{"id":11868,"date":"2025-07-22T08:26:38","date_gmt":"2025-07-22T12:26:38","guid":{"rendered":"https:\/\/www.rigicon.com\/glossary-term\/antiandrogen\/"},"modified":"2025-07-22T08:26:38","modified_gmt":"2025-07-22T12:26:38","slug":"antiandrogen","status":"publish","type":"glossary-term","link":"https:\/\/www.rigicon.com\/de\/glossary-term\/antiandrogen\/","title":{"rendered":"Antiandrogen"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","glossary-category":[114],"glossary-product":[],"class_list":["post-11868","glossary-term","type-glossary-term","status-publish","hentry","glossary-category-urological-agents"],"acf":{"gt-definition":"<p>Antiandrogene sind Medikamente, die durch Bindung an intrazellul\u00e4re Androgenrezeptoren wirken und so die Wirkung endogener Androgene auf Zielgewebe wie Hoden, Haarfollikel, Hypothalamus, Hypophyse, Eierst\u00f6cke und Prostatadr\u00fcse verhindern Kerntranslokation.<sup>2<\/sup> Antiandrogene werden in steroidale (wie Cyproteronacetat) und nichtsteroidale (einschlie\u00dflich Flutamid, Nilutamid, Bicalutamid, Enzalutamid, Apalutamid und Darolutamid) eingeteilt.<sup>3<\/sup> Die Antiandrogene der neueren Generation (Enzalutamid, Apalutamid, Darolutamid) haben eine h\u00f6here Affinit\u00e4t zum AR, was die Wirkung optimiert Androgen-Blockade-Effekt.<sup>4<\/sup> Antiandrogene werden haupts\u00e4chlich zur Behandlung von Prostatakrebs eingesetzt, werden aber auch bei anderen Erkrankungen eingesetzt, bei denen eine Verringerung der Androgenwirkung von Vorteil ist.<sup>5<\/sup><\/p>","gt-synonyms":"Androgenrezeptorantagonisten, Androgenrezeptorblocker, Testosteronblocker, AR-Inhibitoren, Androgenantagonisten","gt-citation":"[1] Lanz C, Bennamoun M, Macek P, Cathelineau X, Sanchez-Salas R. The importance of antiandrogen in prostate cancer treatment. Ann Transl Med. 2019;7(Suppl 8):S362. DOI: 10.21037\/atm.2019.09.53\n\n[2] National Cancer Institute. Hormone Therapy for Prostate Cancer Fact Sheet. Aktualisiert October 4, 2024. https:\/\/www.cancer.gov\/types\/prostate\/prostate-hormone-therapy-fact-sheet\n\n[3] LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2014. Antiandrogens. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548491\/\n\n[4] Gao W, Mahto M. Commercial Antiandrogens. In: Understanding Cancer, 2016. https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/antiandrogen\n\n[5] American Cancer Society. Hormone Therapy for Prostate Cancer. Aktualisiert November 22, 2023. https:\/\/www.cancer.org\/cancer\/types\/prostate-cancer\/treating\/hormone-therapy.html","gt-clinical-context":"<p>Antiandrogene werden haupts\u00e4chlich bei der Behandlung von Prostatakrebs eingesetzt, wo sie sowohl bei kastrationsempfindlichen als auch bei kastrationsresistenten Erkrankungen eine wichtige Rolle spielen.<sup>1<\/sup> Seit der Entdeckung der Androgenrezeptoren in den sp\u00e4ten 1960er Jahren wei\u00df man, dass ihre Aktivierung die Translokation vom Zytoplasma in den Zellkern induziert, was zur Expression von Proliferationsgenen f\u00fchrt.<sup>2<\/sup><\/p>\n \n <p>Bei der Behandlung von Prostatakrebs werden Antiandrogene h\u00e4ufig in Kombination mit einer Androgenentzugstherapie (ADT) eingesetzt, um eine vollst\u00e4ndige Androgenblockade zu erreichen.<sup>3<\/sup> Diese Kombination senkt sowohl den Androgenspiegel als auch verhindert, dass verbleibendes Androgen an Androgenrezeptoren bindet. Die Antiandrogene der ersten Generation (Flutamid, Nilutamid, Bicalutamid) haben einen klinischen Nutzen gezeigt, indem sie das Gesamt\u00fcberleben zwischen 3 und 8 Monaten verbessern und das progressionsfreie \u00dcberleben bei metastasiertem kastrationsempfindlichem Prostatakrebs verl\u00e4ngern.<sup>4<\/sup><\/p>\n \n <p>Die Antiandrogene der neueren Generation (Enzalutamid, Apalutamid, Darolutamid) haben eine gr\u00f6\u00dfere Wirksamkeit gezeigt. Enzalutamid hat beispielsweise eine Verbesserung des Gesamt\u00fcberlebens bei metastasiertem kastrationsresistentem Prostatakrebs sowohl vor als auch nach der Chemotherapie gezeigt (PREVAIL- und AFFIRM-Studien) und eine Verbesserung des metastasenfreien \u00dcberlebens bei nicht metastasiertem kastrationsresistentem Prostatakrebs (PROSPER-Studie).<sup>5<\/sup> Ebenso hat Apalutamid ein verbessertes metastasenfreies \u00dcberleben bei M\u00e4nnern mit nicht metastasiertem kastrationsresistentem Prostatakrebs gezeigt, bei denen ein hohes Risiko besteht, daran zu erkranken Metastasen (SPARTAN-Studie).<sup>6<\/sup><\/p>\n \n <p>Die Patientenauswahl f\u00fcr eine Antiandrogentherapie h\u00e4ngt vom Stadium und den Merkmalen des Prostatakrebses ab. Nach internationalen Leitlinien (EAU, NCCN, AUA) werden Antiandrogene f\u00fcr Patienten mit nicht metastasiertem kastrationsresistentem Prostatakrebs, bei denen ein hohes Metastasierungsrisiko besteht, sowie f\u00fcr verschiedene Stadien der Metastasierung empfohlen.<sup>7<\/sup><\/p>\n \n <p>\u00dcber Prostatakrebs hinaus werden Antiandrogene auch zur Behandlung anderer Erkrankungen wie Hirsutismus, Akne und Paraphilien eingesetzt, wobei diese Anwendungen je nach Wirkstoff variieren und manchmal nicht zugelassen sind.<sup>8<\/sup><\/p>","gt-related-evidence":null,"gt-featured":true,"gt-ai-referenced":false,"gt-view-count":42},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Antiandrogen: Mechanism and Clinical Applications<\/title>\n<meta name=\"description\" content=\"Antiandrogene blockieren die Wirkung m\u00e4nnlicher Hormone durch Bindung an 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