{"id":11995,"date":"2025-07-22T08:26:38","date_gmt":"2025-07-22T12:26:38","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/antiandrogen\/"},"modified":"2025-07-22T08:26:38","modified_gmt":"2025-07-22T12:26:38","slug":"antiandrogeno","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/es\/glossary-term\/antiandrogeno\/","title":{"rendered":"Antiandr\u00f3geno"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[114],"glossary-product":[],"class_list":["post-11995","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-agents"],"acf":{"gt-definition":"<p>Los antiandr\u00f3genos son medicamentos que act\u00faan uni\u00e9ndose a los receptores de andr\u00f3genos intracelulares, previniendo los efectos de los andr\u00f3genos end\u00f3genos en los tejidos diana como los test\u00edculos, los fol\u00edculos pilosos, el hipot\u00e1lamo, la pituitaria, los ovarios y la pr\u00f3stata.<sup>1<\/sup> Estos medicamentos antagonizan la acci\u00f3n de los andr\u00f3genos al prohibir la uni\u00f3n de los andr\u00f3genos con el receptor de andr\u00f3genos. (AR), bloqueando as\u00ed la se\u00f1al de andr\u00f3genos mediante la inhibici\u00f3n de la translocaci\u00f3n nuclear.<sup>2<\/sup> Los antiandr\u00f3genos se clasifican en esteroides (como el acetato de ciproterona) y no esteroides (incluyendo flutamida, nilutamida, bicalutamida, enzalutamida, apalutamida y darolutamida).<sup>3<\/sup> Los antiandr\u00f3genos de nueva generaci\u00f3n (enzalutamida, apalutamida, darolutamida) tienen una mayor afinidad por el AR, lo que optimiza el efecto de bloqueo de los andr\u00f3genos.<sup>4<\/sup> Los antiandr\u00f3genos se usan principalmente en el tratamiento del c\u00e1ncer de pr\u00f3stata, pero tambi\u00e9n se emplean en otras afecciones donde es beneficioso reducir los efectos de los andr\u00f3genos.<sup>5<\/sup><\/p>","gt-synonyms":"Antagonistas de los receptores de andr\u00f3genos, bloqueadores de los receptores de andr\u00f3genos, bloqueadores de testosterona, inhibidores de AR, antagonistas de andr\u00f3genos","gt-citation":"[1] Lanz C, Bennamoun M, Macek P, Cathelineau X, Sanchez-Salas R. The importance of antiandrogen in prostate cancer treatment. Ann Transl Med. 2019;7(Suppl 8):S362. DOI: 10.21037\/atm.2019.09.53\n\n[2] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. Actualizado October 4, 2024. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\n\n[3] LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2014. Antiandrogens. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548491\/\n\n[4] Gao W, Mahto M. Commercial Antiandrogens. In: Understanding Cancer, 2016. https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/antiandrogen\n\n[5] American Cancer Society. Hormone Therapy for Prostate Cancer. Actualizado November 22, 2023. https:\/\/www.cancer.org\/cancer\/types\/prostate-cancer\/treating\/hormone-therapy.html","gt-clinical-context":"<p>Los antiandr\u00f3genos se utilizan principalmente en el tratamiento del c\u00e1ncer de pr\u00f3stata, donde desempe\u00f1an un papel importante tanto en la enfermedad sensible a la castraci\u00f3n como en la resistente a la castraci\u00f3n.<sup>1<\/sup> Desde el descubrimiento de los receptores de andr\u00f3genos a finales de la d\u00e9cada de 1960, se ha entendido que su activaci\u00f3n induce la translocaci\u00f3n del citoplasma al n\u00facleo, lo que conduce a la expresi\u00f3n de proliferaci\u00f3n. genes.<sup>2<\/sup><\/p>\n    \n    <p>En el tratamiento del c\u00e1ncer de pr\u00f3stata, los antiandr\u00f3genos a menudo se usan en combinaci\u00f3n con la terapia de privaci\u00f3n de andr\u00f3genos (ADT) para lograr un bloqueo androg\u00e9nico completo.<sup>3<\/sup> Esta combinaci\u00f3n reduce los niveles de andr\u00f3genos y evita que los andr\u00f3genos restantes se unan a los receptores de andr\u00f3genos. Los antiandr\u00f3genos de primera generaci\u00f3n (flutamida, nilutamida, bicalutamida) han demostrado beneficios cl\u00ednicos al mejorar la supervivencia general entre 3 y 8 meses y extender la supervivencia libre de progresi\u00f3n en el c\u00e1ncer de pr\u00f3stata metast\u00e1sico sensible a la castraci\u00f3n.<sup>4<\/sup><\/p>\n    \n    <p>Los antiandr\u00f3genos de nueva generaci\u00f3n (enzalutamida, apalutamida, darolutamida) han demostrado mayor eficacia. Por ejemplo, la enzalutamida ha demostrado una mejora en la supervivencia general en el c\u00e1ncer de pr\u00f3stata metast\u00e1sico resistente a la castraci\u00f3n, tanto antes como despu\u00e9s de la quimioterapia (ensayos PREVAIL y AFFIRM), y una mejora en la supervivencia libre de met\u00e1stasis en el c\u00e1ncer de pr\u00f3stata no metast\u00e1sico resistente a la castraci\u00f3n (ensayo PROSPER).<sup>5<\/sup> De manera similar, la apalutamida ha demostrado una mejora en la supervivencia libre de met\u00e1stasis en hombres con c\u00e1ncer de pr\u00f3stata no metast\u00e1sico resistente a la castraci\u00f3n que tienen un alto riesgo de desarrollar met\u00e1stasis (ensayo SPARTAN).<sup>6<\/sup><\/p>\n    \n    <p>La selecci\u00f3n de pacientes para la terapia antiandr\u00f3gena depende del estadio y las caracter\u00edsticas del c\u00e1ncer de pr\u00f3stata. Seg\u00fan las directrices internacionales (EUA, NCCN, AUA), los antiandr\u00f3genos se recomiendan para pacientes con c\u00e1ncer de pr\u00f3stata no metast\u00e1sico resistente a la castraci\u00f3n que tienen un alto riesgo de met\u00e1stasis, as\u00ed como para diversas etapas de la enfermedad metast\u00e1sica.<sup>7<\/sup><\/p>\n    \n    <p>M\u00e1s all\u00e1 del c\u00e1ncer de pr\u00f3stata, los antiandr\u00f3genos tambi\u00e9n se usan en el tratamiento de otras afecciones como el hirsutismo, el acn\u00e9 y las parafilias, aunque estas aplicaciones var\u00edan seg\u00fan el agente espec\u00edfico y, a veces, no est\u00e1n indicadas en la etiqueta.<sup>8<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":90},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Antiandr\u00f3geno: Mechanism and Clinical 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