un est\u00e1ndar de atenci\u00f3n para el c\u00e1ncer de pr\u00f3stata metast\u00e1sico, donde la enfermedad se ha diseminado a otras partes del cuerpo.\u00b9 Tambi\u00e9n se usa para el c\u00e1ncer de pr\u00f3stata localmente avanzado, a menudo junto con radioterapia, para mejorar la eficacia del tratamiento.\u00b9 En hombres con c\u00e1ncer de pr\u00f3stata recurrente despu\u00e9s de tratamientos iniciales como cirug\u00eda o radiaci\u00f3n, la ADT se puede usar para controlar la enfermedad, especialmente si la recurrencia es sintom\u00e1tica o si hay hay evidencia de niveles crecientes de PSA (ant\u00edgeno prost\u00e1tico espec\u00edfico) que indican progresi\u00f3n de la enfermedad.\u00b9 La selecci\u00f3n de pacientes para ADT considera factores como el estadio y el grado del c\u00e1ncer, la salud general del paciente, los posibles efectos secundarios y las preferencias del paciente.\u00b9 Los resultados esperados incluyen una reducci\u00f3n en los niveles de PSA, reducci\u00f3n de tumores, alivio de los s\u00edntomas relacionados con el c\u00e1ncer (como dolor de huesos) y, en muchos casos, una extensi\u00f3n de la supervivencia.\u00b9 Sin embargo, La ADT se asocia con una variedad de efectos secundarios, que incluyen sofocos, p\u00e9rdida de la libido, disfunci\u00f3n er\u00e9ctil, fatiga y posibles efectos a largo plazo, como p\u00e9rdida de densidad \u00f3sea y cambios metab\u00f3licos, que deben controlarse.\u00b9","gt-related-evidence":null,"gt-featured":false,"gt-ai-referenced":false,"gt-view-count":104},"yoast_head":"\nTerapia de Deprivaci\u00f3n Androg\u00e9nica (TDA) for Prostate Cancer<\/title>\n<meta name=\"description\" content=\"Obtenga m\u00e1s informaci\u00f3n sobre la terapia de privaci\u00f3n de andr\u00f3genos (ADT), un tratamiento hormonal clave para el 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